[1]周艳,姜军,张毅,等.雌激素受体β及其剪切变异体表达与雌激素受体阻滞剂治疗耐药的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(20):1999-2001.
 ZHOU Yan,JIANG Jun,ZHANG Yi,et al.Relationship of estrogen receptor-beta and its isoform expressions with tamoxifen resistance in human breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(20):1999-2001.
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雌激素受体β及其剪切变异体表达与雌激素受体阻滞剂治疗耐药的关系(/HTML )
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第20期
页码:
1999-2001
栏目:
论著
出版日期:
2007-10-30

文章信息/Info

Title:
Relationship of estrogen receptor-beta and its isoform expressions with tamoxifen resistance in human breast cancer
作者:
周艳姜军张毅凡庆东范林军梁燕徐鹰妮
第三军医大学西南医院乳腺疾病中心
Author(s):
ZHOU Yan JIANG Jun ZHANG Yi FAN Qing-dong FAN Lin-jun LIANG Yan XU Ying-ni
Breast Disease Centre, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
关键词:
乳腺肿瘤雌激素受体内分泌治疗耐药
Keywords:
breast neoplasm estrogen receptors endocrine therapy resistance
分类号:
R737.9;R969.2;R977
文献标志码:
A
摘要:
目的  探讨雌激素受体β及其剪切变异体表达与乳腺癌他莫昔分治疗耐药的关系。 方法  选取接受他莫昔分治疗期间出现疾病进展的13例病例作为他莫昔分抵抗组,另外选取在年龄、绝经状态、随访时间、肿瘤分级分期和组织学表现上均接近,但是接受他莫昔分治疗期间未出现疾病进展的同样13例患者作为他莫昔分敏感组。采用免疫组化方法检测总ERβ、ERβ1 和ERβcx蛋白的表达。 结果  总ERβ表达在他莫昔分抵抗组和敏感组之间有显著性差异(P<0.05),总ERβ蛋白水平在他莫昔分敏感组明显高于他莫昔分抵抗组。ERβ1和ERβcx蛋白表达水平在2组间没有显著性差异。 结论  在预测内分泌治疗敏感性时,总ERβ以及ERβ异构型将和ERα状态一起,可能扮演重要角色,需要更大样本的前瞻性实验进行深入研究。
Abstract:
Objective    To study the relationship of estrogen receptor-beta and its isoform expressions with tamoxifen resistance in human breast cancer.     Methods    Thirty patients of primary breast cancer whose disease progressed while on tamoxifen therapy (tamoxifen resistant) and 13 matched patients of primary breast cancer without disease progression (tamoxifen sensitive) were included. The expression of total estrogen receptor beta (ERβ), ERβ1 and ERβcx in the specimens were tested by IHC.     Results    High total ERβ protein expressions were more in tamoxifen sensitive tumors than resistant tumors (P<0.05), while the expressions of ERβ1 and ERβcx protein showed no significant differences between the two groups.     Conclusion    The expressions of ERβ protein and its isoforms may differ in breast cancer patients who have different sensitivity to tamoxifen therapy.

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更新日期/Last Update: 2008-07-11