[1]张婧,唐良萏,周敏,等.细胞外基质金属蛋白酶诱导因子、基质金属蛋白酶与血管内皮生长因子在子宫内膜异位症中的表达及意义[J].第三军医大学学报,2010,32(12):1278-1281.
 Zhang Jing,Tang Liangdan,Zhou Min,et al.Expressions and significances of EMMPRIN, MMP-2, MMP-9 and VEGF in endometriosis[J].J Third Mil Med Univ,2010,32(12):1278-1281.
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细胞外基质金属蛋白酶诱导因子、基质金属蛋白酶与血管内皮生长因子在子宫内膜异位症中的表达及意义(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
32卷
期数:
2010年第12期
页码:
1278-1281
栏目:
论著
出版日期:
2010-06-30

文章信息/Info

Title:
Expressions and significances of EMMPRIN, MMP-2, MMP-9 and VEGF in endometriosis
作者:
张婧唐良萏周敏龙行涛
重庆医科大学附属第一医院妇产科
Author(s):
Zhang Jing Tang Liangdan Zhou Min Long Xingtao
Department of Obstetrics and Gynecology, First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China
关键词:
子宫内膜异位症抗原CD147基质金属蛋白酶类血管内皮生长因子类
Keywords:
endometriosisantigens CD147matrix metalloproteinasesvascular endothelial growth factors
分类号:
R711.71;R446.6;R34
文献标志码:
A
摘要:
目的    探讨细胞外基质金属蛋白酶诱导因子(extracellular matrix metalloproteinase inducer,EMMPRIN)、基质金属蛋白酶2(matrix metalloproteinases 2,MMP-2)、基质金属蛋白酶9(MMP-9)和血管内皮生长因子(vascular endothelial growth factor,VEGF)在子宫内膜异位症(endometriosis, EM)中的表达及意义。    方法    应用免疫组化SABC三步法检测57例EM患者子宫内膜组织(57例异位内膜,51例在位内膜)和同期48例非EM患者的正常子宫内膜(对照组)中EMMPRIN、MMP-2、MMP-9及VEGF的表达情况,并对各蛋白表达水平进行相关性分析。    结果    EMMPRIN、MMP-2、MMP-9及VEGF在EM异位内膜表达[分别为(0.723±0.114)、(0.729±0.109)、(0.692±0.089)、(0.704±0.103)]均高于EM在位内膜组[分别为(0.396±0.097)、(0.365±0.023)、(0.349±0.030)、(0.370±0.129)](P<0.05);Pearson相关分析显示,在EM异位内膜中各蛋白表达呈显著正相关(P<0.05)。在EM异位内膜组中EMMPRIN、MMP-2、MMP-9及VEGF表达Ⅲ~Ⅳ期[分别为(0.780±0.058)、(0.779±0.064)、(0.736±0.050)、(0.749±0.059)]高于Ⅰ~Ⅱ期[分别为(0.563±0.070)、(0.588±0.079)、(0.570±0.051)、(0.580±0.100)](P<0.05)。MMP-2在EM在位内膜组表达较对照组高(P<0.05)。    结论    EMMPRIN、MMPs和VEGF在EM中高表达,EMMPRIN-MMPs-VEGF系统上调可能在EM异位内膜种植、侵袭中发挥重要作用。
Abstract:
Objective    To investigate the expressions and significances of extracellular matrix metalloproteinase inducer (EMMPRIN), the matrix metalloproteinases-2,-9 (MMP-2, -9), and the vascular endothelial growth factor (VEGF) in endometriosis (EM).     Methods    The expressions of the EMMPRIN, MMP-2, MMP-9 and VEGF were detected by SABC immunohistochemistry in 57 tissue samples of ectopic endometrium and 51 samples of eutopic endometrium obtained from 57 EM patients, and in 48 normal endometrium from patients with nonendometriosis. Correlation analysis was carried out on the expressions of these proteins and pathologic staging.     Results    The EMMPRIN, MMP-2, MMP-9 and VEGF in ectopic endometrium were expressed at significantly higher levels (0.723±0.114, 0.729±0.109, 0.692±0.089, 0.704±0.103, respectively) than those in eutopic endometrium group (0.396±0.097, 0.365±0.023, 0.349±0.030, 0.370±0.129, respectively, P<0.05). Pearson correlation analysis showed that positive correlation were found between the EMMPRIN, MMP-2, MMP-9 and VEGF in ectopic endometrium group (P<0.05). The expression levels of the EMMPRIN, MMP-2, MMP-9 and VEGF in the stages of Ⅲ to Ⅳ (0.780±0.058, 0.779±0.064, 0.736±0.050, 0.749±0.059, respectively) were significantly higher than those in Ⅰ to Ⅱ (0.563±0.070, 0.588±0.079, 0.570±0.051, 0.580±0.100, respectively) in ectopic endometrium group (P<0.05). The MMP-2 in eutopic endometrium group had significantly higher levels than the control group (P<0.05).     Conclusion    EMMPRIN, MMPs and VEGF are expressed highly in ectopic endometrium. The up-regulation of EMMPRIN-MMPs-VEGF system may play an important role in ectopic endometrium planting and invasion of EM.

参考文献/References:

张婧,唐良萏,周敏,等.细胞外基质金属蛋白酶诱导因子、基质金属蛋白酶与血管内皮生长因子在子宫内膜异位症中的表达及意义[J].第三军医大学学报,2010,32(12):1278-1281.

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更新日期/Last Update: 2010-06-22