[1]傅勇,胡华梅,谭益,等.基质金属蛋白酶-9基因多态性与食管鳞状细胞癌易感性的关联研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(12):1131-1134.
 FU Yong,HU Hua-mei,TAN Yi,et al.Correlation between the polymorphism of matrix metalloproteinase-9 and esophageal squamous cell carcinoma patients in Southwest China[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(12):1131-1134.
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基质金属蛋白酶-9基因多态性与食管鳞状细胞癌易感性的关联研究(/HTML )
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
31卷
期数:
2009年第12期
页码:
1131-1134
栏目:
论著
出版日期:
2009-06-30

文章信息/Info

Title:
Correlation between the polymorphism of matrix metalloproteinase-9 and esophageal squamous cell carcinoma patients in Southwest China
作者:
傅勇胡华梅谭益唐胜军熊刚杨康白云
第三军医大学:西南医院胸心外科,基础医学部医学遗传学教研室;重庆市三峡中心医院胸外科
Author(s):
FU Yong HU Hua-mei TAN Yi TANG Sheng-jun XIONG Gang YANG Kang BAI Yun
Department of Thoracic and Cardiac Surgery, Southwest Hospital, Department of Medical Genetics, College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038; Department of Thoracic and Cardiac Surgery, Chongqing Three Gorges Center Hospital, Chongqing 404000, China
关键词:
食管鳞状细胞癌基质金属蛋白酶-9单核苷酸多态性易感性
Keywords:
esophageal squamous cell carcinoma matrix metalloproteinsase-9 single nucleotide polymorphism susceptibility
分类号:
R394.3;R730.23;R735.1
文献标志码:
A
摘要:
目的   研究基质金属蛋白酶-9(matrix metalloproteinsase-9,MMP-9)基因多态性与中国西南地区人群食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)的关联性。   方法   应用聚合酶链反应-限制性片段长度多态性(polymerase chain reaction-restriction fragment length polymorphisms,PCR-RFLPs)方法检测235例食管鳞状细胞癌病例组及300例健康对照组的MMP-9 R279Q基因多态性的分布情况。   结果   ESCC患病组和健康对照组MMP-9 279R、279Q等位基因频率分别为57.7%、42.3%和51.5%、48.5%,二者有显著性差异(χ2=4.08,P=0.04);MMP-9 279R/R基因型频率在ESCC病例组(40.5%)中显著高于对照组(29.0%)(χ2=20.08,P=0.01);当按年龄进行分层分析时,与Q/Q基因型相比,R/R基因型能明显增加50岁以下人群ESCC的发病风险(校正OR值为3.39,95%CI为1.23~9.29)。   结论   携带有MMP-9 279R等位基因的人群与ESCC易感性有显著关联性,MMP-9 279R/R基因型可增加患ESCC的风险。在中国西南地区人群中MMP-9 R279Q基因多态性可能是ESCC发生的危险因素之一。
Abstract:
Objective   To investigate the correlation between the single nucleotide polymorphism (SNP) of Matrix metalloproteinsase-9 (MMP-9) gene and esophageal squamous cell carcinoma patients in Southwest China.    Methods   The polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLPs) technique was applied to analyze the MMP-9 R279Q polymorphism in normal group (300) and ESCC group (235).     Results   Frequencies of the MMP-9 279R and 279Q allele distribution in ESCC patients and healthy control were 57.7%, 42.3% and 51.5%, 48.5%, respectively (χ2=4.08, P=0.04). The frequency of the R/R genotype in the MMP-9 gene polymorphism increased significantly in ESCC patients (40.5%) as compared with that in the controls (29.0%) (χ2=20.08, P=0.01). Age-stratified analysis showed R/R genotype significantly increased the risk of ESCC in individuals younger than 50 years (adjusted OR=3.39, 95%CI=1.23~9.29).     Conclusion   The R allele of MMP-9 gene R279Q might be associated with the increased susceptibility to ESCC. The R homozygote might increase the risk of ESCC. Our results indicated that MMP-9 R279Q polymorphism might be associated with genetic susceptibility to ESCC in Southwest Chinese population.

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更新日期/Last Update: 2009-05-31