[1]李晋涛,陈正琼,梁志清,等.Eppin抗原的二级结构分析B细胞表位预测[J].第三军医大学学报,2008,30(24):2254-2257.
 LI Jin-tao,CHEN Zheng-qiong,LIANG Zhi-qing,et al.Prediction of B cell epitope for Eppin antigen[J].J Third Mil Med Univ,2008,30(24):2254-2257.
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Eppin抗原的二级结构分析B细胞表位预测(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第24期
页码:
2254-2257
栏目:
论著
出版日期:
2008-12-30

文章信息/Info

Title:
Prediction of B cell epitope for Eppin antigen
作者:
李晋涛陈正琼梁志清阎萍何畏吴玉章
第三军医大学:基础医学部全军免疫学研究所,西南医院妇产科
Author(s):
LI Jin-tao CHEN Zheng-qiong LIANG Zhi-qing YAN Ping HE Wei WU Yu-zhang
Institute of Immunology, College of Medicine; Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
关键词:
Eppin抗原B 细胞表位
Keywords:
Eppin antigen B cell epitope
分类号:
R341;R392.2;R392.7
文献标志码:
A
摘要:
目的    分析Eppin抗原的二级结构并预测其B细胞表位。    方法    联合运用多种方法对Eppin的二级结构和表面特性,如亲水性、理化性质、可及性、免疫原性和可塑性等方面进行分析,预测其抗原表位。    结果    Eppin存在多个潜在的抗原表位位点,可能的蛋白质抗原表位区域:14~23,30~44,48~54,56~68,78~85,97~106,109~116,125~132。体外实验证明,所预测抗原表位区域基本能与免疫抗血清发生抗原特异性反应。    结论    应用多参数成功预测了Eppin抗原的B细胞表位。
Abstract:
Objective    To predict the B cell epitope for Eppin antigen.     Methods    The secondary structure and surface properties of Eppin, such as physical and chemical properties, hydrophilicity, accessibility, antigenicity and plasticity, were analyzed by a variety of methods.     Results    Many distinct antigenic epitopes in Eppin were identified by computation, the possible location of which is in the regions of 14-23, 30-44, 48-54, 56-68, 78-85, 97-106, 109-116, and 125-132.     Conclusion    The B cell epitope for Eppin is successfully predicted.
更新日期/Last Update: 2008-11-12