[1]吴艳,王毅,曾绍凡,等.老年2型糖尿病瘦素、骨密度变化及相关因素的研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(22):2188-2190.
　WU Yan,WANG Yi,ZENG Shao-fan,et al.Bone density, leptin level and other related factors in elder patients with type 2 diabetes[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(22):2188-2190.
点击复制

老年2型糖尿病瘦素、骨密度变化及相关因素的研究(/HTML )
分享到：

陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第22期
页码:
2188-2190
栏目:
论著
出版日期:
2007-11-30

文章信息/Info

Title:
Bone density, leptin level and other related factors in elder patients with type 2 diabetes
作者:
吴艳; 王毅; 曾绍凡; 杨刚毅; 李仁哲; 谭兴容; 李颖
重庆医科大学：第二附属医院内分泌科,附属北碚医院内分泌科，医学检验系临床生物化学教研室；四川省遂宁市人民医院内分泌科
Author(s):
WU Yan;  WANG Yi;  ZENG Shao-fan;  YANG Gang-yi;  LI Ren-zhe;  TAN Xing-rong;  LI Ying
Chongqing Medical University: Department of Endocrinology, the Second Affiliated Hospital, Chongqing 400010，Department of Endocrinology, Affiliated Beibei Hospital, Chongqing 400700,  Department of Clinical Biochemistry, Faculty of Laboratory Medicine, Chongqing 400010; Department of Endocrinology, Suining People’s Hospital, Suining 629000, China
关键词:
瘦素; 单能定量CT; 骨密度; 糖尿病; 2型
Keywords:
leptin;  quantitative computed tomography;  bone density;  type 2 diabetes mellitus
分类号:
R322.71;R44;R587.1
文献标志码:
A
摘要:
目的  探讨老年2型糖尿病(T2DM)患者骨密度变化及其与瘦素、性激素及各种骨转换因子的相关关系。  方法  采用单能定量CT（QCT）对53例2型糖尿病患者及40 例健康老年人进行脊柱骨密度（BMD）测定，并分析受试者的骨密度与体质量指数（BMI）、腰臀比（WHR）、血清瘦素（leptin）、性激素、骨钙素(BGP)、骨特异性碱性磷酸酶(B-ALP)、抗酒石酸酸性磷酸酶-5b(TRACP-5b)等指标间的关系。  结果  ①T2DM组脊柱BMD均值显著低于对照组(P<0.05)，T2DM组血浆瘦素浓度较对照组显著升高(P<0.05)。②相关性研究显示，T2DM组瘦素水平与L1椎体及脊柱BMD均值呈显著负相关（r=-0.443, r=-0.373, P<0.05）。③多元线性回归分析表明，T2DM组中瘦素、E2、T分别是BMD变化的独立相关因素。  结论  老年2型糖尿病患者存在不同程度的骨密度下降。瘦素是老年T2DM患者骨量减少的影响因素，但不是直接因素。
Abstract:
Objective    To investigate the changes of bone mineral density (BMD) and the relationship of BMD to serum leptin concentrations, body mass index (BMI), waist hip ratio (WHR), estradiol(E2), testosterone(T), biochemical markers of bone turnover as well as other factors in the elderly subjects with Type 2 diabetes mellitus(T2DM).     Methods    BMDs of spine were measured by QCT in patients with T2DM (n=53) and health controls (n=40).The relationship of BMD with serum leptin concentrations, BMI, WHR, E2, T, bone Gla protein, bone alkaline phosphatase, tartrate resistant acid phosphatase 5b levels were also analyzed.     Results    The spine BMD values in the T2DM patients were significantly decreased compared with control (P<0.05) and the serum leptin levels were significantly higher than controls (P<0.05). Serum leptin concentrations was negatively correlated with L1 BMD and spine mean BMD in the T2DM patients (r=-0.443，r=-0.373；both P<0.05). Multiple regression analysis showed that serum leptin concentrations, E2 and T were independent related factors influencing BMD in T2DM .     Conclusion    The spine BMD in elderly T2DM patients is lower than that of control group. Serum leptin does not have a significant direct influence on bone mass in elderly T2DM patients.

相似文献/References:

[1]刘波,吴小翎,张霞,等.福辛普利对非酒精性脂肪性肝炎大鼠肝纤维化的作用[J].陆军军医大学学报(原第三军医大学学报),2012,34(16):1646.
　Liu Bo,Wu Xiaoling,Zhang Xia,et al.Effects and mechanism of fosinopril on hepatic fibrosis in rats with nonalcoholic steatohepatitis[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(22):1646.
[2]刘茜,吴亚梅,徐玲,等.急性缺氧诱导C57BL/6J小鼠瘦素表达增加[J].陆军军医大学学报(原第三军医大学学报),2007,29(13):1311.
　LIU Xi,WU Ya-mei,XU Ling,et al.Influence of hypoxia on leptin expression in C57BL/6J mice[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(22):1311.
[3]高立芳,赵邦霞,谭冬梅,等.瘦素在着床前小鼠胚胎中的表达及其对胚胎发育的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(14):1316.
　GAO Li-fang,ZHAO Bang-xia,TAN Dong-mei,et al.Leptin expression in mouse pre-implantation embryos and its effect on embryo development in vitro[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(22):1316.
[4]刘戈云,何文华,李弼民,等.熊果酸对瘦素诱导的肝星状细胞JAK2-STAT3活化及活性氧产生的影响[J].陆军军医大学学报(原第三军医大学学报),2011,33(19):2016.
　Liu Geyun,He Wenhua,Li Bimin,et al.Effect of ursolic acid on leptin-induced JAK2-STAT3 activation and reactive oxygen species generation in hepatic stellate cells[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(22):2016.
[5]谭兴容,杨刚毅,李伶,等.Exenatide对胰岛素抵抗大鼠胰岛素敏感性及脂联素、瘦素水平的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(20):2201.
　Tan Xingrong,Yang Gangyi,Li Ling,et al.Exenatide improves insulin sensitivity of insulin resistant rats by decreasing plasma adiponectin and increasing leptin levels[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(22):2201.
[6]王丽红,陈锦凤,马红英,等.瘦素对大鼠体外胰岛β细胞胰岛素合成与分泌的抑制作用[J].陆军军医大学学报(原第三军医大学学报),2010,32(08):850.
[7]李素芬,杨鹰.不同浓度瘦素对人胚胎绒毛滋养细胞膜胰岛素受体磷酸化的抑制作用[J].陆军军医大学学报(原第三军医大学学报),2010,32(23):2530.
　Li Sufen,Yang Ying.Inhibitory effect of leptin on phosphorylation of insulin receptors in trophoblast cells[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(22):2530.
[8]满永贤,郑琳琳,郭俊岩.中重度单纯性肥胖症青少年早期动脉粥样硬化相关因素的探讨[J].陆军军医大学学报(原第三军医大学学报),2008,30(17):1679.
[9]张阳,卢永辉,缪洪明,等.肿瘤坏死因子-α拮抗瘦素抑制胰岛素合成及分泌作用的实验观察[J].陆军军医大学学报(原第三军医大学学报),2011,33(06):558.
　Zhang Yang,Lu Yonghui,Miao Hongming,et al.Antagonistic effect of TNF-α on leptin-mediated inhibition of insulin synthesis and secretion in INS-1E cells and rat pancreatic islets[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(22):558.
[10]李俊峰,赵正斌,岳伟,等.维生素C和E对瘦素诱导的肝星状细胞增殖与TIMP-1上调的抑制作用[J].陆军军医大学学报(原第三军医大学学报),2012,34(04):303.
　Li Junfeng,Zhao Zhengbin,Yue Wei,et al.Vitamins C and E suppress leptin-induced proliferation and TIMP-1 upregulation in hepatic stellate cells[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(22):303.

更新日期/Last Update: 2008-07-01