[1]陈丽,王玉华.孕期应用地塞米松对胎儿及胎鼠垂体肾上腺轴功能的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(13):1329-1330.
　CHEN Li,WANG Yu-hua.Effects of desamethasone in pregnancy on pituitary-adrenal functions of fetus and fetal rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(13):1329-1330.
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孕期应用地塞米松对胎儿及胎鼠垂体肾上腺轴功能的影响(/HTML )
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第13期
页码:
1329-1330
栏目:
论著
出版日期:
2007-07-15

文章信息/Info

Title:
Effects of desamethasone in pregnancy on pituitary-adrenal functions of fetus and fetal rats
作者:
陈丽; 王玉华
中国人民解放军第252医院妇产科
Author(s):
CHEN Li;  WANG Yu-hua
Department of Obstetrics and Gynecology, The 252th Hospital of PLA, Baoding 071000, China
关键词:
地塞米松; 胎儿; 治疗; 肾上腺
Keywords:
dexamethasone;  fetus;  treatment;  adrenal gland
分类号:
R714.250.5; R714.51; R977.11
文献标志码:
A
摘要:
目的    研究孕期地塞米松对子代垂体肾上腺功能的影响。    方法    2003年5至11月在我院住院分娩的孕妇中，取明确诊断为肝内胆汁淤积症（ICP）且使用地塞米松治疗的孕妇24例为观察组，检测胎儿脐血皮质醇和ACTH浓度；孕鼠地塞米松注射后检测胎鼠血皮质醇和ACTH浓度及垂体ACTH免疫组织化学表达。    结果    ICP孕妇使用地塞米松治疗后新生儿脐血皮质醇浓度较对照组降低及ACTH浓度升高（P<0.05）；孕鼠地塞米松注射后检测胎鼠血皮质醇浓度较对照组降低（P<0.05），胎鼠血ACTH浓度升高及胎鼠垂体ACTH免疫组织化学表达增强（P<0.05）。    结论    孕期使用地塞米松对新生儿肾上腺功能存在近期影响。
Abstract:
Objective    To evaluate the effects of desamethasone in pregnancy on fetal pituitary-adrenal functions.     Methods    From May 2003 to November 2003 24 cases of intrahepatic cholestasis of pregancy (ICP) in the third trimester were treated with dexamethasone. The levels of ACTH and cortisone in the umbilical blood were detected after delivery. The pregnant Wistar rats were intramuscularly injected of dexamethasone (1 mg·kg-1·d-1) from the pregnancy day 15 for 5 days as group B, while the rats in group A received no dexamethasone as control group. The levels of ACTH and cortisone of the rat fetus as well as the ACTH in fetal pituitary gland by immunohistochemistry were examined.     Results    The ACTH level in the umbilical blood of the fetus increased and the cortisone level decreased as compared to that of the control group. Treatment with desamethasone to pregnant rats resulted in enhanced expression of ACTH, increased serum ACTH concentration, and decreased concentration of cortisol in the rat fetal pituitary gland.      Conclusion    Treatment with dexamethasone in pregnancy causes some impact on the adrenal gland of the newborn rats in the near future.

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更新日期/Last Update: 2008-10-15