[1]张海娜,高原,吴绮楠,等.替米沙坦对糖尿病大鼠认知功能及大脑皮质Ghrelin受体表达的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(14):1342-1345.
 ZHANG Hai-na,GAO Yuan,WU Qi-nan,et al.Effects of telmisartan on cognition and GHSR expression in frontal cortex of diabetic rats[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(14):1342-1345.
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替米沙坦对糖尿病大鼠认知功能及大脑皮质Ghrelin受体表达的影响(/HTML )
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第14期
页码:
1342-1345
栏目:
论著
出版日期:
2008-07-30

文章信息/Info

Title:
Effects of telmisartan on cognition and GHSR expression in frontal cortex of diabetic rats
作者:
张海娜高原吴绮楠肖谦
重庆医科大学附属第一医院老年科;第三军医大学西南医院内分泌科
Author(s):
ZHANG Hai-na GAO Yuan WU Qi-nan XIAO Qian
Department of Gerontology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016; Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
关键词:
替米沙坦糖尿病GHSR认知功能
Keywords:
telmisartan diabetes growth hormone secretagogues receptorcognitive ability
分类号:
R587.1;R749.24;R972.4
文献标志码:
A
摘要:
目的  观察替米沙坦对糖尿病大鼠认知功能和大脑皮质Ghrelin受体GHSR的表达影响。 方法  将40只大鼠分为正常对照组、糖尿病组、替米沙坦组。建立STZ糖尿病大鼠模型,替米沙坦干预12周,Morris水迷宫测试其认知能力。RT-PCR检测大脑皮质GHSR mRNA水平表达变化,免疫组化观察大鼠大脑皮质GHSR蛋白的表达。 结果  替米沙坦组与糖尿病组比较,Morris水迷宫测试中潜伏期明显缩短(P<0.05),中心区停留时间百分比和通过原平台位置次数增加(P<0.05),免疫组化显示GHSR蛋白表达增加(P<0.05),RT-PCR显示GHSR在mRNA水平表达增加(P<0.05)。 结论  糖尿病引起大鼠认知功能下降和GHSR表达下降,GHSR下降可能与认知障碍有关。早期替米沙坦治疗可使糖尿病大鼠认知功能和海马GHSR表达接近正常。
Abstract:
Objective    To observe the effects of telmisartan on cogtive function and the expression of Ghrelin receptors, growth hormone secretagogues receptor(GHSR) in diabetic rats.     Methods    Forty rats were randomly divided into 3 groups: control group, diabetic model group, and telmisartan treatment group. Streptozotocin-induced diabetic rat model(65 mg/kg,ip) was established.  In the telmisartan treatment group, the rats were treated with telmisartan (13.3 mg·kg-1·d-1) for 12 weeks. Learning and memory abilities of the rats were tested by the Morris water maze. The  mRNA and protein levels of GHSR in frontal cortex were detected by RT-PCR and immunohistochemistry.     Results    Compared with the diabetic model group, the telmisartan treatment group showed a significant decrease in the mean time of escape latencies(P<0.05)and an increased percentage of time spent in the central area and the more times navigating the original platform position(P<0.05). The mRNA and protein expressions of GHSR were elevated significantly in frontal cortex(P<0.05).     Conclusion    The cognitive dysfunctions induced by diabetes may be correlated with the decrease of GHSR and can be alleviated with telmisartan.

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更新日期/Last Update: 2008-07-21