[1]来小丹,刘松青,黄华,等.氟比洛芬口腔崩解片的制备及质量控制[J].陆军军医大学学报(原第三军医大学学报),2008,30(09):837-839.
　LAI Xiao-dan,LIU Song-qing,HUANG Hua,et al.Preparation and quality control of flurbiprofen orally disintegrating tablets[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(09):837-839.
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第09期
页码:
837-839
栏目:
论著
出版日期:
2008-05-15

文章信息/Info

Title:
Preparation and quality control of flurbiprofen orally disintegrating tablets
作者:
来小丹; 刘松青; 黄华; 林彩; 贺红军
第三军医大学西南医院药学部; 重庆医科大学药学院药剂学教研室
Author(s):
LAI Xiao-dan; LIU Song-qing; HUANG Hua; LIN Cai; HE Hong-jun
Department of Pharmacy, Southwest Hospital, Third Military Medical University; Department of Pharmacy, Pharmacy College, Chongqing Medical University
关键词:
氟比洛芬; 口腔崩解片; HPLC; 含量测定
Keywords:
flurbiprofen;  orally disintegrating table;  high-phase liquid chromatography;  content determination
分类号:
R927.11; R943; R971.1
文献标志码:
A
摘要:
目的  制备氟比洛芬口腔崩解片并建立其质量控制方法。   方法  采用湿法制粒压片法制备口腔崩解片，运用高效液相色谱法（HPLC法）测定其含量。   结果  制备的氟比洛芬口腔崩解片外观完整光洁，硬度为2 kg，崩解时间小于30 s；含量测定线性范围为1.0～10.0 μg/ml，r=0.999 9，平均回收率为99.32%，RSD=1.09%。   结论  本制备法与质量控制方法简便、可行。
Abstract:
Objective  To prepare the flurbiprofen orally disintegrating tablets and establish the procedures of controlling the quality.   Methods  Flurbiprofen orally disintegrating tablets was prepared by wet granulation and it content was determined by HPLC.   Results  The obtained tablets were fine in the shape and smooth in the surface. Their hardness was 2 kg, the disintegrating time was about 30 s. The linear correlation was in a range of 1.0-10.0  μg/ml, r=0.999 9. The average recovery was 99.32%, RSD=1.09% (n=7).   Conclusion  Our methods of flurbiprofen orally disintegrating tablets are simple and feasible in preparation and quality control.

相似文献/References:

[1]蔡双霜,黄华,陈莉,等.固态溶液技术制备辛伐他汀口腔崩解片[J].陆军军医大学学报(原第三军医大学学报),2008,30(11):1102.
[2]来小丹,刘松青,陈勇川,等.氟比洛芬口崩片在健康家兔体内的药代动力学研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(22):2243.
　LAI Xiao-dan,LIU Song-qing,CHEN Yong-chuan,et al.Pharmacokinetics of flurbiprofen orally disintegrating tablets in healthy rabbits[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(09):2243.

更新日期/Last Update: 2008-05-07