[1]王钰琦,郑昕,周乃康,等.18F-FMISO在肺癌模型小鼠体内的生物分布及PET显像研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(18):1794-1796.
　WANG Yu-qi,ZHENG Xin,ZHOU Nai-kang,et al.Biodistribution and PET imaging of 18F-fluoromisonidazole in murine model of lung carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(18):1794-1796.
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18F-FMISO在肺癌模型小鼠体内的生物分布及PET显像研究(/HTML )
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第18期
页码:
1794-1796
栏目:
论著
出版日期:
2007-09-30

文章信息/Info

Title:
Biodistribution and PET imaging of 18F-fluoromisonidazole in murine model of lung carcinoma
作者:
王钰琦; 郑昕; 周乃康; 张锦明; 柳曦; 张竞
中国人民解放军总医院：胸外科，核医学科
Author(s):
WANG Yu-qi;  ZHENG Xin;  ZHOU Nai-kang;  ZHANG Jin-ming;  LIU Xi;  ZHANG Jing
Division of General Thoracic Surgery, Department of Nuclear Medicine, General Hospital of PLA, Beijing 100853, China
关键词:
18F-FMISO; 乏氧显像剂; 生物分布; 肺部肿瘤; 动物模型
Keywords:
18F-fluoromisonidazole;  hypoxic imaging contract;  biodistribution;  pulmonary neoplasms;  animal model
分类号:
R730.44;R969.1;R981.1
文献标志码:
A
摘要:
目的  评价乏氧显像剂18F-硝基咪唑丙醇（18F-FMISO）在肺腺癌动物模型中的诊断价值。  方法  荷肺腺癌T739小鼠经尾静脉注入18F-FMISO后不同时间（30、60、90、120 min）处死，测量18F-FMISO的生物分布，并行PET显像。对照组小鼠在注入18F-氟脱氧葡萄糖（18F-FDG）后行PET显像。  结果  荷瘤鼠肿瘤PET显像清晰。生物分布研究表明肿瘤有明显的放射性摄取。在肾脏和肝脏有较高的放射性分布。肿瘤对血和肌肉的T/NT比值均大于2。  结论  肺部恶性肿瘤组织中18F-FMISO摄取高于正常组织，可通过PET清晰显像，为进一步临床应用于肿瘤的乏氧诊断提供了依据。
Abstract:
Objective    To evaluate the diagnosis value of a hypoxic contrast, 18F-fluoromisonidazole (18F-FMISO), in murine model of pulmonary carcinoma.     Methods    After the injection of 18F-FMISO into the tail, 48 T739 mice bearing the pulmonary adenocarcinoma were sacrificed and divided into 4 groups according different killing times (30, 60, 90 and 120 min). The biodistribution was measured and PET scanning was performed. Another 8 tumor bearing T734 mice served as control, and PET was carried out after the injection of 18F-FDG.     Results    The tumor PET images with 18F-FMISO were clear. Considerable radioactive uptake on tumor was observed. Higher radioactivity was found in the kidneys and liver. The T/NT ratios of tumor/muscle and tumor/blood were above 2.0.     Conclusion    The uptake of 18F-FMISO in pulmonary malignant tissues is higher than that in normal tissues, thus the pulmonary neoplasm can be identified accurately with PET imaging. Our preliminary study provides a basis for further clinical hypoxic diagnose of the tumor.
更新日期/Last Update: 2008-07-16