[1]胡望平,冯福英,叶桂云,等.血清c-PSA及 C/T在提高前列腺癌诊断特异性中的探讨[J].第三军医大学学报,2007,29(18):1815-1817.
 HU Wang-Ping,FENG Fu-ying,YE Gui-yun,et al.Serum complexed-PSA and ratio of complexed/total PSA to improve diagnostic specificity on identifying prostate cancer[J].J Third Mil Med Univ,2007,29(18):1815-1817.
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血清c-PSA及 C/T在提高前列腺癌诊断特异性中的探讨(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第18期
页码:
1815-1817
栏目:
论著
出版日期:
2007-09-30

文章信息/Info

Title:
Serum complexed-PSA and ratio of complexed/total PSA to improve diagnostic specificity on identifying prostate cancer
作者:
胡望平冯福英叶桂云肖少林章宏斌王海林郑苗
南京军区福州总医院生化科;福州市福建省建新医院检验科;南平市第一医院检验科
Author(s):
HU Wang-Ping FENG Fu-ying YE Gui-yun  XIAO Shao-lin ZHANG Hong-bin WANG Hai-lin ZHENG Miao
Department of Clinical Chemistry, General Hospital of Fuzhou Command of PLA, Department of Medical Laboratory, Jianxin Hospital of Fujian Province, Fuzhou 350025;Department of Medical Laboratory, First Hospital of Nanping, Nanping 353000, China
关键词:
复合前列腺特异性抗原前列腺癌良性前列腺增生前列腺特异性抗原
Keywords:
complexed prostate special antigen prostate cancer benign prostate hyperplasia total prostate special antigen
分类号:
R392.11;R730.43;R737.25
文献标志码:
A
摘要:
目的 研究复合前列腺特异性抗原(c-PSA)及相关指标在鉴别诊断前列腺癌和良性前列腺增生中的应用价值,提高前列腺癌诊断特异性。 方法 分析了70例男性,经B超、病理诊断证实18例为前列腺癌(PCa),27例为良性前列腺增生(BPH),25例为正常对照组。Bayer ACS:180化学发光法测得c-PSA、t-PSA,计算c-PSA/t-PSA值(C/T)。 结果 t-检验比较PCa和BPH组的c-PSA、t-PSA、C/T和Age值,前两者有显著性差异(P<0.01),后两者无显著性差异(P>0.05)。分别计算PCa和BPH组的c-PSA、t-PSA的直线相关系数r,PCa组r=0.981 2, PCa组回归方程为c-PSA=0.935 4×tPSA-2.91, 高度相关。BPH组r=0.410 9。在100%敏感性时,c-PSA 3.75 μg/L、t-PSA 4.0 μg/L、C/T=0.65、c-PSA 7.5 μg/L加(C/T=0.65)的特异性分别为42.3%、38.5%、36.5%、75.0%。 结论 前列腺癌比BPH的c-PSA 和t-PSA相关度高。在保持灵敏度100%时,若结合c-PSA 7.5 μg/L加(C/T=0.65)指标,将明显提高特异性到75.0% 。
Abstract:
Objective    To evaluate complexed prostate-specific antigen (c-PSA) in differential diagnosis of prostate cancer and benign prostate hyperplasia (BPH).     Methods    Totally 60 men were subjected, including 18 cases of prostate cancer (PCa), 27 cases of BPH, and 25 normal individuals (control group). All subjects were diagnosed by ultrasonography and pathological methods. Serum c-PSA and total-PSA (t-PSA) were measured by automated chemiluminescence system Bayer ACS:180. The ratio of c-PSA to t-PSA (C/T) was calculated respectively.     Results    Student t test indicated that significant difference was seen in c-PSA and t-PSA between BPH and PCa, but no difference in C/T and age. There was significant close correlation of c-PSA and t-PSA in PCa group. But no relation of these indexes was seen in BPH group. As for 100% sensitivity, the specificity for c-PSA 3.75 μg/L, t-PSA 4.0 μg/L, C/T=0.65, c-PSA 7.5 μg/L+(C/T=0.65) were 42.3%, 38.5%, 36.5% and 75.0% respectively.      Conclusion    c-PSA and t-PSA have higher relativity in Pca group than in BPH group. As for the sensitivity 100%, it can be apparently improve to 75.0% when c-PSA 7.5 μg/L and C/T radio=0.6 5 are integrated.

参考文献/References:

胡望平,冯福英,叶桂云,等.  血清c-PSA及 C/T在提高前列腺癌诊断特异性中的探讨[J].第三军医大学学报,2007,29(18):1815-1817.

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更新日期/Last Update: 2008-07-16