[1]彭丹丹,李志梁.冠状动脉粥样硬化性心脏病患者单核细胞CX3CR1表达的研究[J].第三军医大学学报,2008,30(06):546-548.
 PENG Dan-dan,LI Zhi-liang.CX3CR1 expressions in monocytes from patients with coronary heart diseases[J].J Third Mil Med Univ,2008,30(06):546-548.
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冠状动脉粥样硬化性心脏病患者单核细胞CX3CR1表达的研究(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第06期
页码:
546-548
栏目:
论著
出版日期:
2008-03-30

文章信息/Info

Title:
CX3CR1 expressions in monocytes from patients with coronary heart diseases
文章编号:
1000-5404(2008)06-0546-03
作者:
彭丹丹李志梁
南方医科大学珠江医院心血管内科
Author(s):
PENG Dan-dan LI Zhi-liang
Department of Cardiology, Zhujiang Hospital, Southern Medical University
关键词:
冠心病CX3CR1表达动脉粥样硬化冠状动脉病变
Keywords:
coronary heart disease CX3CR1 expression atherosclerosis coronary lesion
分类号:
R329.33;R446.11;R541.402
文献标志码:
A
摘要:
目的 观察CX3CR1在不同类型冠状动脉粥样硬化性心脏病(简称冠心病)患者外周血单核细胞中的表达。 方法 选择经冠状动脉造影后确诊为冠心病的患者,其中54例稳定型心绞痛病例及61例急性冠脉综合征的病例作为研究对象;以冠状动脉造影正常的20例患者作为正常对照组,24例冠状动脉造影正常但有胸前区疼痛的病例作为阳性对照。利用流式细胞仪直接免疫荧光法检测不同类型患者外周血单核细胞上CX3CR1的表达;同时采用Gensini评分系统对冠心病患者冠状动脉病变程度进行定量评分,并分析CX3CR1与Gensini积分间的关系。  结果 冠心病患者CX3CR1表达水平高于正常对照组[正常对照组为(0.46±0.27)%、稳定性心绞痛组为(12.59±6.05)、急性冠脉综合征组为 (38.77±13.22),P<0.01],急性冠脉综合征患者CX3CR1表达明显高于稳定型心绞痛患者,差异有统计学意义(P<0.01);且冠心病患者CX3CR1表达水平与Gensini积分呈显著正相关(r=0.913, P<0.01)。  结论 冠心病患者CX3CR1表达水平明显升高,并且其增加程度与冠脉的狭窄程度有相关性。
Abstract:
Objective To explore the changes of CX3CR1 expressions in monocytes from the patients with different types of coronary heart diseases (CHD).  Methods The expressions of CX3CR1 in monocytes were measured by direct immunofluorescence associated with flow cytometry (FCM) in 54 patients with stable angina pectoris (SAP) confirmed by coronary arteriography, 61 patients with acute coronary syndrome (ACS), 20 normal individuals and 24 patients with chest pain syndrome (CPS). Gensini score system was utilized to quantitatively assess the coronary lesion in CHD patients. Finally, the correlation of CX3CR1 levels and Gensini scores was analyzed.  Results CX3CR1 expressions in monocytes from the CHD patients were markedly higher than those in normal individuals (P<0.01). CX3CR1 expressions in monocytes from the ASC patients were significantly higher than those in the SAP patients (P<0.01). CX3CR1 expressions in monocytes from the CHD patients was positively related to Gensini scores (r=0.913, P<0.01).  Conclusion The CHD patients have higher CX3CR1 expressions. The increased degree of CX3CR1expressions is related to the severity of CHD.

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更新日期/Last Update: 2008-04-08