[1]李德志,周一兵,万久庆,等.全身照射用于造血干细胞移植前预处理78例临床分析[J].第三军医大学学报,2009,31(03):254-256.
 LI De-zhi,ZHOU Yi-bing,WAN Jiu-qing,et al.Total body irradiation before hematopoietic blood stem cells transplantation: clinical analysis of 78 cases[J].J Third Mil Med Univ,2009,31(03):254-256.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
31卷
期数:
2009年第03期
页码:
254-256
栏目:
论著
出版日期:
2009-02-15

文章信息/Info

Title:
Total body irradiation before hematopoietic blood stem cells transplantation: clinical analysis of 78 cases
作者:
李德志周一兵万久庆陈正堂
第三军医大学新桥医院全军肿瘤诊治研究所
Author(s):
LI De-zhi ZHOU Yi-bing WAN Jiu-qing CHEN Zheng-tang
Cancer Research Center, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
关键词:
全身照射干细胞移植血液肿瘤
Keywords:
total body irradiation blood stem cell transplantation malignant tumors in blood
分类号:
R457.7; R815.6; R816.3
文献标志码:
A
摘要:
目的    回顾性分析全身照射(total body irradiation,TBI)用于造血干细胞移植治疗白血病和恶性淋巴瘤的作用、照射剂量及并发症。    方法    2002年5月至2007年12月本院有78例造血干细胞移植患者使用了TBI作为预处理。采用直线加速器8MVX线,吸收剂量率为4.5~5.0 cGy/min,照射剂量为7~11 Gy,连续2 d完成。78例中,55例采用传统的先大剂量化疗再TBI的预处理方案,23例采用先TBI再大剂量化疗的顺序。    结果    78例使用了TBI作为预处理的病例移植全部成功,无严重的放射性肺炎等并发症发生。    结论    TBI预处理方案是安全、有效的;采用先TBI再大剂量化疗的顺序,可有效减少TBI的即时反应,采用直线加速器做TBI对设备有更高的要求。
Abstract:
Objective    To analyze the efficacy, dose and complications of total body irradiation (TBI) for patients to receive hematopoietic stem cell transplantation (HSCT) in the treatment of leukemia and malignant lymphoma.     Methods    From May 2002 to February 2007, 78 cases with leukemia or malignant lymphoma received the TBI before HSCT in our department. All the patients were irradiated with linear accelerator in 2 consecutive days at a total dose of 7 to 11 Gy, dose rate of 4.5 to 5.0 cGy/min, once per day. Among them, 55 cases received traditional high-dose chemotherapy before radiotherapy, and the other 23 cases got TBI first followed by high-dose chemotherapy.     Results    All the cases used TBI prior to transplantation was successful, and no serious complication such as radiation pneumonitis was observed.     Conclusion    Our TBI regime is a safe and effective pretreatment for HSCT. TBI used before the large doses of the chemotherapy is recommended because it is proved to be effective, without affecting the survival rate, and of lesser TBI reaction and of lesser preparation work for irradiation to radiotherapist. More attention should be paid when the linear accelerator is employed for TBI.

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更新日期/Last Update: 2009-02-11