[1]徐广民,陶国才,易斌.异氟烷对大鼠肝脏缺血再灌注损伤时细胞间黏附分子-1表达的影响[J].第三军医大学学报,2008,30(03):241-243.
 XU Guang-min,TAO Guo-cai,YI Bin.Effect of Isoflurane on ICAM-1 expression in rats during liver ischemiareperfusion injury[J].J Third Mil Med Univ,2008,30(03):241-243.
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异氟烷对大鼠肝脏缺血再灌注损伤时细胞间黏附分子-1表达的影响(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第03期
页码:
241-243
栏目:
论著
出版日期:
2008-02-15

文章信息/Info

Title:
Effect of Isoflurane on ICAM-1 expression in rats during liver ischemiareperfusion injury
作者:
徐广民陶国才易斌
第三军医大学西南医院麻醉科
Author(s):
XU Guang-min TAO Guo-cai YI Bin
Department of Anesthesiology, Southwest Hospital, Third Military Medical University
关键词:
异氟烷缺血再灌注损伤细胞间黏附分子-1
Keywords:
Isoflurane ischemia-reperfusion injury intercellular adhesion molecule-1
分类号:
R392.13; R614; R657.3
文献标志码:
A
Abstract:
Objective  To investigate the role of intercellular adhesion molecule-1 (ICAM-1) in Isoflurane against hepatic ischemia-reperfusion (I/R) injury in vivo.   Methods  Thirty-two female SD rats were randomly divided into 4 groups: sham-operation group (A), I/R group (B), Isoflurane group (C), I/R+ Isoflurane group (D). Groups A and C were be used as controls. In groups B and C, the hepatic hilar vessels distributing to the left and median lobes were clamped to induce partial hepatic ischemia (70%). Reperfusion was done 60 min after hepatic ischemia. The animals were killed 3 h after reperfusion, then the specimens of liver tissues and blood were obtained. ALT and AST in blood serum were detected as liver damage markers. The histological examination of liver tissues was done by hematoxylin and eosin staining. The levels of ICAM-1 protein in the hepatic tissues were detected by immunohistochemistry.    Results After hepatic ischemia-reperfusion, the ICAM-1  protein expression in the hepatic tissues increased; ALT and AST increased; Reperfusion induced severe liver damage. Isoflurane significantly inhibited the ICAM-1 expression.   Conclusion The degree of hepatic ischemia-reperfusion injury is closely associated with the expression level of ICAM-1. Isoflurane abates liver ischemia-reperfusion injury and inhibits the ICAM-1 expression.

参考文献/References:

徐广民,陶国才,易斌. 异氟烷对大鼠肝脏缺血再灌注损伤时细胞间黏附分子-1表达的影响[J].第三军医大学学报,2008,30(3):241-243.

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更新日期/Last Update: 2008-05-04