[1]刘茜,吴亚梅,徐玲,等.急性缺氧诱导C57BL/6J小鼠瘦素表达增加[J].陆军军医大学学报(原第三军医大学学报),2007,29(13):1311-1312.
　LIU Xi,WU Ya-mei,XU Ling,et al.Influence of hypoxia on leptin expression in C57BL/6J mice[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(13):1311-1312.
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第13期
页码:
1311-1312
栏目:
论著
出版日期:
2007-07-15

文章信息/Info

Title:
Influence of hypoxia on leptin expression in C57BL/6J mice
作者:
刘茜; 吴亚梅; 徐玲; 唐超; 种银保
重庆市第三人民医院老年呼吸科；重庆医科大学附属第一医院肺科；第三军医大学新桥医院设备科
Author(s):
LIU Xi;  WU Ya-mei;  XU Ling;  TANG Chao;  ZHONG Yin-bao
Department of Geratology, The Third People’s Hospital of Chongqing, Chongqing 400014; Department of Lung Diseases, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016;Department of facility, Xinqiao Hospital, Chongqing 400037, China
关键词:
缺氧; 瘦素; 呼吸
Keywords:
hypoxia;  leptin;  respiration
分类号:
R341; R364.4; R446.1
文献标志码:
A
摘要:
目的    观察缺氧后小鼠血清和中枢神经系统瘦素水平的变化。    方法    以C57BL/6J小鼠为研究对象，利用医学自动测控缺氧仓(XQ-I型)复制机体常压缺氧状态，分为正常组、缺氧24 h组、缺氧48 h组，收集小鼠血清、脑脊液和脑组织（去除大脑和小脑后）匀浆标本，利用放射免疫方法检测瘦素浓度。    结果    缺氧24、48 h组小鼠血清、脑脊液和脑组织内的瘦素水平均显著高于未缺氧小鼠(P<0.05)，但缺氧24 h组和缺氧48 h组之间没有明显差别(P>0.05)。     结论    缺氧可作为一种独立的诱导因素促进小鼠脂肪组织瘦素的表达，同时使进入中枢神经系统内的瘦素水平亦明显增加。
Abstract:
Objective    To investigate the influence of hypoxia on leptin expression in serum, CSF and brain tissue of C57BL/6J mice.     Methods    C57BL/6J mice were divided into 3 groups: the normal control, 24-hour hypoxia group and 48-hour hypoxia group. The latter two groups exposed to hypoxia in the man-made auto pressure and hypoxia control cabin (XQ-I). Radioimmunoassay was used to detect the leptin level.     Results    The leptin level in the serum, CSF and brain tissue of mice exposed to hypoxia were higher than that of normal control, but no difference was found between 24-hour hypoxia group and 48-hour hypoxia group.     Conclusion    Hypoxia probably induces the increasing of leptin expression in fat tissue, as well as in the central nervous system.

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更新日期/Last Update: 2008-10-15