[1]徐鹰妮,姜军,程鸿,等.ERα和ERβ在不同类型乳腺组织的表达及其意义[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1093-1095.
　XU Ying-ni,JIANG Jun,CHENG Hong,et al.Expression and significance of estrogen receptor isoforms in different breast tissues[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1093-1095.
点击复制

ERα和ERβ在不同类型乳腺组织的表达及其意义
(/HTML )
分享到：

陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第11期
页码:
1093-1095
栏目:
论著
出版日期:
2007-06-15

文章信息/Info

Title:
Expression and significance of estrogen receptor isoforms in different breast tissues
作者:
徐鹰妮; 姜军; 程鸿; 凡庆东; 谢竞; 周艳; 唐鹏
第三军医大学西南医院乳腺疾病中心
Author(s):
XU Ying-ni;  JIANG Jun;  CHENG Hong;  FAN Qing-dong;  XIE Jing;  ZHOU Yan;  TANG Peng
Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
关键词:
雌激素受体亚型; 乳腺肿瘤; 免疫组化
Keywords:
estrogen receptor isoforms;  breast neoplasms;  immunohistochemistry
分类号:
R347.913; R392-33; R737.9
文献标志码:
A
摘要:
目的    探讨乳腺正常组织经良性病变至癌变过程中雌激素受体（ER）亚型ERα和ERβ表达的变化及其意义。    方法    用免疫组化EnVision两步法检测94例女性浸润性乳腺癌、乳腺原位癌、良性病变和正常乳腺组织的雌激素受体亚型表达。    结果    ERα局限表达于乳腺腺上皮细胞核，相反ERβ广泛表达于腺上皮细胞、间质细胞、肌上皮细胞、内皮细胞和淋巴细胞，且多见细胞质、细胞核同时表达。正常乳腺组织和乳腺良性病变组织的上皮细胞ERα、ERβ染色结果相似；浸润性乳腺癌和乳腺原位癌的ERα表达明显降低；浸润性乳腺癌ERβ表达明显降低；浸润性乳腺癌和乳腺原位癌ERα、ERβ的共表达明显降低。    结论    ERβ广泛表达于间质细胞可能与其旁分泌作用有关。ERβ可能与乳腺癌的发生有关，而在乳腺癌中ERβ可能减弱对ERα的调节作用。
Abstract:
Objective    To investigate the estrogen receptor (ER) isoforms ERα and ERβ expressions and their relationship with clinicopathological parameters in normal breast tissue, benign breast diseases, breast cancer in situ and invasive breast cancer tissue.     Methods    Breast tissue samples were obtained, including normal breast tissue (14 cases), benign breast diseases (35 cases), breast cancer in situ (8 cases) and invasive breast cancer (37 cases). Immunohistochemistry was used to measure the expressions of ERα and ERβ in the breast tissues.     Results    The profiles of the ERα and ERβ expressions in normal tissues and the tissues of benign breast diseases were similar. Compared with normal breast tissues and benign breast diseases, ERα protein level was down-regulated in the tissues of breast cancer in situ and invasive breast cancer significantly (P<0.01); ERβ protein level was down-regulated in the tissues of invasive breast cancer notably (P<0.01); The coexpression of ERα and ERβ was decreased in the tissues of breast cancer in situ and invasive breast cancer remarkably (P<0.01).     Conclusion    ERβ may play a role in the human breast cancer probably by modulating ERα activity.

相似文献/References:

[1]陈庆峰,牛兆河,刘翠翠,等.鼠-人嵌合抗粘蛋白1 IgG1全抗体的构建及其功能初步分析[J].陆军军医大学学报(原第三军医大学学报),2012,34(17):1771.
　Chen Qingfeng,Niu Zhaohe,Liu Cuicui,et al.Construction and characterization of a mouse-human chimeric anti-mucin1 IgG antibody[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(11):1771.
[2]张彦,郑晓东,唐鹏,等.Sphk1基因对人乳腺癌MCF-7细胞增殖、凋亡和迁移能力的影响[J].陆军军医大学学报(原第三军医大学学报),2012,34(21):2141.
　Zhang Yan,Zheng Xiaodong,Tang Peng,et al.Sphk1 interference suppresses proliferation, apoptosis and migration in human MCF-7 breast cancer cells[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(11):2141.
[3]王杨,陈彬,姜晓梅,等.睾酮对乳腺癌细胞中FEN1表达的影响[J].陆军军医大学学报(原第三军医大学学报),2013,35(02):95.
　Wang Yang,Chen Bin,Jiang Xiaomei,et al.Effect of testosterone on FEN1 expression in breast cancer cells[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(11):95.
[4]李昌秀,曹友德.乳腺癌组织COX-2、VEGF-C的表达与淋巴结转移的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(20):1964.
　LI Chang-xiu,CAO You-de.Correlation of COX-2 and VEGF-C expressions in breast carcinoma with lymph node metastasis[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1964.
[5]周艳,姜军,张毅,等.雌激素受体β及其剪切变异体表达与雌激素受体阻滞剂治疗耐药的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(20):1999.
　ZHOU Yan,JIANG Jun,ZHANG Yi,et al.Relationship of estrogen receptor-beta and its isoform expressions with tamoxifen resistance in human breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1999.
[6]陈蓉,张伟国,张连阳,等.MRI评价乳腺癌行保乳术的可行性研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(17):1712.
　CHEN Rong,ZHANG Wei-guo,ZHANG Lian-yang,et al.Feasibility of utilizing MRI for assessing breast-conserving surgery of breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1712.
[7]周艳,张毅,梁燕,等.乳腺癌雌激素受体β表达与临床病理及预后标志物的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1090.
　ZHOU Yan,ZHANG Yi,LIANG Yan,et al.Association of ERβ expression with the clinical pathologic indexes and prognostic biomarkers of breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1090.
[8]彭俊华,糜漫天,朱俊东,等.辛基酚和三羟异黄酮对二甲基苯蒽诱发大鼠乳腺肿瘤的影响[J].陆军军医大学学报(原第三军医大学学报),2005,27(23):2317.
[9]陈庆峰,马中良,王笑峰,等.抗粘蛋白1单链抗体的构建及其功能初步分析[J].陆军军医大学学报(原第三军医大学学报),2010,32(16):1770.
　Chen Qingfeng,Ma Zhongliang,Wang Xiaofeng,et al.Construction and characterization of anti-mucin1 single chain Fv antibody fragment[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(11):1770.
[10]刘浩,曹友德,叶维霞,等.miR-206抑制乳腺癌MDA-MB-231细胞Cdc42蛋白表达及其对细胞骨架的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(06):568.
　Liu Hao,Cao Youde,YE Weixia,et al.miR-206 inhibits Cdc42 protein expression, invasion and migration of MDA-MB-231 cells[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(11):568.

更新日期/Last Update: 2008-10-23