[1]刘宏,李敛,余荣杰,等.无功能移植肾切除对群体反应抗体的影响[J].第三军医大学学报,2008,30(10):986-988.
 LIU Hong,LI Lian,YU Rong-jie,et al.Impact of transplant nephrectomy on panel reactive antibodies[J].J Third Mil Med Univ,2008,30(10):986-988.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第10期
页码:
986-988
栏目:
论著
出版日期:
2008-05-30

文章信息/Info

Title:
Impact of transplant nephrectomy on panel reactive antibodies
作者:
刘宏李敛余荣杰赵洪雯吴雄飞
第三军医大学西南医院肾内科
Author(s):
LIU Hong LI Lian YU Rong-jie ZHAO Hong-wen WU Xiong-fei
Department of Kidney, Southwest Hospital, Third Military Medical University
关键词:
肾移植群体反应抗体移植免疫
Keywords:
kidney transplantation panel reactive antibody transplantation immunity
分类号:
R392.1;R617;R699.2
文献标志码:
A
摘要:
目的  观察无功能移植肾切除对肾移植受者群体反应抗体(panel reactive antibody, PRA)及再次肾移植的影响。  方法  收集我院2004-2007年收治的15例移植肾切除患者,分别于肾移植前,移植肾切除前,移植肾切除后1个月、半年、1年检测其PRA水平,同时行移植肾病理检查。部分患者经HLA配型检查后进行再次肾移植。  结果  肾移植后受者PRA高于移植前,移植肾切除后1个月PRA水平进一步升高,在移植后半年及1年后逐渐降低。采用LAT板检查可发现新的HLA致敏位点,肾脏病理检查肾间质有多量C4d沉积。通过HLA配型避开致敏位点选择供肾,7例患者行再次肾移植均获成功。  结论  移植肾切除可导致血清中PRA水平显著升高,PRA检查可发现新的HLA致敏位点,经良好HLA配型不影响再次肾移植。
Abstract:
Objective  To observe the impact of transplant nephrectomy on panel reactive antibodies and a secondary renal transplantation.   Methods  Panel reactive antibodies in 15 patients with a failed renal transplant admitted in our hospital between 2004 to 2007 were measured before transplantation, before and 1 month, 6 months, 12 months after transplant nephrectomy, and the pathological changes were observed after transplant nephrectomy.   Results  Panel reactive antibodies was increasing after renal transplantation, and reached the highest level one month after transplant nephrectomy, then grandually got down. New HLA allosensitization sites were discovered after transplant nephrectomy. Large amount of C4d was stained in failed transplant.   Conclusion  Serum PRA increased after transplant nephrectomy. New HLA allosensitization sites were found, which may be useful in HLA matching.

参考文献/References:

刘宏,李敛,余荣杰,等. 无功能移植肾切除对群体反应抗体的影响[J]. 第三军医大学学报,2008,30(10):986-988.

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更新日期/Last Update: 2008-05-27