[1]陈绍兵,陈军华,王玉婷,等.甘草甜素对幼龄大鼠实验性肝纤维化疗效的研究[J].第三军医大学学报,2007,29(23):2261-2263.
 CHEN Shao-bing,CHEN Jun-hua,WANG Yu-ting,et al.Effect of glycyrrhizin on liver fibrosis in unmatured Wistar rats[J].J Third Mil Med Univ,2007,29(23):2261-2263.
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甘草甜素对幼龄大鼠实验性肝纤维化疗效的研究(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第23期
页码:
2261-2263
栏目:
论著
出版日期:
2007-12-15

文章信息/Info

Title:
Effect of glycyrrhizin on liver fibrosis in unmatured Wistar rats
作者:
陈绍兵陈军华王玉婷解元元詹学朱朝敏王绍映
重庆医科大学附属儿童医院感染消化科
Author(s):
CHEN Shao-bing CHEN Jun-hua WANG Yu-ting XIE Yuan-yuan ZHAN Xue ZHU Chao-min WANG Shao-ying
Department of Infectious Diseases and Digestive Diseases, Children’s Hospital, Chongqing Medical University
关键词:
甘草甜素幼龄大鼠肝纤维化病理学分级
Keywords:
glycyrrhizin unmatured Wistar rat liver fibrosis pathological classification
分类号:
R285.5; R361; R725.752
文献标志码:
A
摘要:
目的 观察甘草甜素抗幼龄大鼠实验性肝纤维化的效果,探讨甘草甜素对儿童肝纤维化治疗及预防的作用。 方法 制备幼龄大鼠实验性肝纤维化模型,用甘草甜素治疗,同步预防,观察幼龄大鼠一般情况、肝组织形态、光镜下病理变化。 结果 甘草甜素治疗组在幼龄大鼠一般情况和光镜下病理学分级中,明显优于同步预防组和肝纤维化对照组,而同步预防组又优于肝纤维化对照组,且疗程越长,效果越明显。 结论 甘草甜素对幼龄大鼠肝纤维化有明显治疗及预防作用。
Abstract:
Objective  To observe the effect of glycyrrhizin (Meineng) on liver fibrosis in unmatured Wistar rats for the prevention and therapy of children’s diseases.   Methods  The liver fibrosis model in rats aged 22-23 days was established by intraperitoneal injection of the mixture of CCl4 and peanut oil. Glycyrrhizin was used for prevention and treatment of liver fibrosis. Group A: after 2-, 4-, 6-, 8-week liver fibrosis establishment, the rats received glycyrrhizin till the experiment ended. Group B: Accompanying the rat model establishment, glycyrrhizin was used, and the rats were sacrificed at 2nd, 4th, 6th, 8th week after experiment started. Group C: Liver fibrosis establishment only. At the end of experiment, the morphological and pathological changes of liver tissues were observed in all rats.   Results  The morphological and pathological changes of the liver tissues in group A were much less than that in groups B and C. The therapeutic effect got better as treatment period prolonged.   Conclusion  Glycyrrhizin can efficaciously prevent and treat liver fibrosis in unmatured Wistar rats.

参考文献/References:

陈绍兵,陈军华,王玉婷,等.甘草甜素对幼龄大鼠实验性肝纤维化疗效的研究[J].第三军医大学学报,2007,29(23):2261-2263.

更新日期/Last Update: 2008-05-23