[1]李大奇,况利,王敏建.不同电休克方法对抑郁模型大鼠海马干扰素-γ受体表达的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(15):1494-1496.
　LI Da-qi,KUANG Li,WANG Min-jian.Effects of electroshock on interferon gamma receptor expression in hippocampus of depressed rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(15):1494-1496.
点击复制

不同电休克方法对抑郁模型大鼠海马干扰素-γ受体表达的影响(/HTML )
分享到：

陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第15期
页码:
1494-1496
栏目:
论著
出版日期:
2007-08-15

文章信息/Info

Title:
Effects of electroshock on interferon gamma receptor expression in hippocampus of depressed rats
作者:
李大奇; 况利; 王敏建
重庆医科大学附属第一医院心理卫生中心
Author(s):
LI Da-qi;  KUANG Li;  WANG Min-jian
Center of Mental Health,The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China
关键词:
抑郁症; 海马; 电休克; 干扰素-γ
Keywords:
depression;  hippocampus;  electroshock;  interferon gamma
分类号:
R454.1; R714.02; R749.4
文献标志码:
A
摘要:
目的    观察干扰素-γ受体（IFN-γR）在抑郁模型大鼠海马神经元及胶质细胞中的再生。            方法    采用慢性轻度不可预见性的应激(chronic unpredicped mild stress, CUMS)和孤养建立大鼠抑郁模型，开场分析（open-field test）进行行为学观察。对模型大鼠行电休克（electro-convulsive treatment, ECT）及丙泊酚无抽搐电休克（modified electric convulsive therapy, MECT）疗法,免疫荧光及原位杂交方法观察海马结构中神经元和胶质细胞上IFN-γR的表达情况。     结果    应激+ECT组、应激+MECT组与应激+假电击组比较，开场分析、免疫荧光及原位杂交实验均有显著差异。     结论    MECT治疗和ECT治疗均能减少抑郁模型大鼠海马神经元及胶质细胞上IFN-γR的表达，细胞因子（cytokine, CK）可能参与抑郁症的病理机制，MECT治疗疗效可能较ECT治疗为优。
Abstract:
Objective    To observe the expression of interferon gamma receptor on neuron and astrocyte of the hippocampus of depressed rats.      Methods    The depressed rats were produced by separation raise and unpredictable mild stressors.Their behaviors were evaluated in open-field test. The rats underwent electro-convulsive treatment (ECT) or modified electric convulsive therapy (MECT). The expression of interferon gamma receptor on neuron and astrocyte of the hippocampus was detected by immunofluorescence and in situ hybridization.      Results    There were significant differences among the stress plus ECT group,the stress plus MECT group, the stress plus sham electroshock group in all the three tests.      Conclusion    ECT and MECT can both reduce the expression of interferon gamma receptor on neuron and astrocyte of the hippocampus of depressed rats, and MECT shows more stronger therapeutic effect. Cytokine may play an important role in the pathophysiologic mechanism of depression.

相似文献/References:

[1]罗维,瞿广素.护理心理干预对慢性心力衰竭合并抑郁症患者心功能及生活质量的影响[J].陆军军医大学学报(原第三军医大学学报),2012,34(18):1918.
[2]耿淼,蒋宁,周文霞,等.当归芍药散对快速老化模型小鼠海马蛋白表达的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(06):477.
　GENG Miao,JIANG Ning,ZHOU Wen-xia,et al.Effect of powder of Chinese Angelica and Peony on expressions of hippocampal proteins in senescence accelerated mice[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(15):477.
[3]陈建,黄缄,高钰琪,等.预缺氧对大鼠低压缺氧性脑损伤保护作用的实验研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(22):2113.
　CHEN Jian,HUANG Jian,GAO Yu-qi,et al.Protective effects of hypoxia preconditioning on rat brain against hypobaric hypoxia[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(15):2113.
[4]吴喜贵,赵延东,阮怀珍.缺氧对大鼠皮层、海马NMDA受体NR1亚单位磷酸化的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(18):1742.
　WU Xi-gui,ZHAO Yan-dong,RUAN Huai-zhen.Effect of hypoxia on NR1 subunit of NMDA receptor in rat cortex and hippocampus[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(15):1742.
[5]耿明英,程远,许民辉,等.伽玛刀对红藻氨酸模型大鼠海马形态学及苔藓纤维变化的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(10):959.
　GENG Ming-ying,CHENG Yuan,XU Min-hui,et al.Effects of gamma knife on morphological changes of hippocampal formation and mossy fiber sprouting in epileptic rats induced by kainic acid[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(15):959.
[6]赵延东,程赛宇,张金海,等.低压缺氧对大鼠海马CA1区神经元P2X受体表达的影响[J].陆军军医大学学报(原第三军医大学学报),2006,28(23):2302.
[7]鲁利群,赵聪敏,蒲昭霞.生长相关蛋白在缺氧缺血性脑损伤新生大鼠海马中的表达变化[J].陆军军医大学学报(原第三军医大学学报),2006,28(21):2160.
[8]张映琦,廖维宏,迟路湘,等.癫痫状态大鼠海马GABA、GABAA受体α5亚单位表达的动态变化[J].陆军军医大学学报(原第三军医大学学报),2006,28(20):2047.
[9]周红梅,孔祥英,何念海,等.高压氧对缺血缺氧性脑损伤幼鼠海马超微结构及主动回避反应的影响[J].陆军军医大学学报(原第三军医大学学报),2006,28(19):1973.
[10]胡越,蒋莉,张晓萍.持续惊厥后海马神经营养因子表达及其影响因素[J].陆军军医大学学报(原第三军医大学学报),2006,28(16):1663.
[11]牟君,谢鹏.海马神经发生障碍——抑郁症发病机制的新观念[J].陆军军医大学学报(原第三军医大学学报),2006,28(11):1264.
[12]黎雪梅,况利.抗抑郁药物促进抑郁模型大鼠行为和海马血管内皮细胞生长因子的表达[J].陆军军医大学学报(原第三军医大学学报),2009,31(05):430.
　LI Xue-mei,KUANG Li.Effect of antidepressant on behavior and vascular endothelial cell growth factor in hippocampus of rat model of depression[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(15):430.
[13]肖凯,罗艳敏,梁芯,等.抑郁症模型大鼠海马内小胶质细胞数量和炎症因子表达增加[J].陆军军医大学学报(原第三军医大学学报),2021,43(05):367.
　XIAO Kai,LUO Yanmin,LIANG Xin,et al.Increased number of microglia and enhanced expression of inflammatory factors in the hippocampus of rat model of depression[J].J Amry Med Univ (J Third Mil Med Univ),2021,43(15):367.

更新日期/Last Update: 2008-09-26