[1]艾智华,房殿春,张忠辉.脂联素基因Gly15Gly多态性与糖尿病大血管病变的关系[J].陆军军医大学学报(原第三军医大学学报),2008,30(06):536-538.
 AI Zhi-hua,FANG Dian-chun,ZHANG Zhong-hui.Association of adiponectin gene Gly15Gly polymorphism with primary macroangiopathy in diabetes mellitus[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(06):536-538.
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第06期
页码:
536-538
栏目:
论著
出版日期:
2008-03-30

文章信息/Info

Title:
Association of adiponectin gene Gly15Gly polymorphism with primary macroangiopathy in diabetes mellitus
文章编号:
1000-5404(2008)06-0536-03
作者:
艾智华房殿春张忠辉
第三军医大学西南医院全军消化病研究所;第三军医大学西南医院内分泌科
Author(s):
AI Zhi-hua FANG Dian-chun ZHANG Zhong-hui

Gastroenterology

Research Center, Department of Endocrinology, Southwest Hospital, Third Military Medical University

关键词:
脂联素基因多态性糖尿病大血管病变
Keywords:
adiponectin gene polymorphism diabetes mellitus macroangiopathy
分类号:
R341;R394.3;R587.2
文献标志码:
A
摘要:
摘要: 目的 探讨脂联素基因Gly15Gly多态性与糖尿病早期大血管病变发生的关系。 方法 运用多聚酶链式反应-限制性片段长度基因多态性(PCR-RFLP法)分析方法,对56例伴大血管病变和120例无大血管病变的2型糖尿病患者脂联素基因Gly15Gly多态性位点进行基因分型。 结果 大血管病变组GG基因型频率(25.0%)显著高于无血管病变组(6.2%),G等位基因频率显著升高(P<0.05);GG基因型血浆脂联素水平显著低于TT和TG基因型。 结论 脂联素基因Gly15Gly多态性与糖尿病大血管并发症的发生有关,脂联素基因+45位点GG基因型是2型糖尿病大血管并发症的易感基因型。
Abstract:
Abstract:  Objective To investigate the association  adiponectin gene polymorphism with primary macroangiopathy in diabetes mellitus.  Methods Type 2 diabetes mellitus (T2DM) patients were included, 56 patients complicated with atherosclerosis (AS) and 120 non-AS group. We evaluated their Gly15Gly polymorphism of adiponectin gene by PCR restriction fragment length polymorphism (PCR-RFLP).  Results The AS patients were more likely to have GG genotype than the non-AS patients (25.0% vs 6.2%, P<0.05). Blood adiponectin in the patients with GG genotype was lower than that in ones with TT or TG genotype [(15.10±7.04) g/ml vs (19.64±6.64) g/ml and (18.38±7.49) g/ml].  Conclusion Gly15Gly polymorphism of adiponectin gene is related to primary macrovascular complications in T2DM. GG genotype is probably the predisposing gene for primary macrovascular complications in T2DM.

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更新日期/Last Update: 2008-04-08