[1]李昌秀,曹友德.乳腺癌组织COX-2、VEGF-C的表达与淋巴结转移的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(20):1964-1967.
 LI Chang-xiu,CAO You-de.Correlation of COX-2 and VEGF-C expressions in breast carcinoma with lymph node metastasis[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(20):1964-1967.
点击复制

乳腺癌组织COX-2、VEGF-C的表达与淋巴结转移的关系(/HTML )
分享到:

陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第20期
页码:
1964-1967
栏目:
论著
出版日期:
2007-10-30

文章信息/Info

Title:
Correlation of COX-2 and VEGF-C expressions in breast carcinoma with lymph node metastasis
作者:
李昌秀曹友德
重庆医科大学病理学教研室
Author(s):
LI Chang-xiu CAO You-de
Department of Pathology, Chongqing Medical University, Chongqing 400016, China
关键词:
乳腺肿瘤血管内皮生长因子-C环氧化酶-2淋巴管生成
Keywords:
breast neoplasma vascular endothelial growth factor-C cyclooxygenase-2 lymphoangiogenesis
分类号:
R73-37;R730.231;R737.9
文献标志码:
A
摘要:
目的  研究COX-2、VEGF-C在乳腺癌组织中的表达及其与淋巴管生成、淋巴结转移间的相关性。  方法  采用免疫组化学SP法检测46例浸润性导管癌组织中COX-2、VEGF-C的表达,通过淋巴管特异性标记物D2-40记数淋巴管密度(LVD),分析COX-2、VEGF-C的表达与淋巴管生成和淋巴结癌组织转移的相关性。  结果  ①乳腺癌组织COX-2、VEGF-C表达阳性率分别为73.91%(34/46)和71.74%(33/46)。②有淋巴结转移组COX-2阳性率为86.48%(32/37)、VEGF-C为81.08%(30/37),D2-40阳性淋巴管密度为(13.350±3.097)/×200。无淋巴结转移组COX-2为22.22%(2/9)、VEGF-C为33.33%(3/9)、LVD为(9.560±2.031)/×200,转移组中COX-2、VEGF-C的表达及淋巴管密度均明显高于无转移组(P<0.01)。③VEGF-C表达与COX-2表达呈正相关(r=0.757,P<0.01),并且COX-2、VEGF-C的表达与LVD也呈正相关(P<0.01)。  结论  VEGF-C、COX-2在人乳腺癌组织呈高水平表达,其表达与肿瘤淋巴管密度及癌组织淋巴结转移有关;COX-2可能通过诱导VEGF-C表达促进肿瘤淋巴管生成和淋巴结转移。
Abstract:
Objective    To investigate the expressions of COX-2 and VEGF-C in breast carcinoma and their correlation with lymphangiogenesis and lymph node metastasis.     Methods    The expressions of COX-2 and VEGF-C and D2-40 were evaluated in 46 cases of breast carcinoma by immunohistochemical staining SP methods. The lymphatic vessels density (LVD) in tumor was counted through the special marker D2-40.     Results    The positive rate of COX-2 and of VEGF-C was 73.91% (34/46) and 71.74% (33/46) respectively in breast carcinoma tissues. The positive rate of COX-2 and VEGF-C was 86.48% (32/37) and 81.08% (30/37), and LVD was (13.350±3.097)/×200 in the lymph node metastasis group, while that in non-lymph-node metastasis group was 22.22% (2/9), 33.33% (3/9) and (9.560±2.031)/×200 respectively, with significant difference between the two groups (P<0.01). VEGF-C expression was positively correlated with COX-2 expression (r=0.757, P<0.01). The expressions of COX-2 and VEGF-C were positively correlated with LVD (P<0.01).     Conclusion    The expressions of COX-2 and VEGF-C were high in breast carcinoma, which were closely related with tumor LVD and lymph node metastasis. A positive correlation was found between the expressions of VEGF-C and COX-2 in breast carcinoma. COX-2 may promote tumor lymphangiogenesis and metastasis of tumor lymph node by inducing VEGF-C expression.

相似文献/References:

[1]周艳,姜军,张毅,等.雌激素受体β及其剪切变异体表达与雌激素受体阻滞剂治疗耐药的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(20):1999.
 ZHOU Yan,JIANG Jun,ZHANG Yi,et al.Relationship of estrogen receptor-beta and its isoform expressions with tamoxifen resistance in human breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(20):1999.
[2]陈蓉,张伟国,张连阳,等.MRI评价乳腺癌行保乳术的可行性研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(17):1712.
 CHEN Rong,ZHANG Wei-guo,ZHANG Lian-yang,et al.Feasibility of utilizing MRI for assessing breast-conserving surgery of breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(20):1712.
[3]周艳,张毅,梁燕,等.乳腺癌雌激素受体β表达与临床病理及预后标志物的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1090.
 ZHOU Yan,ZHANG Yi,LIANG Yan,et al.Association of ERβ expression with the clinical pathologic indexes and prognostic biomarkers of breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(20):1090.
[4]徐鹰妮,姜军,程鸿,等.ERα和ERβ在不同类型乳腺组织的表达及其意义[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1093.
 XU Ying-ni,JIANG Jun,CHENG Hong,et al.Expression and significance of estrogen receptor isoforms in different breast tissues[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(20):1093.
[5]程鸿,姜军,杨新华,等.不同方案新辅助化疗对乳腺癌激素受体表达的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(10):973.
 CHENG Hong,JIANG Jun,YANG Xin-hua,et al.Influence of neoadjuvant chemotherapy of different regimen on expression of hormonal receptors in breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(20):973.
[6]彭俊华,糜漫天,朱俊东,等.辛基酚和三羟异黄酮对二甲基苯蒽诱发大鼠乳腺肿瘤的影响[J].陆军军医大学学报(原第三军医大学学报),2005,27(23):2317.
[7]甘长清,王小毅.经动脉灌注新辅助化疗对局部进展期乳腺癌激素受体表达水平的上调作用[J].陆军军医大学学报(原第三军医大学学报),2009,31(18):1794.
 GAN Chang-qing,WANG Xiao-yi.Transarterial infusion neoadjuvant chemotherapy up-regulates expressions of hormone receptors in local advanced breast cancer tissues[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(20):1794.
[8]刘浩,曹友德,叶维霞,等.miR-206抑制乳腺癌MDA-MB-231细胞Cdc42蛋白表达及其对细胞骨架的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(06):568.
 Liu Hao,Cao Youde,YE Weixia,et al.miR-206 inhibits Cdc42 protein expression, invasion and migration of MDA-MB-231 cells[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(20):568.
[9]吴岩,侍立峰.38例卵巢转移性癌临床诊治疗效分析[J].陆军军医大学学报(原第三军医大学学报),2010,32(10):1124.
[10]张园园,胡国华,袁琨,等.SDF-1/CXCR4对喉癌细胞归巢的作用[J].陆军军医大学学报(原第三军医大学学报),2010,32(12):1316.
 Zhang Yuanyuan,Hu Guohua,Yuan Kun,et al.Effect of SDF-1/CXCR4 axis to homing of laryngeal carcinoma cell Hep-2[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(20):1316.

更新日期/Last Update: 2008-07-11