[1]李婕,刘政,张婵,等.超声空化致犬前列腺损伤的形态学观察[J].第三军医大学学报,2009,31(23):2327-2329.
 LI Jie,LIU Zheng,ZHANG Chan,et al.Impact of ultrasound-induced microbubble cavitation on prostate injury in dogs[J].J Third Mil Med Univ,2009,31(23):2327-2329.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
31卷
期数:
2009年第23期
页码:
2327-2329
栏目:
论著
出版日期:
2009-12-15

文章信息/Info

Title:
Impact of ultrasound-induced microbubble cavitation on prostate injury in dogs
作者:
李婕刘政张婵方针强赵洋周仁杰叶钢
第三军医大学新桥医院超声科
Author(s):
LI Jie LIU Zheng ZHANG Chan FANG Zhen-qiang ZHAO Yang ZHOU Ren-jie YE Gang
Department of Ultrasonography, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
关键词:
前列腺微泡超声空化
Keywords:
prostate microbubble ultrasound cavitation
分类号:
R329.24;R454.3;R697.3
文献标志码:
A
摘要:
目的    探讨微泡激励的超声空化效应对正常犬前列腺组织的损伤作用。    方法    15只健康成年雄性犬随机分为超声微泡组、单纯超声组和微泡假照组。在开腹情况下,联合经静脉推注微泡0.1 ml/kg和脉冲式超声辐照前列腺10 min,治疗后获取前列腺组织,进行大体、光镜和电镜检查。    结果    超声微泡组,光镜见前列腺细胞间隙可见显著的微血管破裂、大量出血和血肿形成;电镜可见细胞器肿胀,桥粒等细胞连接断裂,红细胞露出。    结论    超声激励的微泡空化效应对犬前列腺有明显的机械损伤作用。
Abstract:
Objective    To explore the damage of ultrasound (US)-induced microbubble (MB) cavitation on the prostate in dogs.     Methods    A total of 15 dogs were randomly divided into 3 groups, US+MB group, simple US group and MB group. After abdominal opening to expose the prostates, the dogs of US+MB group received an intravenous injection of self-made MB 0.1 ml/kg and a pulsed focused ultrasound radiation  for 10 min at the same time. The animals of simple US group were given normal saline injection and the radiation, while those of the MB group were injected with MB at the same dose but no ultrasound radiation. The prostates was removed immediately after radiation for gloss observation, light and electron microscopy.     Results    Microvessle rupture, hemorrhage and hematoma in the prostate were found in the US+MB group. And swollen organelles, broken intercellular bridge and infiltrated erythrocyte were observed too.     Conclusion    Ultrasound-induced MB cavitation causes obvious mechanical damage in the prostate tissue of dogs.

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更新日期/Last Update: 2009-11-23