[1]艾智华,房殿春,张忠辉.过氧化物酶体增殖体激活受体-γ2基因Pro12Ala多态性与肥胖的关系[J].陆军军医大学学报(原第三军医大学学报),2008,30(08):691-693.
 AI Zhi-hua,FANG Dian-chun,ZHANG Zhong-hui.Association of Pro12Ala mutation in peroxisome proliferatoractivated receptor-γ2 with obesity in Chinese population[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(08):691-693.
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过氧化物酶体增殖体激活受体-γ2基因Pro12Ala多态性与肥胖的关系(/HTML )
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第08期
页码:
691-693
栏目:
论著
出版日期:
2008-04-30

文章信息/Info

Title:
Association of Pro12Ala mutation in peroxisome proliferatoractivated receptor-γ2 with obesity in Chinese population
作者:
艾智华房殿春张忠辉
第三军医大学西南医院:全军消化病研究所,内分泌科
Author(s):
AI Zhi-hua FANG Dian-chun ZHANG Zhong-hui
Gastroenterology Research Center, Department of Endocrinology, Southwest Hospital, Third Military Medical University
关键词:
过氧化物酶体增殖体激活受体-γ2 (PPAR-γ2)基因多态性肥胖
Keywords:
peroxisome proliferator-activated receptor gene mutation obesity
分类号:
R181.33;R394.1;R589.2
文献标志码:
A
摘要:
目的 探讨过氧化物酶体增殖体激活受体-γ2(PPAR-γ2)基因外显子2的Pro12Ala多态性与肥胖的关系。 方法 运用多聚酶链式反应-限制性片段长度基因多态性(PCR-RFLP法)分析方法,对116例超重或肥胖患者和89例正常对照者PPAR-γ2基因Pro12Ala多态性位点进行基因分型。 结果 超重或肥胖组Ala等位基因频率(11.64%)显著高于正常对照组(5.06%),在所检测人群中,PA/AA基因型者具有更高的体质量指数和血浆甘油三酯水平(P<0.05)。 结论 PPARγ2的Pro12Ala变异与肥胖的发生有关,12Ala更易发生肥胖。
Abstract:
Objective To investigate the polymorphism of peroxisome proliferator-activated receptors-γ2 (PPAR-γ2) and its association with obesity in Chinese population.  Methods According to BMI, 89 subjects who are in normal body weight range and 116 overweighted and obese subjects were included in this study. Their Pro12Ala mutation in the PPAR-γ2 gene was detected by PCR restriction fragment length polymorphism.  Results Allele frequency of Ala mutation of PPAR-γ2 in overweighted and obese subjects (qA=11.64%) was significantly higher than that of normal body weight group (qA=5.06%, P<0.05). Both in overweighted and obese subjects and normal body weight subjects, these with genotype of PA (AA) had higher body mass index and plasma TG than those with the genotype of PP (P<0.05).  Conclusion Pro12Ala mutation in PPAR-γ2 is associated with obesity. The people with the genotype of 12Ala are likely to be obese.

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更新日期/Last Update: 2008-04-28