[1]孙磊,安辉,郑有科,等.模拟密闭舱室烟雾吸入染毒装置的研制[J].第三军医大学学报,2009,31(04):290-293.
 SUN Lei,AN Hui,ZHENG You-ke,et al.Development of a smoke inhalation unit simulating airtight cabin[J].J Third Mil Med Univ,2009,31(04):290-293.
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模拟密闭舱室烟雾吸入染毒装置的研制(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
31卷
期数:
2009年第04期
页码:
290-293
栏目:
论著
出版日期:
2009-02-28

文章信息/Info

Title:
Development of a smoke inhalation unit simulating airtight cabin
作者:
孙磊安辉郑有科曹佳
第三军医大学军事预防医学院军事毒理学教研室
Author(s):
SUN Lei AN Hui ZHENG You-ke CAO Jia
Department of Military Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China
关键词:
密闭舱室烟雾吸入染毒装置大鼠
Keywords:
airtight cabin smoke inhalation carboxyhemoglobin rat
分类号:
R-331;R827.12
文献标志码:
A
摘要:
目的    研制一种密闭舱室烟雾吸入染毒装置。    方法    自行设计烟雾发生箱、染毒箱和循环管道,集成为一套完整的烟雾吸入染毒装置,实现燃烧与染毒的分离。选用某种军用密闭舱室内9种非金属材料,按照实际用量比燃烧产生烟雾后,经循环管道引至染毒箱中染毒动物。42只SD大鼠完全随机分为正常对照组(n=7)及3个染毒组,染毒时间依次为5 min(n=7)、10 min(n=21)及15 min(n=7)。检测混合烟雾中CO和O2浓度及酸性气体含量,测定10 min组大鼠染毒后即刻尾静脉血中COHb%,并观察染毒后动物大体情况及7 d内死亡率。    结果    烟雾浓度随着燃烧时间的延长而增加,且重复检测各时间点的烟雾浓度恒定,动物中毒程度随着染毒时间的延长而加重,染毒10 min组大鼠COHb%显著升高,且3批次动物COHb%重复性好。    结论    本装置能成功模拟密闭舱室内烟雾发生及中毒情况,且动物染毒损伤的重复性较好。
Abstract:
Objective    To develop a smoke inhalation unit simulating airtight cabin.     Methods    We designed a completed smoke inhalation unit composed of smoke generation cabinet, circulation pipe line and inhalation cabinet. The unit was verified with 42 SD rats inhaled with smoke generated from combustion of 9 nonmetal materials used in a  airtight cabin. The rats were randomly divided into experimental group and 5 inhalation groups, with 7 rats in each group. The concentrations of CO, O2 and acid gases in the inhalation cabinet were analyzed. The activities and mortality of the rats within 7 d were recorded. COHb% of 21 rats in ten-minute inhalation groups was detected quickly after exposure.     Results    The concentration of smoke increased with the time of combustion and kept constant on each time point. The degree of intoxication in rats increased with the time of inhalation, and COHb% of ten-minute inhalation groups showed good reproducibility.     Conclusion    Our developed unit can simulate the smoke generation and intoxication in airtight cabin and keep good reproducibility of animal injury.

参考文献/References:

孙磊, 安辉, 郑有科, 等. 模拟密闭舱室烟雾吸入染毒装置的研制[J]. 第三军医大学学报, 2009, 31(4):290-293.

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更新日期/Last Update: 2009-02-11