[1]杨爱军,董家鸿.巴马猪胆道盐酸消融对肝功能的影响及病理学变化[J].第三军医大学学报,2010,32(15):1660-1662.
 Yang Aijun,Dong Jiahong.Pathological change in liver lobe of Bama pigs after selective bile duct ablation with hydorchloric acid[J].J Third Mil Med Univ,2010,32(15):1660-1662.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
32卷
期数:
2010年第15期
页码:
1660-1662
栏目:
论著
出版日期:
2010-08-15

文章信息/Info

Title:
Pathological change in liver lobe of Bama pigs after selective bile duct ablation with hydorchloric acid
作者:
杨爱军董家鸿
第三军医大学西南医院全军肝胆外科研究所;解放军总医院肝胆外科
Author(s):
Yang Aijun Dong Jiahong
Department of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, 400038; Department of Hepatobiliary Surgery, General Hospital of PLA, Beijing, 100853, China
关键词:
肝内胆管结石消融盐酸巴马猪
Keywords:
hepatolithus ablation hydrochloric acid Bama pigs
分类号:
R575.62;R322.47;R-332
文献标志码:
A
摘要:
目的    观察以5%盐酸为消融剂,氰基丙烯酸酯为栓塞剂对巴马猪行选择性胆道消融栓塞后靶肝叶病理学改变以及对肝功能的影响。    方法    5头巴马猪左外叶胆道置管,造影后行选择性左外叶胆道消融并栓塞术,检测术后动物的肝脏功能的变化、HE染色和Masson胶原染色观察组织病理改变和术后存活情况。     结果    消融术后动物无死亡。术后3 d血清中ALT、AST、ALP达峰值,其后逐渐恢复正常。术后1周时ALT、AST、ALP与正常无明显异常(P>0.05)。术后1个月,靶肝叶中部及边缘组织胶原染色视野面积百分比及靶肝叶羟脯氨酸含量较正常增加(P<0.05)。    结论    选择性胆道5%盐酸消融及氰基丙烯酸酯栓塞可以导致巴马猪靶肝叶萎缩纤维化。
Abstract:
Objective    To study the pathological changes in liver lobe of Bama pigs after selective bile duct ablation with 5% hydrochloric acid as an as ablation reagent and cyanoacrylate as an embolization reagent.     Methods    A tube was placed in bile duct in swine left liver lobe and selective bile duct ablation was performed. Liver function, pathologic change in liver tissue and survival time of the animals were observed after operation.     Results    No death occurred after operation. The ALT, AST and ALP levels reached their peak in 3 d after operation and became normal in 7 d after operation. The collagen-stained area in center and border of target liver lobe was larger than normal (P<0.05). The level of hydroxyproline was higher in target liver lobe than in normal liver lobe (P<0.05).     Conclusion    Selective bile duct ablation with 5% hydrochloric acid and cyanoacrylate can lead to atrophy of target liver lobe in Bama swine.

参考文献/References:

杨爱军,董家鸿. 巴马猪胆道盐酸消融对肝功能的影响及病理学变化[J].第三军医大学学报,2010,32(15):1660-1662.

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更新日期/Last Update: 2010-08-05