[1]王顺和.脱髓鞘病变中轴突损伤的实验研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(05):386-389.
　WANG Shun-he.Axonal damage of demyelination disease in mice[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(05):386-389.
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脱髓鞘病变中轴突损伤的实验研究(/HTML )
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第05期
页码:
386-389
栏目:
论著
出版日期:
2008-03-15

文章信息/Info

Title:
Axonal damage of demyelination disease in mice
作者:
王顺和
重庆医科大学基础医学院病理学教研室
Author(s):
WANG Shun-he
Department of Pathology, College of Basic Medical Sciences, Chongqing Medical University
关键词:
实验性变态反应性脑脊髓炎; 多发性硬化; 脱髓鞘病变; 轴突损伤
Keywords:
experimental autoimmune encephalomyelitis;  multiple sclerosis;  demyelination;  axonal damage
分类号:
R-33; R741.02; R744.5
文献标志码:
A
摘要:
目的 探讨多发性硬化等脱髓鞘疾病中轴突的损伤以及轴突损伤出现的时间、形态特征。 方法 用MOG35-55蛋白多肽免疫C57BL/6J小鼠复制多发性硬化的动物模型，结合常规形态学染色和神经系统特殊染色，在疾病发作前期、疾病发作期、高峰期和慢性期不同时间点观察炎症反应、髓鞘脱失和轴突的变化。 结果 髓鞘的脱失和轴突的损伤出现在疾病的发作前期，并且这种改变与炎症细胞浸润及髓鞘脱失有密切的关系。损伤的轴突在形态上表现为不规则、肿胀、直径不一致、扭曲；轴突断裂，在断端呈球状、卵圆形或橄榄状；另一种突出的变化是轴突消失。 结论 脱髓鞘病变中轴突的损伤是一种早期的和普遍的病变，且轴突的损伤与多种因素有关。
Abstract:
Objective To explore the axonal damages in demyelination disease and its time window and morphological features of damaged axons.  Methods Mouse model of multiple sclerosis (MS) was prepared by immunizing C57BL/6J mice with myelin oligodendrocyte glycoprotein peptides35-55 (MOG 35-55) to induce experimental autoimmune encephalomyelitis (EAE). Inflammation, demyelination and axonal damage at different time points of EAE including preonset, onset, peak and chronic were observed by common histology and specific stainings for the central nervous system.  Results Demyelination and axonal damage occurred at the early stage of EAE, and was strongly related to inflammatory cell infiltration and demyelination of the central nervous system. Damaged axons showed the typical morphological features, including axon distortion, swelling, irregular diameter, axon transection with the ends ovoid, or bulb, and even axon disappearance.  Conclusion Axonal damage is an early and common event in demyelination disease, and many factors might contribute to axonal damage.

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更新日期/Last Update: 2008-04-21