[1]周世文,刘世杰.牛磺酸和茵陈素对顺铂引起的原代培养肾小管上皮细胞内游离Ca2+浓度变化的影响[J].第三军医大学学报,2002,24(01):0.[doi:10.16016/j.1000-5404.2002.01.036 ]
 ZHOU Shi Wen,LIU Shi jie.[J].J Third Mil Med Univ,2002,24(01):0.[doi:10.16016/j.1000-5404.2002.01.036 ]
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牛磺酸和茵陈素对顺铂引起的原代培养肾小管上皮细胞内游离Ca2+浓度变化的影响(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
24卷
期数:
2002年第01期
页码:
0
栏目:
默认栏目
出版日期:
2002-01-30

文章信息/Info

作者:
周世文;刘世杰;
第三军医大学附属新桥医院临床药理基地;第三军医大学附属新桥医院临床药理基地重庆400037;重庆400037;
Author(s):
ZHOU Shi Wen LIU Shi jie
Department of Clinical Pharmacology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
关键词:
顺铂牛磺酸茵陈素肾小管上皮细胞细胞内游离Ca2+浓度
分类号:
R965
DOI:
10.16016/j.1000-5404.2002.01.036
摘要:
目的 研究牛磺酸、茵陈素对顺铂引起的原代培养肾小管上皮细胞 (PTC)内游离Ca2 +浓度变化的影响。方法 在体外培养PTC、顺铂与PTC共同保温 2 4h ,牛磺酸、茵陈素分别提前与PTC作用 2 4h ,然后再加入顺铂 ( 2 6 μmol·L- 1 )共同保温 2 4h。采用Fura 2 AM测细胞内游离Ca2 +浓度。结果 顺铂 ( 13,2 6 ,5 2 μmol·L- 1 )升高PTC细胞内游离Ca2 +浓度 ,牛磺酸 ( 1,10g·L- 1 )和茵陈素 ( 4 ,8mg·L- 1 ) ,可拮抗顺铂导致的PTC细胞内游离Ca2 +浓度超载。结论 顺铂可引起原代培养肾小管上皮细胞内Ca2 +超载 ,牛磺酸、茵陈素能拮抗顺铂导致的细胞内Ca2 +超载 ,起到细胞保护作用。

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更新日期/Last Update: 2002-01-30