[1]李昌秀,曹友德.乳腺癌组织COX-2、VEGF-C的表达与淋巴结转移的关系[J].第三军医大学学报,2007,29(20):1964-1967.
 LI Chang-xiu,CAO You-de.Correlation of COX-2 and VEGF-C expressions in breast carcinoma with lymph node metastasis[J].J Third Mil Med Univ,2007,29(20):1964-1967.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第20期
页码:
1964-1967
栏目:
论著
出版日期:
2007-10-30

文章信息/Info

Title:
Correlation of COX-2 and VEGF-C expressions in breast carcinoma with lymph node metastasis
作者:
李昌秀曹友德
重庆医科大学病理学教研室
Author(s):
LI Chang-xiu CAO You-de
Department of Pathology, Chongqing Medical University, Chongqing 400016, China
关键词:
乳腺肿瘤血管内皮生长因子-C环氧化酶-2淋巴管生成
Keywords:
breast neoplasma vascular endothelial growth factor-C cyclooxygenase-2 lymphoangiogenesis
分类号:
R73-37;R730.231;R737.9
文献标志码:
A
摘要:
目的  研究COX-2、VEGF-C在乳腺癌组织中的表达及其与淋巴管生成、淋巴结转移间的相关性。  方法  采用免疫组化学SP法检测46例浸润性导管癌组织中COX-2、VEGF-C的表达,通过淋巴管特异性标记物D2-40记数淋巴管密度(LVD),分析COX-2、VEGF-C的表达与淋巴管生成和淋巴结癌组织转移的相关性。  结果  ①乳腺癌组织COX-2、VEGF-C表达阳性率分别为73.91%(34/46)和71.74%(33/46)。②有淋巴结转移组COX-2阳性率为86.48%(32/37)、VEGF-C为81.08%(30/37),D2-40阳性淋巴管密度为(13.350±3.097)/×200。无淋巴结转移组COX-2为22.22%(2/9)、VEGF-C为33.33%(3/9)、LVD为(9.560±2.031)/×200,转移组中COX-2、VEGF-C的表达及淋巴管密度均明显高于无转移组(P<0.01)。③VEGF-C表达与COX-2表达呈正相关(r=0.757,P<0.01),并且COX-2、VEGF-C的表达与LVD也呈正相关(P<0.01)。  结论  VEGF-C、COX-2在人乳腺癌组织呈高水平表达,其表达与肿瘤淋巴管密度及癌组织淋巴结转移有关;COX-2可能通过诱导VEGF-C表达促进肿瘤淋巴管生成和淋巴结转移。
Abstract:
Objective    To investigate the expressions of COX-2 and VEGF-C in breast carcinoma and their correlation with lymphangiogenesis and lymph node metastasis.     Methods    The expressions of COX-2 and VEGF-C and D2-40 were evaluated in 46 cases of breast carcinoma by immunohistochemical staining SP methods. The lymphatic vessels density (LVD) in tumor was counted through the special marker D2-40.     Results    The positive rate of COX-2 and of VEGF-C was 73.91% (34/46) and 71.74% (33/46) respectively in breast carcinoma tissues. The positive rate of COX-2 and VEGF-C was 86.48% (32/37) and 81.08% (30/37), and LVD was (13.350±3.097)/×200 in the lymph node metastasis group, while that in non-lymph-node metastasis group was 22.22% (2/9), 33.33% (3/9) and (9.560±2.031)/×200 respectively, with significant difference between the two groups (P<0.01). VEGF-C expression was positively correlated with COX-2 expression (r=0.757, P<0.01). The expressions of COX-2 and VEGF-C were positively correlated with LVD (P<0.01).     Conclusion    The expressions of COX-2 and VEGF-C were high in breast carcinoma, which were closely related with tumor LVD and lymph node metastasis. A positive correlation was found between the expressions of VEGF-C and COX-2 in breast carcinoma. COX-2 may promote tumor lymphangiogenesis and metastasis of tumor lymph node by inducing VEGF-C expression.

参考文献/References:

李昌秀,曹友德. 乳腺癌组织COX-2、VEGF-C的表达与淋巴结转移的关系[J].第三军医大学学报,2007,29(20):1964-1967.

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更新日期/Last Update: 2008-07-11