[1]刘力,秦晓霞,黄永进,等.精神分裂症认知功能障碍与事件相关电位P300的相关性研究[J].第三军医大学学报,2007,29(23):2286-2288.
 LIU Li,QIN Xiao-xia,HUANG Yong-jin,et al.Relationship between cognitive disorders in schizophrenia and event-related potential P300[J].J Third Mil Med Univ,2007,29(23):2286-2288.
点击复制

精神分裂症认知功能障碍与事件相关电位P300的相关性研究(/HTML )
分享到:

《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第23期
页码:
2286-2288
栏目:
论著
出版日期:
2007-12-15

文章信息/Info

Title:
Relationship between cognitive disorders in schizophrenia and event-related potential P300
作者:
刘力秦晓霞黄永进毕红希
中国医科大学附属第一医院心理科
Author(s):
LIU Li QIN Xiao-xia HUANG Yong-jin BI Hong-xi
(Department of Psychology, The First Affiliated Hospital of China Medical University
关键词:
精神分裂症认知障碍事件相关电位P300
Keywords:
schizophrenia cognitive disorder eventrelated potentials P300
分类号:
R338.8; R741.02; R749.3
文献标志码:
A
摘要:
目的  探讨首发精神分裂症患者认知障碍与事件相关电位P300之间的相关性。  方法  应用丹麦丹迪公司KeyPointV2.12 诱发电位仪(ERPs),对60例精神分裂症患者、3例急性精神分裂样障碍患者及40例健康人(对照组)使用听觉Oddball范式检测P300成分,同时运用阳性和阴性症状量表(PANSS)对患者组进行精神症状评定,并用主成分分析方法分离出几个症状因子。  结果  PANSS项目主成分分析显示认知障碍、阴性症状、抑郁症状、敌对/兴奋、妄想/幻觉5个因子;与健康对照组相比,P300波幅在Fz、Cz、Pz、T3、T4 5个记录区差异均有显著性(P<0.05,P<0.01),P300潜伏期无显著差异(P>0.05),患者组认知障碍因子仅与Fz、T3处P300波幅呈负相关(r=-0.43, P<0.01; r=-033, P<0.05)。  结论  额及颞区P300波幅降低反映精神分裂症患者一定程度的认知损害。
Abstract:
Objective  To explore the relationship between the cognitive  disorders in the first episode of schizophrenia and P300 components.   Methods  P300 components were measured by using an auditory oddball paradigm  with a Denmark KeyPoint Evoked Potentials instrument in 60 cases of schizophrenia and 3 cases of schizophreniform disorder, whose psychopathological status was assessed with the Positive and Negative Syndrome Scale (PANSS). Forty healthy subjects were used as control.   Results  The principal component analysis of the PANSS items revealed five factors: cognitive disorder, negative symptoms, depressive disorder, hostility/excitement and delusion/hallucination. The patients had lower amplitude of P300 at Fz, Cz, Pz, T3 and T4 than the normal controls (P<0.05 or P<0.01). The scores for the cognitive function were correlated negatively with the amplitude of P300 recorded at Fz and T3, but not with Cz, Pz or T4.   Conclusion  The decreased amplitude of frontotemporal P300 reflects the cognitive disorder in schizophrenia to some extent.

相似文献/References:

[1]张丹,刘莉,欧建君,等.认知矫正治疗对精神分裂症患者认知功能和服药依从性的影响[J].第三军医大学学报,2015,37(16):1682.
[2]程国华,彭超,李永德,等.双环己酮草酰二腙诱导精神分裂症小鼠模型胼胝体有髓神经纤维脱髓鞘的定量观测[J].第三军医大学学报,2013,35(07):598.
 Cheng Guohua,Peng Chao,Li Yongde,et al.Quantitation of demyelination in corpus callosum of CPZ-induced mouse model of schizophrenia[J].J Third Mil Med Univ,2013,35(23):598.
[3]魏涛,黄颖,巩尊科,等.应用洛文斯顿作业疗法评定脑卒中患者认知障碍[J].第三军医大学学报,2011,33(18):1964.
 Wei Tao,Huang Ying,Gong Zunke,et al.Loewenstein occupational therapy in assessment of cognitive disorder in patients with cerebral stroke[J].J Third Mil Med Univ,2011,33(23):1964.
[4]黄平,杨泽云.中药血府逐瘀汤辅助阿立哌唑治疗闭经的精神分裂症对照观察[J].第三军医大学学报,2011,33(06):625.
 Huang Ping,Yang Zeyun.Controlled observation of traditional Chinese medicine Xuefuzhuyu decoction combined with aripiprazole in treatment of schizophrenic patients with antipsychotic-induced amenorrhea[J].J Third Mil Med Univ,2011,33(23):625.
[5]李大奇,苏华龙,吴胜.648例首发精神分裂症用药情况[J].第三军医大学学报,2011,33(06):643.
[6]刘娜,孟品,耿闪,等.缺血性卒中急性期血压水平与卒中后认知障碍的关系[J].第三军医大学学报,2016,38(08):855.
 Liu Na,Meng Pin,Geng Shan,et al.Association between blood pressure in acute phase of ischemic stroke and post-stroke cognitive impairment[J].J Third Mil Med Univ,2016,38(23):855.
[7]郭菁,李雷雷,黄婷,等.米氮平辅助治疗精神分裂症阴性症状疗效与安全性的Meta分析[J].第三军医大学学报,2013,35(18):1984.
 Guo Jing,Li Leilei,Huang Ting,et al.A Meta analysis on efficiency and safety of mirtazapine in treatment of negative symptoms in schizophrenia[J].J Third Mil Med Univ,2013,35(23):1984.
[8]李凤,陈明,李小刚.误诊为精神分裂症的额颞叶痴呆1例[J].第三军医大学学报,2013,35(22):2494.
[9]李永德,王芸,程国华,等.不同双环己酮草酰二腙剂量诱导小鼠行为学改变及海马CA1区和DG区内有髓神经纤维改变[J].第三军医大学学报,2013,35(13):1331.
 Li Yongde,Wang Yun,Cheng Guohua,et al.Different doses of cuprizone induce mice behavior alterations and changes of myelinated nerve fibers in hippocampal CA1 and DG regions[J].J Third Mil Med Univ,2013,35(23):1331.
[10]吴静,邓志宽,赵景宏,等.慢性肾病对患者认知功能的影响及其相关因素的初步研究[J].第三军医大学学报,2016,38(15):1773.
 Wu Jing,Deng Zhikuan,Zhao Jinghong,et al.Impact of chronic kidney disease on patients’ cognitive function and its related factors: a preliminary study[J].J Third Mil Med Univ,2016,38(23):1773.

更新日期/Last Update: 2008-05-23