[1]闫纪强,刘东方,周厚地,等.福辛普利对糖尿病大鼠胰腺组织氧化应激的影响[J].陆军军医大学学报(原第三军医大学学报),2009,31(02):160-162.
 YAN Ji-qiang,LIU Dong-fang,ZHOU Hou-di,et al.Effect of Fosinopril on oxidative stress of pancreatic tissue in diabetic rats[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(02):160-162.
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福辛普利对糖尿病大鼠胰腺组织氧化应激的影响(/HTML )
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
31卷
期数:
2009年第02期
页码:
160-162
栏目:
论著
出版日期:
2009-01-30

文章信息/Info

Title:
Effect of Fosinopril on oxidative stress of pancreatic tissue in diabetic rats
作者:
闫纪强刘东方周厚地徐鑫
重庆医科大学附属第二医院内分泌科
Author(s):
YAN Ji-qiang LIU Dong-fang ZHOU Hou-di XU Xin
Department of Endocrinology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
关键词:
糖尿病硝基酪氨酸福辛普利
Keywords:
diabetes mellitus nitrotyrosine Fosinopril
分类号:
R322.491;R587.1;R972
文献标志码:
A
摘要:
目的    研究糖尿病大鼠胰腺组织氧化应激的情况及福辛普利干预后胰岛功能及胰腺组织的免疫组化改变。    方法    21只大鼠分对照组、糖尿病组、福辛普利干预组,糖尿病组用高脂进行喂养制作糖尿病模型,干预组喂以福辛普利(5 mg/kg),在病程不同时点测定血糖、体质量及胰腺组织中硝基酪氨酸的含量,并观察胰腺组织免疫组化改变。    结果    糖尿病组与正常对照组胰腺硝基酪氨酸含量比较明显增高(P<0.01);福辛普利干预组与糖尿病组胰腺中硝基酪氨酸含量比较明显降低,氧化应激水平亦降低(P<0.05)。    结论    糖尿病大鼠胰腺组织的氧化应激存在异常,福辛普利对糖尿病大鼠胰腺氧化应激存在抑制作用。
Abstract:
Objective    To study the oxidative stress in diabetic rat pancreas, and the changes of islet function after intervention of Fosinopril.     Methods    Wistar rats were randomly divided into control group, diabetes group and Fosinopril treated group. The diabetes was induced by feeding the rats from diabetes group and Fosinopril group with high fat diet for 3 weeks and then once intraperitoneal injection of STZ (35 mg/kg), while additionally Fosinopril (5 mg/kg) was given to the diabetic rats in Fosinopril treated group. Blood glucose, body weight, nitrotyrosine levels in pancreatic tissues were detected and the histopathologic changes of pancreatic tissues were observed.     Results    Nitrotyrosine content was significantly higher in diabetes group than that in control group (P<0.01). Nitrotyrosine content and the level of oxidative stress were significantly decreased in Fosinopril treated group compared with those in diabetes group (P<0.05).     Conclusion    Nitrotyrosine content is abnormal in diabetic rats, and Fosinopril can significantly inhibit the oxidative stress in pancreas.

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更新日期/Last Update: 2009-01-08