[1]王祥峰,张连阳,何渝军,等.结直肠癌患者血清及粪便中热休克蛋白60检测的临床意义[J].第三军医大学学报,2007,29(13):1334-1336.
　WANG Xiang-feng,ZHANG Lian-yang,HE Yu-jun,et al.Clinical significance of HSP60 in serum and stool of colorectal cancer patients[J].J Third Mil Med Univ,2007,29(13):1334-1336.
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结直肠癌患者血清及粪便中热休克蛋白60检测的临床意义(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第13期
页码:
1334-1336
栏目:
论著
出版日期:
2007-07-15

文章信息/Info

Title:
Clinical significance of HSP60 in serum and stool of colorectal cancer patients
作者:
王祥峰; 张连阳; 何渝军; 李春穴; 刘宝华; 童卫东
第三军医大学大坪医院野战外科研究所：普通外科, 创伤一科
Author(s):
WANG Xiang-feng;  ZHANG Lian-yang;  HE Yu-jun;  LI Chun-xue;  LIU Bao-hua;  TONG Wei-dong
Department of General Surgery, Trauma Center, Institute of Surgery Research, Daping Hospital, Chongqing 400042, China
关键词:
结直肠癌; HSP60;  血清;  粪便
Keywords:
colorectal cancer;  HSP60;  serum;  stool
分类号:
R341; R730.43; R735.3
文献标志码:
A
摘要:
目的    探讨热休克蛋白（heat shock protein 60，HSP60）在结直肠癌患者血清和粪便中的表达及其对结直肠癌的诊断价值。    方法    采用间接ELISA法，检测40例结直肠癌患者及相应正常对照的血清及粪便中HSP60表达。    结果    HSP60在结直肠癌患者血清及粪便中较正常对照明显增高（P<0.05），且粪便浓度高于血清（P<0.05）;结直肠癌患者粪便中HSP60含量与不同肿瘤浸润期及远处转移期有关（P<0.05），并在肿块型直肠癌中明显增高（P<0.05）。    结论    HSP60在结直肠癌患者的血清、粪便中异常高表达。
Abstract:
Objective    To evaluate the expressions of human heat shock protein 60 (HSP60)  in serum and stool of colorectal cancer patients.     Methods    HSP60 was detected by indirect ELISA method in serum and stool samples from 20 normal controls and 40 pathologically proved colorectal cancer patients before operation.     Results    Compared with normal control, HSP60 increased significantly (P<0.05) in serum and stool samples of colorectal cancer patients. HSP60 in stool samples of colorectal cancer patients was different in the cases of different types of colorectal cancer(P<0.05), and increased in T4 and M4 of colorectal cancer.      Conclusion    HSP60 is overexpressed in serum and stool samples of colorectal cancer patients.

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更新日期/Last Update: 2008-10-15