[1]杨朝霞,代东伶,沈薇.虫草菌丝和还原型谷胱甘肽对非酒精性脂肪肝大鼠模型治疗效果的研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(22):2176-2178.
 YANG Zhao-xia,DAI Dong-ling,SHEN Wei.Effect of cordyceps sinensis and reduced glutathione on experimental mouse model with non-alcoholic fatty liver disease[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(22):2176-2178.
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虫草菌丝和还原型谷胱甘肽对非酒精性脂肪肝大鼠模型治疗效果的研究(/HTML )
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第22期
页码:
2176-2178
栏目:
论著
出版日期:
2007-11-30

文章信息/Info

Title:
Effect of cordyceps sinensis and reduced glutathione on experimental mouse model with non-alcoholic fatty liver disease
作者:
杨朝霞代东伶沈薇
重庆医科大学附属第二医院消化内科
Author(s):
YANG Zhao-xia DAI Dong-ling SHEN Wei
Department of Gastroenterology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
关键词:
非酒精性脂肪肝虫草菌丝 还原型谷胱甘肽
Keywords:
non-alcoholic fatty liver cordyceps sinensis reduced glutathione
分类号:
R282.71;R575.505;R977.4
文献标志码:
A
摘要:
目的  比较虫草菌丝(CS,商品名金水宝)和还原型谷胱甘肽(GSH,商品名阿托莫兰)对实验性大鼠非酒精性脂肪性肝病(NAFLD)的治疗效果,探讨其可能的分子机制。  方法  高脂饮食建立大鼠NAFLD模型,分别给予CS和GSH进行干预。观察肝脏组织学变化,检测血清和肝组织TG、FFA变化和肝组织SOD、ATP含量。   结果  ①随着NAFLD造模的进行,大鼠肝组织广泛脂肪变性,炎性细胞浸润、坏死,局部纤维组织增生。血清和肝组织TG、FFA升高。肝SOD含量和ATP含量下降。②CS组肝组织脂肪变性明显减轻,仅有轻微炎性细胞浸润,未见坏死灶及纤维组织增生,血清和肝组织TG、FFA显著降低(P<0.05);肝SOD含量和ATP含量也明显增加(P<0.01)。③GSH组肝组织广泛脂肪变性,炎症细胞浸润,灶性及点状坏死,但是未见纤维组织增生;肝SOD含量显著增加(P<0.01),但血清和肝组织TG、FFA和肝ATP含量均无明显变化(P>0.05)。  结论  CS和GSH均对NAFLD有治疗效果,能阻止肝纤维化的发生,而在纠正脂代谢紊乱,阻止脂质在肝沉积,纠正肝细胞能量失衡方面,CS的作用更明显。
Abstract:
Objective    To compare the therapeutic effects of cordyceps sinesis (CS) and reduced glutathione on experimental non-alcoholic fatty liver disease (NAFLD) rats and explore the possible molecular mechanisms.     Methods    After NAFLD rats were induced by high-fat diet and were treated by CS and reduced glutathione. The histopathologic changes of livers were evaluated. The levels of TG and FFA in serum and liver were measured.  The levels of SOD and ATP in liver were measured too.     Results    (1)In the development of NAFLD, extensive adipose degeneration, inflammatory cell infiltration and necrosis, local fibrous tissue hyperplasia were found in the liver. The increase of TG, FFA in the serum and liver and decrease of SOD and ATP in the liver were seen. (2)In CS treated group, adipose degeneration had been alleviated with slightly inflammatory cells infiltration and no necrosis or fibrosis had been found. The concentrations of TG and FFA were decreased in the serum and liver, but SOD and ATP increased. (3)In glutathione treated group, adipose degeneration of liver and inflammatory cells infiltration remained obviously with focus or punctiform necrosis, but without fibrosis. The increase of SOD in liver was distinguished. No changes of TG, FFA, UCP-2 and ATP had been detected.     Conclusion    Both CS and reduced glutathione have therapeutic effects on NAFLD, by preventing the generation of liver fibrosis. CS has a better therapeutic effects on metabolic disturbance or accumulation of lipid and energy metabolic imbalance of liver cells.

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更新日期/Last Update: 2008-07-01