[1]向平,宋银子,陈沅,等.提高大鼠心肌梗死模型成功率及存活率的研究[J].第三军医大学学报,2008,30(04):329-332.
 XIANG Ping,SONG Yin-zi,CHEN Yuan,et al.Methods on enhancing success rate and survival rate of rat model of myocardial infarction[J].J Third Mil Med Univ,2008,30(04):329-332.
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提高大鼠心肌梗死模型成功率及存活率的研究(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第04期
页码:
329-332
栏目:
论著
出版日期:
2008-02-28

文章信息/Info

Title:
Methods on enhancing success rate and survival rate of rat model of myocardial infarction
作者:
向平宋银子陈沅涂柳朱高慧
重庆医科大学:儿童医院心血管内科,基础医学院生理学教研室;香港中文大学儿科系
Author(s):
XIANG Ping SONG Yin-zi CHEN Yuan TU Liu ZHU Gao-hui
Department of Cardiology, Children’s Hospital, Department of Physiology, Chongqing Medical University; Department of Pediatrics, The Chinese University of Hong Kong
关键词:
冠脉结扎心肌梗死利多卡因成功率
Keywords:
coronary artery ligation myocardial infraction lidocaine success rate
分类号:
R-332;R542.22;R971.2
文献标志码:
A
摘要:
目的 探讨结扎位置、冠状静脉变异等因素对大鼠心肌梗死(myocardial infarction, MI)模型建立的成功率以及利多卡因的使用对模型的死亡率的影响。  方法 120只雄性SD大鼠按随机排列表法分为4组:低位结扎且冠状静脉不明显组(30只)、低位结扎且冠状静脉明显组(30只)、高位结扎组(30只)以及高位结扎且使用利多卡因组(30只),计算建模后各组死亡率,测定各组心功能及梗死面积。  结果 结扎位置较高时模型成功率为93.0%,而结扎位置较低时的成功率为67.3%;高位结扎不加利多卡因大鼠死亡率为43.3%,加用利多卡因后大鼠死亡率则降为13.3%。  结论 高位结扎时能明显提高模型成功率,加用利多卡因后死亡率明显下降。
Abstract:
Objective To investigate the effects of different ligation position, vena coronaria variation and lidocaine on myocardial infarction size and mortality in rats.   Methods Totally 120 male SD rats were divided into four groups with 30 rats in each group: low ligation with invisible vena coronaria, low ligation with visible vena coronaria, high ligation, and high ligation plus lidocaine.   Results MI was successfully created in 93.0% rats of high ligation groups and in 67.3% rats of low ligation groups. The mortality was 43.3% in rats of high ligation groups, only 13.3% in rats when lidocaine in use.   Conclusion High ligation increases the success rate of rat model of myocardial infarction and the application of lidocaine decreases the mortality of the rat model.

参考文献/References:

向平, 宋银子, 陈沅,等. 提高大鼠心肌梗死模型成功率及存活率的研究[J].第三军医大学学报,2008,30(4):329-332.

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更新日期/Last Update: 2008-04-29