[1]刘中禄,毕玉田,袁军.白藜芦醇减轻三氧化二砷所致大鼠过氧化毒性作用[J].陆军军医大学学报(原第三军医大学学报),2008,30(18):1690-1692.
 LIU Zhong-lu,BI Yu-tian,YUAN Jun.Resveratrol protects against peroxide toxicity in rats induced by arsenic trioxide[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(18):1690-1692.
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白藜芦醇减轻三氧化二砷所致大鼠过氧化毒性作用(/HTML )
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第18期
页码:
1690-1692
栏目:
论著
出版日期:
2008-09-24

文章信息/Info

Title:
Resveratrol protects against peroxide toxicity in rats induced by arsenic trioxide
作者:
刘中禄毕玉田袁军
第三军医大学大坪医院野战外科研究所:实验动物中心,呼吸内科
Author(s):
LIU Zhong-lu BI Yu-tian YUAN Jun
Laboratory Animal Center,Department of Respiratory Diseases, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
关键词:
三氧化二砷白藜芦醇自由基
Keywords:
arsenic trioxide resveratrol free radicals
分类号:
R595.05;R979.3;R995
文献标志码:
A
摘要:
目的    探讨白藜芦醇(resveratrol, RES)减轻三氧化二砷对大鼠的毒性作用。    方法    腹腔注射三氧化二砷连续4周,治疗组在注射三氧化二砷前给予 RES 30、60、120 mg·kg-1·d-1。4周后取动物血清、肝、肺、脾及脑组织测定超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)、NO含量。    结果    与正常对照组相比,三氧化二砷引起动物血清、肝、肺、脾及脑组织NO和MDA水平显著增高,SOD和GSH-Px含量明显下降。RES治疗后显著改善三氧化二砷引起的上述变化,血清和肝、肺、脾及脑组织MDA、NO含量降低,而且总SOD、GSH-Px的活力均有明显升高,RES的作用呈剂量依赖性。    结论    RES可保护抗过氧化酶活性和抑制过氧化物产生。
Abstract:
Objective    To study the effects of resveratrol against toxicity induced by arsenic trioxide in rats.     Methods    Arsenic trioxide was given to SD rats intraperitoneally for 4 weeks. Resveratrol was injected intraperitoneally to the animals 4 h before arsenic trioxide challenge at dose of 30, 60, or 120 mg·kg-1·d-1. Four weeks later, the contents of malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO), glutathione peroxidase (GSH-Px) in serum, lung, spleen, liver and brain tissues were measured.     Results    Compared with the normal control rats, arsenic trioxide challenge resulted in  increases of NO and MDA contents in serum, lung, spleen, liver and brain tissues, and decreases of GSH-Px and SOD levels in the rats received arsenic trioxide only. Resveratrol significantly inhibited these changes induced by arsenic trioxide in rat serum, lung, spleen, liver and brain tissues in a dose-dependent manner.     Conclusion    Resveratrol can protect antiperoxidase activity and inhibit peroxide productions.

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更新日期/Last Update: 2008-09-11