[1]李涛,刘良明,刁有芳,等.不同液体对失血性休克大鼠复苏效果的影响[J].陆军军医大学学报(原第三军医大学学报),2009,31(06):467-469.
 LI Tao,LIU Liang-ming,DIAO You-fang,et al.Effects of different resuscitation fluids on hemorrhagic shock in rats[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(06):467-469.
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
31卷
期数:
2009年第06期
页码:
467-469
栏目:
论著
出版日期:
2009-03-30

文章信息/Info

Title:
Effects of different resuscitation fluids on hemorrhagic shock in rats
作者:
李涛刘良明刁有芳廖自福范小青陈凤
第三军医大学大坪医院野战外科研究所第二研究室,创伤、烧伤与复合伤国家重点实验室
Author(s):
LI Tao LIU Liang-ming DIAO You-fang LIAO Zi-fu FAN Xiao-qing CHEN Feng
State Key Laboratory of Trauma, Burns and Combined Injury, Department 2, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
关键词:
失血性休克大鼠羟乙基淀粉高渗氯化钠右旋糖酐
Keywords:
hemorrhagic shock hydroxyethyl starch Lactated Ringer’s fluid rats
分类号:
R457.2;R605.971;R973.5
文献标志码:
A
摘要:
目的    探讨不同液体输注对失血性休克大鼠复苏效果的影响。    方法    用SD大鼠制作35%放血失血性休克模型,以乳酸林格氏液(LR)、羟乙基淀粉130(HES130)、6%右旋糖酐40、高渗氯化钠右旋糖酐(HSD)、LR+右旋糖酐(体积比2∶1)和LR+6%HES(体积比2∶1)复苏休克动物至适宜血压(80 mmHg)1 h后,观察其对失血性休克大鼠平均动脉血压(mean arterial blood pressure, MAP)、左心室收缩压(left intraventricular systolic pressure, LVSP)、左心室压力上升或下降的最大速率(the maximal change rate of left intraventricular pressure, ±dp/dtmax)的影响,同时观察血气指标和存活时间的变化。    结果    输注LR、HES130、LR+6%HES后MAP能较好地维持在80 mmHg水平,而右旋糖酐40、LR+右旋糖酐以及HSD输注后MAP不能达到80 mmHg。HES130、LR+6%HES输注后LVSP和±dp/dtmax明显增加,而输注右旋糖酐、LR+右旋糖酐以及HSD后,LVSP和±dp/dtmax LR组显著降低(P<0.05),以输注HSD后最低。输注HSD后动物存活时间最短,输注HES130和LR+6%HES后动物存活时间较其他组长(P<0.05)。HES130、LR+6%HES改善血气效果较其他各组好。    结论    不同液体对失血性休克大鼠复苏效果存在明显差异,以HES130和LR+6%HES效果较好,HSD效果较差。
Abstract:
Objective    To investigate the effect of different fluids on the resuscitation of hemorrhagic shock in rats.     Methods    SD rats were inflicted by 35% hemorrhage to make moderate hemorrhagic shock model. Effects of different resuscitation fluids including Lactated Ringer’s (LR), hydroxyethyl starch 130 (HES130), 6% Dextran40, 7.5% NaCl/6% Dextran40 (HSD), LR+6% Dextran40 and LR+6%HES on mean arterial blood pressure (MAP), left intraventricular systolic pressure (LVSP), the maximal change rate of left intraventricular pressure (±dp/dtmax) in hemorrhagic shock rats were observed. Blood gas and survival time were also observed.     Results    HES130, HES130+LR effectively maintained the MAP at 80 mmHg, but Dextran40, LR+Dextran and HSD did not. HES130 and LR+6%HES improving hemodynamic parameters and blood gas were significantly superior to Dextran40, LR+Dextran40 and HSD. Animal survival time of HES130 and LR+6%HES group were significantly longer than other groups. Among all groups, the animal survival time in HSD group was shortest.     Conclusion    Different resuscitation fluids exert obvious different effect on resuscitating hemorrhagic shock. Among these fluids observed in the present study, HES130 and LR+6%HES shows better resuscitative effects.

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更新日期/Last Update: 2009-03-24