[1]沈光建,许民辉,邹咏文,等.泌乳素腺瘤伽玛刀治疗后早期内分泌功能的改变及意义[J].第三军医大学学报,2009,31(21):2084-2085.
 SHEN Guang-jian,XU Min-hui,ZOU Yong-wen,et al.Alternation and significance of endocrinal function for prolactinoma in early stage after gamma knife radiosrugery[J].J Third Mil Med Univ,2009,31(21):2084-2085.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
31卷
期数:
2009年第21期
页码:
2084-2085
栏目:
论著
出版日期:
2009-11-15

文章信息/Info

Title:
Alternation and significance of endocrinal function for prolactinoma in early stage after gamma knife radiosrugery
作者:
沈光建许民辉邹咏文耿明英李飞鹏
第三军医大学大坪医院野战外科研究所神经外科
Author(s):
SHEN Guang-jian XU Min-hui ZOU Yong-wen GENG Ming-ying LI Fei-peng
Department of Neurosurgery, Institute of Surgery Research, Daping hospital, Third Military Medical University, Chongqing 400042, China
关键词:
伽玛刀泌乳素腺瘤内分泌功能
Keywords:
gamma knife radiosurgery prolactinoma endocrinological function
分类号:
R335.1;R730.56;R736.4
文献标志码:
A
摘要:
目的   探讨泌乳素腺瘤患者伽玛刀治疗后早期内分泌功能的变化规律及意义。   方法   对有完整近期随访资料的27例患者进行回顾分析,调查其临床症状和泌乳素(prolactin, PRL)水平在治疗后6个月的动态变化,并评估该变化可能的临床意义。   结果   在随访的6个月中,临床症状短暂或持续好转者24例(89%),PRL水平短暂或持续降低21例(78%)。临床症状好转和PRL下降主要发生于治疗后前2个月。临床症状好转率及PRL水平在治疗后前2个月与其他月份间比较有显著差异(P<0.05)。   结论   泌乳素腺瘤伽玛刀治疗后内分泌功能紊乱的改善在2个月内更为显著,应被视为育龄女性着孕或避孕的重点时期之一。
Abstract:
Objective   To explore the changes of endocrinal function and their roles in early stage of prolactinoma after gamma knife radiosurgery (GKRS).   Methods   A total of 27 prolactinoma patients admitted during November 1997 to November 2007 with intact early stage followed-up data were retrospectively reviewed. The dynamical changes for clinical symptoms, and prolactin (PRL) levels during 6 months after GKRS were investigated. The possible clinical roles for the changes were evaluated.   Results   During 6 months after GKRS, the clinical symptoms were improved in 24 patients (89%) and PRL level was decreased in 21 patients (78%) transiently or persistently. The improvement in the symptoms and the reduction in PRL level occurred mostly in the first 2 months after GKS. In Chi-square testing and t  testing showed that there was significant difference between the first or second month and most of the other month after GKRS on improvement rate in the symptoms and PRL levels.   Conclusion   Endocrinal malfunction of prolactinoma can be ameliorated more significantly during the first 2 months after GKS, so this period should be regarded as one of key-stages for pregnancy or contraception in reproductive age females.

参考文献/References:

沈光建, 许民辉, 邹咏文, 等. 泌乳素腺瘤伽玛刀治疗后早期内分泌功能的改变及意义[J]. 第三军医大学学报,2009,31(21):2084-2085.

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更新日期/Last Update: 2009-11-02