[1]谢斌,唐春,吴刚,等.c-Met、MMP-2、MMP-9在肝细胞癌中的表达及临床意义[J].第三军医大学学报,2008,30(12):1140-1143.
 XIE Bin,TANG Chun,WU Gang,et al.Expressions and clinical significances of c-Met, MMP-2, MMP-9 in metastasis of human hepatocellular carcinoma: report of 47 cases[J].J Third Mil Med Univ,2008,30(12):1140-1143.
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c-Met、MMP-2、MMP-9在肝细胞癌中的表达及临床意义(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第12期
页码:
1140-1143
栏目:
论著
出版日期:
2008-06-30

文章信息/Info

Title:
Expressions and clinical significances of c-Met, MMP-2, MMP-9 in metastasis of human hepatocellular carcinoma: report of 47 cases
作者:
谢斌唐春吴刚陈平
第三军医大学大坪医院野战外科研究所肝胆外科
Author(s):
XIE Bin TANG Chun WU Gang CHEN Ping
Department of Hepatobiliary Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
关键词:
肝细胞癌  c-Met  MMP-2 MMP-9 转移
Keywords:
hepatocellular carcinoma c-Met matrix metalloproteinase-2 matrix metalloproteinase-9 metastasis
分类号:
R394.2;R730.23;R735.7
文献标志码:
A
摘要:
目的 研究c-Met、基质金属蛋白酶-2(matrix metalloproteinase-2, MMP-2)、基质金属蛋白酶-9(matrix metalloproteinase-9, MMP-9)在肝细胞癌(hepatocellular carcinoma, HCC)中的表达,探讨三者的表达与肝癌侵袭转移间的关系,并初步明确在肝细胞癌预后判断中的作用。 方法  采用免疫组化对47例肝细胞癌手术切除标本中c-Met、MMP-2、MMP-9的表达进行检测,评估c-Met的表达与HCC临床病理因素的关系及与MMP-2、MMP-9表达的关系。 结果  c-Met、MMP-2、MMP-9在肝细胞癌组织中的阳性表达率分别为38.3%、72.3%、89.4%,与正常肝组织比较差异有统计学意义(分别为12%、16%、12%,P<0.05);c-Met阳性表达率与肝细胞癌的转移、淋巴浸润、包膜形成以及肿瘤分化有关(P<0.05),而与性别、年龄、肿瘤的大小、分期无关;MMP-2的阳性表达率仅与肝细胞癌的包膜形成有关(P=0.028);MMP-9的阳性表达率与HCC的各项临床病理因素无关; c-Met阳性表达与MMP-2的异常表达有关(P<0.001)。 结论  在HCC的转移中, HGF/c-Met与HCC的转移有关,并且与MMP系统之间存在联系,可能影响MMP-2、MMP-9的表达,对于HCC的转移防治及预后具有一定的临床意义。
Abstract:
Objective    To investigate the expressions of c-Met, MMP-2, MMP-9 in the invasion, metastasis and prognosis of hepatocellular carcinoma(HCC).     Methods    We used immunohistochemistry to evaluate the expressions of c-Met, MMP-2, and MMP-9, and statistically analyzed the relationship between these expressions and clinicopathological prognostic parameters in 47 patients with HCC. Another 25 samples taken 3 cm away from the margin of tumor mass served as control.      Results    The results showed that the positive rates of the expression of c-Met, MMP-2, MMP-9 in HCC tissue samples were 38.3%, 72.3% and 89.4% respectively, but in normal liver tissue were 12%, 16% and 12% respectively. The expression of c-Met was significantly higher in HCC than in normal liver tissue, while the expressions of MMP-2 and MMP-9 were significantly higher in HCC than in normal liver tissue. c-Met expression was correlated with lymph node status, capsule, metastasis (intra- or extra-hepatic metastasis) and histological grade, but not with gender, age, tumor size, and stage of the disease, similarly MMP-2, MMP-9 expressions were correlated with capsule, but not with gender, age, tumor size, lymph node status, neoplasm stage and histological grade. A statistical significant correlation was found between c-Met and abnormal MMP-2 expression (P<0.01).      Conclusion    These results suggest that c-Met may be involved in the up-regulation of MMP-2, via interaction of HGF/c-Met signal pathway and MMPs, which may plays an important role in the invasion, metastasis and prognosis of HCC.

参考文献/References:

谢斌,唐春,吴刚,等. c-Met、MMP-2、MMP-9在肝细胞癌中的表达及临床意义[J].第三军医大学学报,2008,30(12):1140-1143.

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更新日期/Last Update: 2008-06-13