[1]张毅,周艳,郭美琴,等.全乳大切片观察新辅助化疗后乳腺癌浸润性生长特征变化[J].陆军军医大学学报(原第三军医大学学报),2007,29(21):2083-2085.
　ZHANG Yi,ZHOU Yan,GUO Mei-qin,et al.Infiltrating characteristics of breast cancer after neoadjuvant chemotherapy: whole breast serial subsection observation[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(21):2083-2085.
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第21期
页码:
2083-2085
栏目:
论著
出版日期:
2007-11-15

文章信息/Info

Title:
Infiltrating characteristics of breast cancer after neoadjuvant chemotherapy: whole breast serial subsection observation
作者:
张毅; 周艳; 郭美琴; 郭德玉; 封传悦; 姜军
第三军医大学西南医院：乳腺中心，病理学研究所
Author(s):
ZHANG Yi;  ZHOU Yan;  GUO Mei-qin;  GUO De-yu;  FENG Chuan-yue;  JIANG Jun
Breast Disease Center, Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
关键词:
乳腺癌; 全乳大切片; 新辅助化疗
Keywords:
breast cancer;  whole breast subserial section;  neoadjuvant chemotherapy
分类号:
R446.8; R730.23; R737.9
文献标志码:
A
摘要:
目的  探讨乳腺癌的浸润特征及新辅助化疗对乳腺癌浸润特点的改变。  方法  采用全乳大切片技术对比研究病理分期为Ⅰ~Ⅲ期93例行术前化疗与31例未行术前化疗乳腺癌的浸润特征。  结果  对照组皮肤皮下浸润阳性35.5%，发生大导管浸润者25.8%，对肿瘤周围血管浸润者38.7%，肿瘤微血管计数(MVD)17.2±9.5;新辅助化疗后皮肤皮下浸润阳性9.7%,大导管浸润阳性8.6%,肿瘤周围血管浸润阳性11.8%,MVD 8.0±4.4,各项指标均明显低于对照组（P<0.05）。  结论  新辅助化疗显著减轻乳腺癌对周围组织的浸润，可增加保乳机会。
Abstract:
Objective    To study the infiltrating characteristics of breast cancer and the influence of neoadjuvant chemotherapy to it.    Methods    The whole breast subserial section technique was used to study infitrating characteristics in 93 cases of breast cancer with neoadjuvant chemotherapy and 31 cases without from June 2005 to August 2006.     Results    In those without neoadjuvant chemotherapy, skin-subcutaneous tissue involvement was 35.5%, big duct involvement 25.8%, invasion to blood vessel around tumor 38.7% and tumor microvascular density (MVD) was (17.2±9.5). In those with neoadujvant chemotherapy, skin-subcutaneous tissue involvement was 9.7%, big duct involvement 8.6%, blood vessel invasion 11.8% and tumor MVD was (8±4.4). Every index after neoadjuvant chemotherapy was significantly lower (P<0.05).     Conclusion    Neoadjuvant chemotherapy can abate infiltration to peripheral tissues of breast cancer and raise the chance of breast conserving therapy.

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更新日期/Last Update: 2008-07-02