[1]闵发胜,陈正堂.人非小细胞肺癌与外周血淋巴细胞表达LRP的相关性研究[J].第三军医大学学报,2007,29(17):1699-1701.
 MIN Fa-sheng,CHEN Zheng-tang.Correlation between expression of lung resistance-related protein in non-small cell lung cancer and that in peripheral blood lymphocytes[J].J Third Mil Med Univ,2007,29(17):1699-1701.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第17期
页码:
1699-1701
栏目:
论著
出版日期:
2007-09-15

文章信息/Info

Title:
Correlation between expression of lung resistance-related protein in non-small cell lung cancer and that in peripheral blood lymphocytes
作者:
闵发胜陈正堂
第三军医大学新桥医院全军肿瘤研究所
Author(s):
MIN Fa-sheng CHEN Zheng-tang
Cancer Research Center, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
关键词:
肺耐药相关蛋白非小细胞肺癌外周血淋巴细胞
Keywords:
lung resistance-related protein non-small cell lung cancer peripheral blood lymphocytes
分类号:
R341; R730.23; R734.2
文献标志码:
A
摘要:
目的  探讨肺耐药相关蛋白(lung resistance-related protein, LRP)在人非小细胞肺癌(non-small cell lung cancer, NSCLC)癌组织、癌旁组织和外周血淋巴细胞(peripheral blood lymphocytes, PBL)中的表达及其相关性。 方法  采用S-P免疫组织化学方法检测49例人NSCLC癌组织、癌旁组织和 PBL中LRP的表达及10例正常人PBL中LRP的表达。 结果  NSCLC癌组织、癌旁组织和PBL的LRP表达阳性率分别为78.2%、46.4%和66.8%,其中癌组织的LRP表达阳性率明显高于癌旁组织(P<0.05),且与PBL的LRP表达呈正相关。在各病理类型的NSCLC中,腺癌表达阳性率最高(90.9%),鳞癌次之(55.6%),差异显著(P<0.01)。10例正常人PBL的LRP表达阳性率(20%)显著低于NSCLC患者(P<0.05)。 结论  检测NSCLC患者PBL的LRP表达可间接反映癌组织的LRP表达状况。
Abstract:
Objective    To explore the correlation between the expression of lung resistance-related protein (LRP) in non-small cell lung cancer (NSCLC) and that in peripheral blood lymphocytes (PBL).     Methods    The S-P immunohistochemistry was used to detect the expression of LRP in specimens and PBL of 49 patients with NSCLC. Para-carcinoma tissues and PBL of 10 normal people were used as controls.     Results    The positive expression rate of LRP was 78.2%, 46.4% and 66.8% in carcinoma tissues, para-carcinoma tissues and PBL, respectively. The expression rate of LRP in carcinoma tissues was higher than that in para-carcinoma tissues (P<0.05), and positively correlated with that in PBL of the patients. The expression rate of LRP in adenocarcinomas was higher than that in squamous cell carcinomas (P<0.01). The expression rate of LRP in the normal people was lower than in NSCLC patients(P<0.05).      Conclusion    The expression of LRP in PBL of  NSCLC patients may indirectly represent the expression of LRP in carcinoma tissues.

参考文献/References:

闵发胜,陈正堂.  人非小细胞肺癌与外周血淋巴细胞表达LRP的相关性研究[J].第三军医大学学报,2007,29(17):1699-1701.

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更新日期/Last Update: 2008-07-21