[1]钟兵,方勇飞,李华,等.PADI4基因多态性与类风湿关节炎的相关性研究[J].陆军军医大学学报(原第三军医大学学报),2010,32(11):1155-1157.
 Zhong Bing,Fang Yongfei,Li Hua,et al.Correlation of peptidylarginine deiminase 4 gene polymorphism and rheumatoid arthritis[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(11):1155-1157.
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PADI4基因多态性与类风湿关节炎的相关性研究(/HTML )
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
32卷
期数:
2010年第11期
页码:
1155-1157
栏目:
论著
出版日期:
2010-06-15

文章信息/Info

Title:
Correlation of peptidylarginine deiminase 4 gene polymorphism and rheumatoid arthritis
作者:
钟兵方勇飞李华万萍杨菲王勇
第三军医大学:西南医院中西医结合科,基础医学部全军免疫学研究所
Author(s):
Zhong Bing Fang Yongfei Li Hua Wan Ping Yang Fei Wang Yong
Department of Integrated of Traditional Chinese and Western Medicine, Southwest Hospital, Institute of Immunology, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, China
关键词:
肽酰精氨酸脱亚胺基酶4关节炎类风湿基因多态性
Keywords:
peptidylarginine deiminase 4 rheumatoid arthritis gene polymorphism
分类号:
R593.220.2;R394.3;R394.5
文献标志码:
A
摘要:
目的    探讨重庆地区汉族人群肽酰精氨酸脱亚胺基酶4(peptidylarginine deiminase 4,  PADI4)单核苷酸多态性(SNP)与类风湿关节炎(rheumatoid arthritis, RA)之间的关系。    方法    采用聚合酶链反应限制性内切酶片段长度多态性(PCR-RFLP)法检测302例RA患者和322名健康对照者的PADI4 rs874881 SNP多态性,同时检测类风湿因子(Rheumatoid factor,RF)、抗环瓜氨酸肽抗体(cyclic citrullinated peptide, CCP)和抗角蛋白抗体(anti-keratin antibody, AKA)3种RA的特异性自身抗体。    结果    健康对照组PADI4 rs874881 C/C、C/G和G/G基因型频率分别为0.332、0.488和 0.180;RA组分别为0.295、0.474和0.232,与对照组比较,差异无统计学意义(P>0.05)。RA组RF、抗CCP抗体和抗AKA抗体检测阳性率、滴度水平与PADI4 rs874881基因分型均无相关性(P>0.05)。    结论    重庆汉族人群PADI4 rs874881多态性与RA的易感性无关,与RF、CCP及AKA等抗体的阳性率无相关性。
Abstract:
Objective    To investigate the correlation between the peptidylarginine deiminase 4 (PADI4) gene polymorphism and rheumatoid arthritis (RA) in Han population from Chongqing.     Methods    Blood samples of 302 identified RA patients hospitalized in our department from June 2006 to October 2007 and 322 matched normal controls were collected. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) was used to detect the PADI4 rs874881 single nucleotide polymorphisms. Rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) antibody and anti-keratin antibody (AKA) were also detected.     Results    Two alleles, a wild type C and a variant allele G were identified in the PADI4 rs874881. The genotype frequencies of C/C, C/G and G/G were 0.332, 0.488, and 0.180 respectively in the normal controls and 0.295, 0.474, and 0.232 respectively in the RA population. The distribution of the PADI4 rs874881 allele frequencies in Chongqing Han population was in consistence with Hardy-Weinberg equilibrium. There was no statistical difference in the frequencies of PADI4 rs874881 between RA and normal controls. No association was found when patients were classified according to the positive rates of RF, anti-CCP and AKA.     Conclusion    The polymorphism of the PADI4 rs874881 is not associated with rheumatoid arthritis in Han population from Chongqing. No Statistical difference is found between the PADI4 rs874881 polymorphisms and the positive rates of RF, anti-CCP and AKA in RA patients.

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更新日期/Last Update: 2010-06-04