[1]杨兆瑞,吴晴,陈嘉薇,等.HIF-1α、JNK1、P-gp、MRP1和LRP蛋白在胃癌中的表达与临床病理及预后的关系[J].第三军医大学学报,2007,29(18):1755-1759.
　YANG Zhao-rui,WU Qing,CHEN Jia-wei,et al.Expressions, clinicopathological features and prognostic significance of HIF-1α, JNK1, P-gp, MRP1 and LRP proteins in human gastric carcinoma[J].J Third Mil Med Univ,2007,29(18):1755-1759.
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HIF-1α、JNK1、P-gp、MRP1和LRP蛋白在胃癌中的表达与临床病理及预后的关系(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第18期
页码:
1755-1759
栏目:
论著
出版日期:
2007-09-30

文章信息/Info

Title:
Expressions, clinicopathological features and prognostic significance of HIF-1α, JNK1, P-gp, MRP1 and LRP proteins in human gastric carcinoma
作者:
杨兆瑞; 吴晴; 陈嘉薇; 李大卫; 李淑霞
上海交通大学附属第一人民医院:病理科，肿瘤科
Author(s):
YANG Zhao-rui;  WU Qing;  CHEN Jia-wei;  LI Da-wei;  LI Shu-xia
Department of Pathology,Department of Oncology, The First People’s Hospital, Shanghai Jiaotong University, Shanghai 200080, China
关键词:
胃癌; 组织芯片; 缺氧; 多药耐药; 预后
Keywords:
gastric carcinoma;  tissue microarray;  hypoxia;  multidrug resistance;  prognosis
分类号:
R730.2;R730.43;R735.2
文献标志码:
A
摘要:
目的  探讨HIF-1α、JNK1、P-gp、MRP1和LRP蛋白在胃癌中的表达、临床病理关系及预后意义。  方法  应用组织芯片技术结合免疫组化染色，检测HIF-1α、JNK1、P-gp、MRP1和LRP在135例胃癌及27例正常胃黏膜中的表达。  结果  HIF-1α、JNK1、P-gp、MRP1和LRP在胃癌组织中阳性表达率高于正常胃黏膜（P<0.05）；TNM分期中的Ⅲ~Ⅳ期组和伴有淋巴结转移组的HIF-1α、P-gp、MRP1、LRP阳性表达率高于相应的Ⅰ~Ⅱ期组和无淋巴结转移组（P<0.05）；JNK1的阳性表达与临床病理各参数之间无明显相关。HIF-1α、JNK1、P-gp、MRP1和LRP各指标间存在正相关关系（P<0.01），并与生存期密切相关，阳性表达组较之阴性表达组平均生存期缩短（P<0.05）。  结论  HIF-1α、P-gp、MRP1、LRP阳性表达与胃癌侵袭、转移密切相关；HIF-1α、JNK1、P-gp、MRP1和LRP阳性表达可能具有胃癌预后判断的重要意义。
Abstract:
Objective    To investigate the expressions, clinical pathological features and prognostic significance of HIF-1α, JNK1 and multidrug resistance proteins: P-gp, MRP1 and LRP in human gastric carcinoma.     Methods    The tissue microarray technique and immunohistochemical EnVision method were used to detect HIF-1α, JNK1, P-gp, MRP1 and LRP proteins in 135 specimens of gastric carcinoma and 27 gastric mucosa tissues.     Results    In gastric carcinoma, the positive expression rate of HIF-1α, JNK1, P-gp, MRP1and LRP was higher than that in gastric mucosa tissues (P<0.05). The positive expression rate of HIF-1α, P-gp, MRP1 and LRP in the group of Ⅲ-Ⅳ stages (TNM stage) and the group of lymphonode metastasis was higher than that in the group of Ⅰ-Ⅱ states and the group of non-lymphonode metastasis respectively (P<0.05). The positive expression of JNK1 protein was not significantly correlated with clinicopathological features. A positive correlation was found between each other in expressions of HIF-1α, JNK1, P-gp, MRP1 and LRP proteins in gastric carcinoma (P<0.01). Their expressions were also correlated with survival time. The average survival time of the negative group was longer than that of positive group (P<0.05).     Conclusion    The positive expressions of HIF-1α, P-gp, MRP1 and LRP in gastric carcinoma are significantly correlated with the gastric carcinoma invasion and lymphonode metastasis. The positive expressions of HIF-1α, P-gp, MRP1, LRP and JNK1 proteins may be of predictive value in gastric carcinoma.

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更新日期/Last Update: 2008-07-16