[1]曾志华,曾明慧,冯雯琪,等.电针阻断胰岛素抵抗及过氧化反应治疗非酒精性脂肪肝的实验研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(11):1055-1057.
 ZENG Zhi-hua,ZENG Ming-hui,FENG Wen-qi,et al.Electroacupuncture treats rat non-alcoholic fatty liver by blocking insulin resistance and peroxidation[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(11):1055-1057.
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电针阻断胰岛素抵抗及过氧化反应治疗非酒精性脂肪肝的实验研究(/HTML )
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第11期
页码:
1055-1057
栏目:
论著
出版日期:
2008-06-15

文章信息/Info

Title:
Electroacupuncture treats rat non-alcoholic fatty liver by blocking insulin resistance and peroxidation
作者:
曾志华曾明慧冯雯琪卓廉士
重庆医科大学:中医药学院,附属第一医院口腔正畸科
Author(s):
ZENG Zhi-hua ZENG Ming-hui FENG Wen-qi ZHUO Lian-shi
School of Traditional Chinese Medicine,Department of Orthodontics, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400050, China
关键词:
非酒精性脂肪肝胰岛素抵抗氧化抗氧化针灸治疗
Keywords:
non-alcoholic fatty liver disease insulin resistance oxidation antioxidationacupuncture
分类号:
R-332; R246; R575.505
文献标志码:
A
摘要:
目的  探讨电针阻断胰岛素抵抗及过氧化反应治疗非酒精性脂肪肝(non-alcoholic fatty liver disease, NAFLD)的机制。  方法  SD大鼠33只按随机抽签法分组:正常对照组(11只),造模组(22只)。正常组以普通饲料喂养,造模组以高脂饲料喂养,8周后处死3只(正常对照组1只,造模组2只),验证造模成功后将造模组分为NAFLD模型组(10只)和电针治疗组(10只),后者施以电针治疗。12周末处死所有大鼠检测血糖(FBG)、血清胰岛素(FINS)、血清游离脂肪酸(FFA)、肝内丙二醛(MDA)、超氧化物歧化酶(SOD)、甘油三酯(TG)、总胆固醇(TC)、谷胱甘肽(GSH)含量变化及肝组织病理学。  结果  与模型组比较,电针组FBG、FINS、FFA降低(P<0.05);肝内MDA、TG、TC显著下降(P<0.01);SOD、GSH活性升高(P<0.01),肝组织脂肪变性和炎性损伤得以改善。  结论  电针通过阻止胰岛素抵抗和过氧化反应之间的恶性循环治疗NAFLD。
Abstract:
Objective    To investigate the mechanism of electroacupuncture in the treatment of non-alcoholic fatty liver disease (NAFLD) .     Methods    Thirty-three male SD rats were randomized into 2 groups: normal control group (n=11,fed with normal food) and experimental rats (n=23, fed with high-fat food). Eight weeks later, 3 rats were randomly selected from the 2 groups respectively and killed to undergo pathological examination of the liver. When the establishment of experimental rats was confirmed, the remaining 20 experimental rats were divided into 2 equal subgroups: NAFLD group (fed continuously with high-fat food) and electroacupuncture treatment group (fed continuously with high-fat food and received the treatment 15 min per day, once a day for 4 weeks). Then all rats were killed to detect the serum levels of fasting blood glucose (FBG), fasting insulin (FINS) and free fatty acids (FFA), liver contents of    malondialdehyde  (MDA),  glycerin tripalmitate    (TG) and total cholesterol (TC), and the activities of liver superoxide dismutase (SOD) and  glutathione   (GSH). Liver pathological changes was examined.     Results    Compared with NAFLD group, electroacupuncture reduced the serum levels of FBG, FINS and FFA (P<0.05), the liver contents of MDA, TG and TC (P<0.01), and increased the activities of SOD and GSH (P<0.01). It also attenuated the liver fatty degeneration and inflammatory injury.     Conclusion    Electroacupuncture can treat NAFLD by blocking the vicious circle of insulin resistance and perooxidation.

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更新日期/Last Update: 2008-06-06