[1]陈玮,赵涌.MCM5和Ki67在宫颈上皮内瘤变及宫颈癌组织中表达及意义[J].陆军军医大学学报(原第三军医大学学报),2007,29(14):1436-1439.
　CHEN Wei,ZHAO Yong.Expressions of MCM5 and Ki67 in cervical intraepithelial neoplasia and cervical cancer and their clinical significance[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(14):1436-1439.
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第14期
页码:
1436-1439
栏目:
论著
出版日期:
2007-07-30

文章信息/Info

Title:
Expressions of MCM5 and Ki67 in cervical intraepithelial neoplasia and cervical cancer and their clinical significance
作者:
陈玮; 赵涌
重庆医科大学基础医学院病理学教研室
Author(s):
CHEN Wei;  ZHAO Yong
Department of Pathology, Institute of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China
关键词:
MCM5; Ki67; 宫颈癌; CIN; 免疫组织化学
Keywords:
MCM5;  Ki67;  cervical cancer;  cervical intraepithelial neoplasia;  immunohistochemistry
分类号:
R730.21；R730.43；R737.3
文献标志码:
A
摘要:
目的    探讨微小染色体维持蛋白-5（minichromosome maintenance-5, MCM5）和Ki67在宫颈上皮内瘤变（cervical intraepithelial neoplasia, CIN)及宫颈癌组织中的表达及临床病理意义。    方法    采用免疫组化技术(S-P法)检测MCM5和Ki67在99 例宫颈CIN和宫颈癌中的表达。    结果    MCM5和Ki67在正常宫颈黏膜上皮、CINⅠ～Ⅱ级、CIN Ⅲ级、浸润癌表达的阳性率分别为26.7%、72.0%、80.0%、97.9%和10.0%、32.4%、84.0%、97.9%。各级CIN与浸润癌相比MCM5的表达率差异具有显著性(P<0.05)；在CIN Ⅲ级和宫颈癌中 MCM5的表达与Ki67表达呈正相关(r=0.687,0.936, P<0.05)。MCM5和Ki67表达率与临床分期及病理分级有关(P<0.05) 。    结论    MCM5和Ki67可作为反映宫颈上皮增生病变程度及生物学行为的指标，对宫颈非浸润性病变与浸润性病变的诊断及鉴别有参考价值。
Abstract:
Objective    To study the expressions of MCM5 and Ki67 in cervical intraepithelial neoplasia (CIN) and cervical cancer and their clinical significance.      Methods    Immunohistochemistry (S-P method) was used to detect the expressions of MCM5 and Ki67 in 50 CIN and 49 cervical cancer.      Results    The positive expression rate of MCM5 and Ki67 in normal cervical epithelium, CIN Ⅰ-Ⅱ, CIN Ⅲ and cervical cancer were 26.7%, 72.0%, 80.0%, 97.9% and 10.0%, 32.4%, 84.0%, 97.9% respectively. The positive expression rate of MCM5 was significantly different between CIN and cervical cancer (P<0.05). The expressions of MCM5 and Ki67 had a positive correlation in CIN Ⅲ and cervical cancer (P<0.05). The positive expressions of MCM5 and Ki67 were closely correlated with clinical stage and pathological grade of cervical cancer (P<0.05).     Conclusion    MCM5 and Ki67 may be used as markers for aggressive biological behavior in cervical cancer, and may be useful to distinguish CIN and cervical cancer.

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更新日期/Last Update: 2008-10-07