[1]李颖,何威,何云志,等.脂溢性角化病皮损区Smurf1和Smurf2表达增强[J].陆军军医大学学报(原第三军医大学学报),2007,29(10):911-914.
 LI Ying,HE Wei,HE Yun-zhi,et al.Increased expression of Smurf1 and Smurf2 in seborrheic keratosis[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(10):911-914.
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第10期
页码:
911-914
栏目:
论著
出版日期:
2007-05-30

文章信息/Info

Title:
Increased expression of Smurf1 and Smurf2 in seborrheic keratosis
作者:
李颖何威 何云志黄海王亚丽杨扬
第三军医大学新桥医院:皮肤科,病理科
Author(s):
LI Ying HE Wei HE Yun-zhi HUANG Hai WANG Ya-li YANG Yang
Department of Dermatology, Department of Pathology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
关键词:
脂溢性角化病Smurf1Smurf2转化生长因子β信号通路
Keywords:
seborrheic keratosis Smurf1 Smurf2 TGF-β signal transduction pathway
分类号:
R322.99; R392.3; R758.730.2
文献标志码:
A
摘要:
目的    探讨脂溢性角化病皮损区Smad泛素化调节因子1和2(Smad ubiquitination regulatory factor 1 and 2, Smurf1, 2)的表达及其意义。    方法    采用实时定量聚合酶链式反应(quantitative Real-time PCR,RT-PCR)和免疫组织化学技术分别检测脂溢性角化病皮损和对照正常皮肤中Smurf1和2的表达情况。    结果    与对照正常皮肤相比,脂溢性角化病皮损中Smurf1和2表达水平上调。    结论    脂溢性角化病皮损中Smurf1和2的过度表达可干扰转化生长因子β(transforming growth factor-β, TGF-β)信号转导通路,可能使TGF-β抑制上皮增生的作用不能有效发挥,促进了脂溢性角化病表皮的过度增生。
Abstract:
Objective    To investigate the expression of Smad ubiquitination regulatory factor 1 and 2 (Smurf1, Smurf2) in the seborrheic keratosis.     Methods    Quantitative Real-Time PCR and immunohistochemical techniques were used to assess the expression of Smurf1 and Smurf2 in seborrheic keratosis and normal control skin.     Results    The expression levels of Smurf1 and Smurf2 in the epidermis of seborrheic keratosis that affected 65 cases (27 male and 38 female, average age: 58.5 years, average course of disease: 4.1 years) admitted to our hospital, were markedly increased in comparison with those of normal control skins from the 30 subjects (10 male and 20 female, average age: 47 years) who underwent plastic surgery.     Conclusion    Overexpressions of Smurf1 and Smurf2 interfere in TGF-β signaling and contribute to formation of aberrant hyperplastic epidermis in seborrheic keratosis.

相似文献/References:

[1]杨扬,何威,李颖,等.脂溢性角化病皮损区受体活化Smad的变化[J].陆军军医大学学报(原第三军医大学学报),2007,29(23):2219.
 YANG Yang,HE Wei,LI Ying,et al.Down-regulation of receptor-activited Smads in seborrheic keratosis[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(10):2219.
[2]李颖,何威,林自华,等.脂溢性角化病皮损的表皮中TGF-βⅠ型和Ⅱ型受体表达下调[J].陆军军医大学学报(原第三军医大学学报),2006,28(03):239.

更新日期/Last Update: 2008-10-24