[1]刘茜,吴亚梅,徐玲,等.急性缺氧诱导C57BL/6J小鼠瘦素表达增加[J].第三军医大学学报,2007,29(13):1311-1312.
　LIU Xi,WU Ya-mei,XU Ling,et al.Influence of hypoxia on leptin expression in C57BL/6J mice[J].J Third Mil Med Univ,2007,29(13):1311-1312.
点击复制

急性缺氧诱导C57BL/6J小鼠瘦素表达增加(/HTML )
分享到：

《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第13期
页码:
1311-1312
栏目:
论著
出版日期:
2007-07-15

文章信息/Info

Title:
Influence of hypoxia on leptin expression in C57BL/6J mice
作者:
刘茜; 吴亚梅; 徐玲; 唐超; 种银保
重庆市第三人民医院老年呼吸科；重庆医科大学附属第一医院肺科；第三军医大学新桥医院设备科
Author(s):
LIU Xi;  WU Ya-mei;  XU Ling;  TANG Chao;  ZHONG Yin-bao
Department of Geratology, The Third People’s Hospital of Chongqing, Chongqing 400014; Department of Lung Diseases, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016;Department of facility, Xinqiao Hospital, Chongqing 400037, China
关键词:
缺氧; 瘦素; 呼吸
Keywords:
hypoxia;  leptin;  respiration
分类号:
R341; R364.4; R446.1
文献标志码:
A
摘要:
目的    观察缺氧后小鼠血清和中枢神经系统瘦素水平的变化。    方法    以C57BL/6J小鼠为研究对象，利用医学自动测控缺氧仓(XQ-I型)复制机体常压缺氧状态，分为正常组、缺氧24 h组、缺氧48 h组，收集小鼠血清、脑脊液和脑组织（去除大脑和小脑后）匀浆标本，利用放射免疫方法检测瘦素浓度。    结果    缺氧24、48 h组小鼠血清、脑脊液和脑组织内的瘦素水平均显著高于未缺氧小鼠(P<0.05)，但缺氧24 h组和缺氧48 h组之间没有明显差别(P>0.05)。     结论    缺氧可作为一种独立的诱导因素促进小鼠脂肪组织瘦素的表达，同时使进入中枢神经系统内的瘦素水平亦明显增加。
Abstract:
Objective    To investigate the influence of hypoxia on leptin expression in serum, CSF and brain tissue of C57BL/6J mice.     Methods    C57BL/6J mice were divided into 3 groups: the normal control, 24-hour hypoxia group and 48-hour hypoxia group. The latter two groups exposed to hypoxia in the man-made auto pressure and hypoxia control cabin (XQ-I). Radioimmunoassay was used to detect the leptin level.     Results    The leptin level in the serum, CSF and brain tissue of mice exposed to hypoxia were higher than that of normal control, but no difference was found between 24-hour hypoxia group and 48-hour hypoxia group.     Conclusion    Hypoxia probably induces the increasing of leptin expression in fat tissue, as well as in the central nervous system.

参考文献/References:

刘茜, 吴亚梅, 徐玲, 等. 急性缺氧诱导C57BL/6J小鼠瘦素表达增加[J]. 第三军医大学学报, 2007, 29(13):1311-1312.

相似文献/References:

[1]刘波,吴小翎,张霞,等.福辛普利对非酒精性脂肪性肝炎大鼠肝纤维化的作用[J].第三军医大学学报,2012,34(16):1646.
　Liu Bo,Wu Xiaoling,Zhang Xia,et al.Effects and mechanism of fosinopril on hepatic fibrosis in rats with nonalcoholic steatohepatitis[J].J Third Mil Med Univ,2012,34(13):1646.
[2]吴艳,王毅,曾绍凡,等.老年2型糖尿病瘦素、骨密度变化及相关因素的研究[J].第三军医大学学报,2007,29(22):2188.
　WU Yan,WANG Yi,ZENG Shao-fan,et al.Bone density, leptin level and other related factors in elder patients with type 2 diabetes[J].J Third Mil Med Univ,2007,29(13):2188.
[3]周帅,蒋理,程崇杰,等.载脂蛋白E对星形胶质细胞缺氧性损伤的保护作用[J].第三军医大学学报,2012,34(20):2067.
　Zhou Shuai,Jiang Li,Cheng Chongjie,et al.Apolipoprotein E protects hypoxic injuried astrocytes in vitro[J].J Third Mil Med Univ,2012,34(13):2067.
[4]生宝亮,徐刚,陈德伟,等.大鼠实验性高原肺水肿中T-AOC、MDA、SOD、CAT和IL-6的表达[J].第三军医大学学报,2012,34(23):2364.
　Sheng Baoliang,Xu Gang,Chen Dewei,et al.T-AOC，MDA，SOD，CAT and IL-6 levels in rat pulmonary edema induced by hypobaric hypoxia[J].J Third Mil Med Univ,2012,34(13):2364.
[5]邹哲华,陶陶,徐坚,等.大鼠大脑皮层神经元缺氧后细胞凋亡情况的动态观察[J].第三军医大学学报,2012,34(24):2489.
　Zou Zhehua,Tao Tao,Xu Jian,et al.Dynamic changes of apoptosis in rat cerebral cortex neurons after hypoxia[J].J Third Mil Med Univ,2012,34(13):2489.
[6]魏勇,顾健腾,鲁开智,等.瑞芬太尼对肝细胞缺氧复氧损伤保护作用的机制研究[J].第三军医大学学报,2007,29(20):1976.
　WEI Yong,GU Jian-teng,LU Kai-zhi,et al.Remifentanyl protects hepatocytes against anoxia-reoxygenation injury[J].J Third Mil Med Univ,2007,29(13):1976.
[7]杨兆瑞,吴晴,陈嘉薇,等.HIF-1α、JNK1、P-gp、MRP1和LRP蛋白在胃癌中的表达与临床病理及预后的关系[J].第三军医大学学报,2007,29(18):1755.
　YANG Zhao-rui,WU Qing,CHEN Jia-wei,et al.Expressions, clinicopathological features and prognostic significance of HIF-1α, JNK1, P-gp, MRP1 and LRP proteins in human gastric carcinoma[J].J Third Mil Med Univ,2007,29(13):1755.
[8]罗红,高文祥,高钰琪,等.茶多酚预防缺氧大鼠红细胞增多症的实验研究[J].第三军医大学学报,2007,29(14):1381.
　LUO Hong,GAO Wen-xiang,GAO Yu-qi,et al.Protective effects of tea polyphenols on polycythemia induced by chronic hypoxia in rats[J].J Third Mil Med Univ,2007,29(13):1381.
[9]张钢,高钰琪,刘福玉.缺氧对大鼠白细胞粘弹性的影响[J].第三军医大学学报,2008,30(01):46.
　ZHANG Gang,GAO Yu-qi,LIU Fu-yu.Effects of hypoxia on viscoelastic properties of polymorphonuclear leukocyte of rats[J].J Third Mil Med Univ,2008,30(13):46.
[10]陈建,黄缄,高钰琪,等.预缺氧对大鼠低压缺氧性脑损伤保护作用的实验研究[J].第三军医大学学报,2007,29(22):2113.
　CHEN Jian,HUANG Jian,GAO Yu-qi,et al.Protective effects of hypoxia preconditioning on rat brain against hypobaric hypoxia[J].J Third Mil Med Univ,2007,29(13):2113.

更新日期/Last Update: 2008-10-15