[1]王祥峰,张连阳,何渝军,等.结直肠癌患者血清及粪便中热休克蛋白60检测的临床意义[J].第三军医大学学报,2007,29(13):1334-1336.
 WANG Xiang-feng,ZHANG Lian-yang,HE Yu-jun,et al.Clinical significance of HSP60 in serum and stool of colorectal cancer patients[J].J Third Mil Med Univ,2007,29(13):1334-1336.
点击复制

结直肠癌患者血清及粪便中热休克蛋白60检测的临床意义(/HTML )
分享到:

《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第13期
页码:
1334-1336
栏目:
论著
出版日期:
2007-07-15

文章信息/Info

Title:
Clinical significance of HSP60 in serum and stool of colorectal cancer patients
作者:
王祥峰张连阳何渝军李春穴刘宝华童卫东
第三军医大学大坪医院野战外科研究所:普通外科, 创伤一科
Author(s):
WANG Xiang-feng ZHANG Lian-yang HE Yu-jun LI Chun-xue LIU Bao-hua TONG Wei-dong
Department of General Surgery, Trauma Center, Institute of Surgery Research, Daping Hospital, Chongqing 400042, China
关键词:
结直肠癌HSP60 血清 粪便
Keywords:
colorectal cancer HSP60 serum stool
分类号:
R341; R730.43; R735.3
文献标志码:
A
摘要:
目的    探讨热休克蛋白(heat shock protein 60,HSP60)在结直肠癌患者血清和粪便中的表达及其对结直肠癌的诊断价值。    方法    采用间接ELISA法,检测40例结直肠癌患者及相应正常对照的血清及粪便中HSP60表达。    结果    HSP60在结直肠癌患者血清及粪便中较正常对照明显增高(P<0.05),且粪便浓度高于血清(P<0.05);结直肠癌患者粪便中HSP60含量与不同肿瘤浸润期及远处转移期有关(P<0.05),并在肿块型直肠癌中明显增高(P<0.05)。    结论    HSP60在结直肠癌患者的血清、粪便中异常高表达。
Abstract:
Objective    To evaluate the expressions of human heat shock protein 60 (HSP60)  in serum and stool of colorectal cancer patients.     Methods    HSP60 was detected by indirect ELISA method in serum and stool samples from 20 normal controls and 40 pathologically proved colorectal cancer patients before operation.     Results    Compared with normal control, HSP60 increased significantly (P<0.05) in serum and stool samples of colorectal cancer patients. HSP60 in stool samples of colorectal cancer patients was different in the cases of different types of colorectal cancer(P<0.05), and increased in T4 and M4 of colorectal cancer.      Conclusion    HSP60 is overexpressed in serum and stool samples of colorectal cancer patients.

相似文献/References:

[1]邵新宏,于游,张才全.miR-34a靶向调控NOTCH1基因对SW480细胞增殖的影响[J].第三军医大学学报,2012,34(22):2297.
 Shao Xinhong,Yu You,Zhang Caiquan.Inhibitory effects of miR-34a on NOTCH1 gene expression and SW480 cell proliferation[J].J Third Mil Med Univ,2012,34(13):2297.
[2]陈曦,黄悦,于彬,等.结直肠癌单克隆抗体的制备及生物学特性鉴定[J].第三军医大学学报,2007,29(10):896.
 CHEN Xi,HUANG Yue,YU Bin,et al.Preparing and identifying a monoclonal antibody against human colorectal carcinoma[J].J Third Mil Med Univ,2007,29(13):896.
[3]甘露,张超,曾冬竹,等.结直肠癌患者腹腔镜手术与开腹手术后并发症的风险因素分析[J].第三军医大学学报,2008,30(17):1668.
 GAN Lu,ZHANG Chao,ZENG Dong-zhu,et al.Laparoscopic-assisted versus open colorectal surgery: risk factor analysis for postoperative complications[J].J Third Mil Med Univ,2008,30(13):1668.
[4]赵菲,李世拥,于波,等.青年与老年结直肠癌临床病理特征的对比分析[J].第三军医大学学报,2007,29(06):544.
 ZHAO Fei,LI Shi-yong,YU Bo,et al.Comparative study on clinical pathological characteristics of young and old patients with colorectal cancer[J].J Third Mil Med Univ,2007,29(13):544.
[5]马千里,马华,陈曦,等.C-KIT蛋白在结直肠癌中的表达及临床意义[J].第三军医大学学报,2006,28(08):830.
[6]梁后杰,赵晓昕.结直肠癌肝转移新辅助化疗的共识与争议[J].第三军医大学学报,2009,31(01):26.
[7]马恒太,余佩武,葛海燕,等.体力活动对结直肠癌发病影响的重庆地区大样本病例-对照研究[J].第三军医大学学报,2005,27(22):2276.
[8]温玉婷,刘伟,杨爱军,等.IL-17和STAT3在结直肠癌组织中的表达及临床意义[J].第三军医大学学报,2011,33(17):1812.
 Wen Yuting,Liu Wei,Yang Aijun,et al.Expression of IL-17 and STAT3 in colorectal cancer tissue and its clinical significance[J].J Third Mil Med Univ,2011,33(13):1812.
[9]李靓,李洋,王继见.hTR反义寡核苷酸对结直肠癌SW480细胞的凋亡及凋亡诱导因子表达的影响[J].第三军医大学学报,2010,32(22):2400.
 Li Liang,Li Yang,Wang Jijian.Effect of hTR antisense oligodeoxynucleotide on apoptosis and expressions of apoptosis inducing factor in colon carcinoma cells SW480[J].J Third Mil Med Univ,2010,32(13):2400.
[10]赵海霞,牟东,薛世祥,等.结直肠癌组织中核干因子和增殖细胞核抗原的表达与血清叶酸水平的关系[J].第三军医大学学报,2011,33(10):995.
 Zhao Haixia,Mu Dong,Xue Shixiang,et al.Correlation between expression of nucleostemin and proliferating cell nuclear antigen in colorectal cancer tissues and serum folic acid concentrations[J].J Third Mil Med Univ,2011,33(13):995.

更新日期/Last Update: 2008-10-15