[1]张晓燕,王红静,贾西彪.PTEN ⅣS4基因多态性与子宫内膜异位症发病风险的关系[J].第三军医大学学报,2010,32(09):979-981.
 Zhang Xiaoyan,Wang Hongjing,Jia Xibiao.Correlation between PTEN ⅣS4 gene polymorphisms and risk of developing endometriosis[J].J Third Mil Med Univ,2010,32(09):979-981.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
32卷
期数:
2010年第09期
页码:
979-981
栏目:
论著
出版日期:
2010-05-15

文章信息/Info

Title:
Correlation between PTEN ⅣS4 gene polymorphisms and risk of developing endometriosis
作者:
张晓燕王红静贾西彪
四川大学华西第二附属医院妇科
Author(s):
Zhang XiaoyanWang Hongjing Jia Xibiao
Second Affiliated Hospital of Sichuan University, Chengdu, Sichuan Province, 610041, China
关键词:
PTEN基因子宫内膜异位症基因多态性
Keywords:
PTEN geneendometriosispolymorphism
分类号:
R711.71;R394.3
文献标志码:
A
摘要:
目的   探讨PTEN ⅣS4基因多态性与子宫内膜异位症(endometriosis,EMS)的关系。   方法   应用聚合酶链反应限制性内切酶片段长度多态性(PCRRFLP)技术,分析86例子宫内膜异位症患者及64例对照者的PTEN ⅣS4基因多态性。   结果   病例组及对照组PTEN ⅣS4基因野生型(-/-)、杂合型(-/+)、突变型(+/+)频率分别为11.6%、83.7%、4.7%及10.9%、73.5%、15.6%,等位基因-、+频率分别为53.5%、46.5%及47.7%、52.3%,2组比较差异均无统计学意义(P>0.05)。合并PTEN ⅣS4基因杂合型(-/+)和野生型(-/-)与突变型(+/+)相比,携带PTEN ⅣS4突变型基因(+/+)可降低子宫内膜异位症的发病风险(OR=3.796,95%CI=1.132 8~12.722 7,P<0.05)。   结论   PTEN ⅣS4基因多态性中,突变型基因(+/+)是子宫内膜异位症发生的保护性因素。
Abstract:
Objective   To study the correlation between PTEN gene polymorphisms and endometriosis (EMS).    Methods   PTEN ⅣS4 polymorphisms in 86 EMS patients and 64 healthy controls were analyzed by polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP).    Results   The frequency of wild PTEN ⅣS4 (-/-),heterozygous PTEN ⅣS4 (-/+), and mutant PTEN ⅣS4 (+/+) was 11.6%,83.7%,4.7% respectively in EMS patients and 10.9%,73.5%,15.6% respectively in healthy controls. The frequency of alleles (- and +) was 53.5% and 46.5% respectively in EMS patients and 47.7%,52.3% respectively in controls (P>0.05).The risk of developing EMS was lower in patients carrying mutant PTEN ⅣS4 (+/+) than in those carrying wild PTEN ⅣS4 (-/-), heterozygous PTEN ⅣS4 (-/+) and mutant PTEN ⅣS4 (+/+) (OR= 3.796, 95%CI=1.132 8 to 12.722 7, P<0.05).    Conclusion   Mutant PTEN ⅣS4 (+/+) can reduce the risk of developing EMS.

参考文献/References:

张晓燕, 王红静, 贾西彪.PTEN ⅣS4基因多态性与子宫内膜异位症发病风险的关系[J].第三军医大学学报,2010,32(9):979-981.

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更新日期/Last Update: 2010-05-07