[1]李大奇,况利,王敏建.不同电休克方法对抑郁模型大鼠海马干扰素-γ受体表达的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(15):1494-1496.
　LI Da-qi,KUANG Li,WANG Min-jian.Effects of electroshock on interferon gamma receptor expression in hippocampus of depressed rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(15):1494-1496.
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不同电休克方法对抑郁模型大鼠海马干扰素-γ受体表达的影响(/HTML )
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第15期
页码:
1494-1496
栏目:
论著
出版日期:
2007-08-15

文章信息/Info

Title:
Effects of electroshock on interferon gamma receptor expression in hippocampus of depressed rats
作者:
李大奇; 况利; 王敏建
重庆医科大学附属第一医院心理卫生中心
Author(s):
LI Da-qi;  KUANG Li;  WANG Min-jian
Center of Mental Health,The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China
关键词:
抑郁症; 海马; 电休克; 干扰素-γ
Keywords:
depression;  hippocampus;  electroshock;  interferon gamma
分类号:
R454.1; R714.02; R749.4
文献标志码:
A
摘要:
目的    观察干扰素-γ受体（IFN-γR）在抑郁模型大鼠海马神经元及胶质细胞中的再生。            方法    采用慢性轻度不可预见性的应激(chronic unpredicped mild stress, CUMS)和孤养建立大鼠抑郁模型，开场分析（open-field test）进行行为学观察。对模型大鼠行电休克（electro-convulsive treatment, ECT）及丙泊酚无抽搐电休克（modified electric convulsive therapy, MECT）疗法,免疫荧光及原位杂交方法观察海马结构中神经元和胶质细胞上IFN-γR的表达情况。     结果    应激+ECT组、应激+MECT组与应激+假电击组比较，开场分析、免疫荧光及原位杂交实验均有显著差异。     结论    MECT治疗和ECT治疗均能减少抑郁模型大鼠海马神经元及胶质细胞上IFN-γR的表达，细胞因子（cytokine, CK）可能参与抑郁症的病理机制，MECT治疗疗效可能较ECT治疗为优。
Abstract:
Objective    To observe the expression of interferon gamma receptor on neuron and astrocyte of the hippocampus of depressed rats.      Methods    The depressed rats were produced by separation raise and unpredictable mild stressors.Their behaviors were evaluated in open-field test. The rats underwent electro-convulsive treatment (ECT) or modified electric convulsive therapy (MECT). The expression of interferon gamma receptor on neuron and astrocyte of the hippocampus was detected by immunofluorescence and in situ hybridization.      Results    There were significant differences among the stress plus ECT group,the stress plus MECT group, the stress plus sham electroshock group in all the three tests.      Conclusion    ECT and MECT can both reduce the expression of interferon gamma receptor on neuron and astrocyte of the hippocampus of depressed rats, and MECT shows more stronger therapeutic effect. Cytokine may play an important role in the pathophysiologic mechanism of depression.

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更新日期/Last Update: 2008-09-26