[1]鄢仁晴,罗军敏,孙万邦,等.肺结核患者外周血树突状细胞亚群的变化[J].第三军医大学学报,2007,29(13):1298-1300.
 YAN Ren-qing,LUO Jun-min,SUN Wan-bang,et al.Changes of peripheral blood dendritic cell subgroup in pulmonary tuberculosis patients[J].J Third Mil Med Univ,2007,29(13):1298-1300.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第13期
页码:
1298-1300
栏目:
论著
出版日期:
2007-07-15

文章信息/Info

Title:
Changes of peripheral blood dendritic cell subgroup in pulmonary tuberculosis patients
作者:
鄢仁晴罗军敏孙万邦祁莹
遵义医学院:附属医院检验科,免疫学教研室,附属医院细胞工程室
Author(s):
YAN Ren-qing LUO Jun-min SUN Wan-bang QI Ying
Clinlic Medical Laboratory, Cell Engineering Laboratory, The First Affiliated Hospital, Department of Immunology, Zunyi Medical College, Zunyi 563003, China
关键词:
肺结核树突细胞亚群流式细胞术
Keywords:
pulmonary tuberculosis dendritic cell subgroup flow cytometry
分类号:
R392.12; R392.3; R521.02
文献标志码:
A
摘要:
目的    通过对肺结核患者外周血树突细胞(dendritic cell,DC)亚群数量的观察,了解DC亚群在肺结核病程中的变化情况,探讨DC亚群在肺结核发病机制中的作用及临床意义。    方法    采用流式细胞术的三色分析法检测70例肺结核患者外周血的DC1及DC2亚群。      结果    肺结核活动期患者外周血DC1/PBMC(外周血单个核细胞)、DC2/PBMC及DC1、DC2的绝对数均明显低于健康者(P<0.05),DC1/DC2值明显高于健康者(P<0.05);肺结核非活动期患者与健康者外周血DC1/PBMC、DC2/PBMC及DC1、DC2的绝对数比较均无显著性差异(P>0.05),与健康者比较DC1/DC2值无显著性差异(P>0.05);肺结核活动期患者外周血DC的绝对数明显低于非活动期(P<0.05)。      结论    肺结核患者外周血DC1和DC2数均明显降低。提示外周血树突细胞亚群(DC1、DC2)的检测可了解肺结核患者的免疫功能状态及反映病情变化,也说明DC在结核病免疫损伤的发生发展中发挥一定作用。
Abstract:
Objective    To observe the changes of peripheral blood dendritic cell (DC) subgroup in amount in pulmonary tuberculosis patients.     Methods    DC1 and DC2 subgroups were detected in peripheral blood of 70 pulmonary tuberculosis patients by tricolor analytic method of flow cytometry.     Results    In active stage of pulmonary tuberculosis, DC1/PBMC, DC2/PBMC and the absolute quantity of DC1, DC2 in peripheral blood were significantly lower than healthy subjects (P<0.05) and DC1/DC2 ratio was significantly higher (P<0.05). In inactive stage of pulmonary tuberculosis, DC1/PBMC, DC2/PBMC and the absolute quantity of DC1, DC2, DC1/DC2 ratio in peripheral blood showed no significant difference with that of healthy subjects (P>0.05); The absolute quantity of DC2 in active stage of pulmonary tuberculosis was obviously lower than that in inactive stage (P<0.05).      Conclusion    The percentage and the absolute quantity of DC1 and DC2 subgroups in peripheral blood in active stage of pulmonary tuberculosis are lower than the healthy subjects, suggesting DC can reflect the immune function of pulmonary tuberculosis patients, the patients’ condition and illuminate the immunopathogenesis of pulmonary tuberculosis.

参考文献/References:

鄢仁晴, 罗军敏, 孙万邦, 等. 肺结核患者外周血树突状细胞亚群的变化[J]. 第三军医大学学报, 2007, 29(13):1298-1300.

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更新日期/Last Update: 2008-10-15