[1]李艳秋,李建春,关洪全,等.肺癌患者外周血Th1/Th2细胞因子及IL-18水平变化与肿瘤分期的关系[J].第三军医大学学报,2007,29(08):731-732.
 LI Yan-qiu,LI Jian-chun,GUAN Hong-quan,et al.Changes of IL-18 and Th1/Th2 in serum of lung cancer patients and their relationship with tumor staging[J].J Third Mil Med Univ,2007,29(08):731-732.
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肺癌患者外周血Th1/Th2细胞因子及IL-18水平变化与肿瘤分期的关系(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第08期
页码:
731-732
栏目:
论著
出版日期:
2007-04-30

文章信息/Info

Title:
Changes of IL-18 and Th1/Th2 in serum of lung cancer patients and their relationship with tumor staging
作者:
李艳秋李建春关洪全蔡玉文
辽宁中医药大学研究生学院
Author(s):
LI Yan-qiu LI Jian-chun GUAN Hong-quan CAI Yu-wen
Graduate School, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China
关键词:
肺癌IL-18Th1/Th2细胞因子
Keywords:
lung cancer IL-18 Th1/Th2 cytokines
分类号:
R392.11;R730.43;R734.2
文献标志码:
A
摘要:
目的     探讨肺癌患者血清IL-18及TH细胞因子水平与临床肿瘤分期以及与病理分期之间的关系。     方法     应用ELISA法检测 109例肺癌患者血清细胞因子IL-18、Th1( IL-2、TNF-α) 及Th2(IL-4、IL-10)水平。 30例正常人外周血细胞因子作对照。     结果     肺癌组IL-18、Th1( IL-2、TNF-α)水平明显低于正常组,Th2(IL-4、IL-10)水平高于正常组(P<0.05);小细胞癌患者的外周血IL-18水平比鳞状细胞癌及肺腺癌水平明显降低(P<0.01);随着肺癌(分期)的加重,其外周血IL-18及Th1细胞因子(IL-2、TNF-α)水平逐渐下降。     结论     外周血IL-18及TH细胞因子水平能反映患者的免疫功能状态,并可能做为提示预后的指标之一。
Abstract:
Objective     To investigate the levels of IL-18, Th1(IL-2, TNF-α) and Th2(IL-4, IL-10) in patients with lung cancer and their relation to clinical pathological stages.      Methods     Totally 109 lung cancer patients were of 45 squamous cancer, 40 adenocarcinoma, 18 small cell lung cancer and 6 large cell carcinoma. Serum levels of IL-18, TNF-α, IL-2, IL-4 and IL-10 were determined by using an ELISA assay in 109 lung cancer patients and in 30 normal people.      Results     The levels of IL-18, TNF-α and IL-2 were significantly lower and the levels of IL-4 and IL-10 were significantly higher in lung cancer patients than in controls (P<0.05). The level of IL-18 in small cell lung cancer was lower than that in other kinds of lung cancer(P<0.01). With progress of the clinical pathological stages, serum levels of IL-18, IL-2 and TNF-α decreased accordingly.      Conclusion     Serum levels of IL-18 and Th1/Th2 subsets may be related to immune functions of lung cancer patients and be a good sign of prognosis.

参考文献/References:

李艳秋,李建春,关洪全,等. 肺癌患者外周血Th1/Th2细胞因子及IL-18水平变化与肿瘤分期的关系[J]. 第三军医大学学报, 2007, 29(8):731-732.

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更新日期/Last Update: 2008-10-28