[1]赵先英,刘毅敏,肖湘,等.乳酸-羟基乙酸共聚物缓释纳米微球的制备及体外释药评价[J].第三军医大学学报,2009,31(12):1155-1157.
 ZHAO Xian-ying,LIU Yi-min,XIAO Xiang,et al.Preparation of LIDA-PLGA slow release nanospheres and evaluation of the release properties in vitro[J].J Third Mil Med Univ,2009,31(12):1155-1157.
点击复制

乳酸-羟基乙酸共聚物缓释纳米微球的制备及体外释药评价(/HTML )
分享到:

《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
31卷
期数:
2009年第12期
页码:
1155-1157
栏目:
论著
出版日期:
2009-06-30

文章信息/Info

Title:
Preparation of LIDA-PLGA slow release nanospheres and evaluation of the release properties in vitro
作者:
赵先英刘毅敏肖湘粟永萍贺建李明春张肖莎
第三军医大学:医学检验系暨药学院化学教研室,军事预防医学院防原医学教研室,全军复合伤研究所,创伤、烧伤与复合伤研究重点实验室,学员旅二队
Author(s):
ZHAO Xian-ying LIU Yi-min XIAO Xiang SU Yong-ping HE Jian LI Ming-chun ZHANG Xiao-sha
Department of Chemistry, College of  Laboratory Medicine and Pharmacy, State Key Laboratory of Trauma, Burns and Combined Injuries, Institute of Combined Injury, College of Military Preventive Medicine,2nd Student Team, Third Military Medical University, Chongqing 400038, China
关键词:
利多卡因聚乳酸羟基乙酸纳米微球缓释
Keywords:
lidocaine poly(lactic-co-glycolic acid) nanosphere slow release
分类号:
R914.2;R944.9;R96
文献标志码:
A
摘要:
目的   以乳酸-羟基乙酸共聚物[poly(lactic-co-glycolic acid),PLGA]为材料,制备缓释局麻药利多卡因(Lidocaine,LID)-PLGA长效缓释微球。   方法   采用乳化溶媒挥发法制备微球;采用紫外分光光度法测定微球载药量、包封率和体外药物释放。   结果   纳米微球形态光滑圆整,球体大小均匀,微球粒径为(174.5±15.2)nm,微球载药量和包封率分别为12.48%和54.30%,微球体外释放符合Higuchi方程,半衰期t1/2=3.45 d。   结论   LID-PLGA纳米微球具有明显缓释作用。
Abstract:
Objective   To prepare LID-PLGA nanospheres (LID-PLGA-Ns) with poly(lactic-co-glycolic acid) (PLGA) for the study of the release properties in vitro.    Methods   The nanospheres were prepared by the solvent evaporation method. The drug-loading, encapsulation efficiency and release in vitro were determined by ultraviolet-visible spectrophotometry.    Results   The prepared LID-PLGA-Ns were even and uniform spheres with mean particle size of (174.5±15.2)nm in diameter. The drug loading and encapsulation efficiency were 12.48% and 34.30%, respectively. The in vitro release profile of nanospheres was found to agree with Higuchi equation, with  t1/2=3.45 d .    Conclusion   The prepared nanospheres loaded with lidocaine are of slow-release function in vitro.

参考文献/References:

赵先英,刘毅敏,肖湘,等. 乳酸-羟基乙酸共聚物缓释纳米微球的制备及体外释药评价[J]. 第三军医大学学报,2009,31(12):1155-1157.

相似文献/References:

[1]向平,宋银子,陈沅,等.提高大鼠心肌梗死模型成功率及存活率的研究[J].第三军医大学学报,2008,30(04):329.
 XIANG Ping,SONG Yin-zi,CHEN Yuan,et al.Methods on enhancing success rate and survival rate of rat model of myocardial infarction[J].J Third Mil Med Univ,2008,30(12):329.
[2]陈晓良,周培华,张斌,等.利多卡因在肝血管瘤介入治疗中的价值[J].第三军医大学学报,2007,29(06):553.
 CHEN Xiao-liang,ZHOU Pei-hua,ZHANG Bin,et al.Value of lidocaine in interventional therapy for liver hemangioma[J].J Third Mil Med Univ,2007,29(12):553.
[3]赵先英,刘毅敏,肖湘,等.均匀试验设计在利多卡因缓释纳米微球制备中的应用[J].第三军医大学学报,2010,32(21):2300.
 Zhao Xianying,Liu Yimin,Xiao Xiang,et al.Applications of uniform design method in preparation of LIDA-PLGA sustained release nanospheres[J].J Third Mil Med Univ,2010,32(12):2300.
[4]王志仪,陈一丁,李文瑶,等.异丙酚复合不同药物在门诊无痛纤维支气管镜检查中的麻醉效果分析[J].第三军医大学学报,2014,36(13):1440.
[5]傅洪,曲世界,唐曦,等.利多卡因与丙泊酚混合使用对丙泊酚注射痛防治效果观察[J].第三军医大学学报,2015,37(06):587.
[6]夏华琼,吴庆蓉.利多卡因宫颈、宫腔麻醉行人工流产术268例临床观察[J].第三军医大学学报,2004,26(13):0.[doi:10.16016/j.1000-5404.2004.13.039 ]
[7]朱圆,熊亚,李红雨,等.罗哌卡因浸润麻醉对椎管内分娩镇痛下自然分娩后会阴疼痛镇痛效果的随机对照研究[J].第三军医大学学报,2019,41(07):691.
 ZHU Yuan,XIONG Ya,LI Hongyu,et al.Pain relief effects of ropivacaine for perineal pain during vaginal delivery under epidural labor analgesia: a doubleblind randomized controlled trial[J].J Third Mil Med Univ,2019,41(12):691.

更新日期/Last Update: 2009-05-31