[1]陈勇鹏,王贵学,陈琰,等.地塞米松血管内支架的涂层制备及体外缓释实验研究[J].第三军医大学学报,2008,30(10):935-937.
 CHEN Yong-peng,WANG Gui-xue,CHEN Yan,et al.Coating for dexamethasone-eluting intravascular stent and its drug sustained release in vitro[J].J Third Mil Med Univ,2008,30(10):935-937.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第10期
页码:
935-937
栏目:
论著
出版日期:
2008-05-30

文章信息/Info

Title:
Coating for dexamethasone-eluting intravascular stent and its drug sustained release in vitro
作者:
陈勇鹏王贵学陈琰晋献春侯延斌罗来龙孙大贵
第三军医大学新桥医院:中医科,全军呼吸内科研究所,全军呼吸病研究重点实验室;重庆大学:生物工程学院,化学化工学院
Author(s):
CHEN Yong-peng WANG Gui-xue CHEN Yan JIN Xian-chun HOU Yan-bin LUO Lai-long SUN Da-gui
Department of Traditional Chinese Medicine, Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University; College of Bioengineering, College of Chemistry and Chemical Engineering, Chongqing University
关键词:
地塞米松支架体外研究缓释
Keywords:
dexamethasone stents in vitro sustained release
分类号:
R944.9;R969;R977.11
文献标志码:
A
摘要:
目的  制备地塞米松血管内支架的涂层,观察体外缓释特性。  方法  采用喷涂、浸涂两种方法制备支架,以高效液相色谱仪检测载药量,并进行体外药物缓释测定。  结果  喷涂支架的载药量为(24.26±5.23) μg,浸涂4 d的载药量为(93.15±7.83) μg。浸涂4 d的支架,药物缓慢释放,15 d时释放84%。  结论  制备的支架具有明显的缓释作用。
Abstract:
Objective  To prepare the coating of dexamethasone-eluting intravascular stent and observe the features of its delayed release in vitro.   Methods  Spray painting and dipping coating were used respectively to prepare stent coating, and then high performance liquid chromatography (HPLC) was used to detect the drug loading. The stents prepared by dipping coating were set in a flow of 50 ml PBS buffer at a velocity of 20 ml/min, and 0.5 ml buffer was collected at 6 h and 1, 2, 4, 6, 8, 10, 12, 15 d respectively with another 0.5 ml fresh PBS being added immediately. The drug content of the 0.5 ml buffer was detected by HPLC for drug sustained release in vitro.   Results  The drug loading of stents prepared by spray painting was (24.26±5.23) μg, while that stents prepared by dipping coating for 4 d was (93.15±7.83) μg. Drugs were released slowly and the release rate reached 84% at 15 d.    Conclusion  The dipping coating-prepared stents have evident effect of sustained release.

参考文献/References:

陈勇鹏,王贵学,陈琰,等. 地塞米松血管内支架的涂层制备及体外缓释实验研究[J]. 第三军医大学学报,2008,30(10):935-937.

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更新日期/Last Update: 2008-05-26