[1]朱渝军,黄显凯.严重多发伤患者血浆血栓调节蛋白水平的变化及与弥散性血管内凝血的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(07):620-622.
 ZHU Yu-jun,HUANG Xian-kai.Changes of plasma thrombomodulin levels in multiple-injury patients and their relation with disseminated intravascular coagulation[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(07):620-622.
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严重多发伤患者血浆血栓调节蛋白水平的变化及与弥散性血管内凝血的关系(/HTML )
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第07期
页码:
620-622
栏目:
论著
出版日期:
2007-04-15

文章信息/Info

Title:
Changes of plasma thrombomodulin levels in multiple-injury patients and their relation with disseminated intravascular coagulation
作者:
朱渝军黄显凯
第三军医大学大坪医院野战外科研究所全军战创伤中心
Author(s):
ZHU Yu-jun HUANG Xian-kai
Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China
关键词:
多发伤弥散性血管内凝血血栓调节蛋白
Keywords:
multiple-injury disseminated intravascular coagulation thrombomodulin
分类号:
R446.11; R554.802; R641.06
文献标志码:
A
摘要:
目的     探讨严重多发伤患者血浆血栓调节蛋白(thrombomodulin, TM)水平变化及与创伤后弥散性血管内凝血(disseminated intravascular coagulation, DIC)之间的关系。     方法     将66例多发伤患者分为轻伤组(ISS评分<16分)21例和重伤组(ISS评分≥16分)45例,再把重伤患者分为并发DIC组(12例)与未并发DIC组(33例)。另10例健康人为正常对照组。正常对照组采外周静脉血1次,其余组分别于伤后1、3、7 d空腹采集外周静脉血,应用ELISA方法测定血浆TM浓度。     结果     轻伤与重伤组血浆TM水平伤后均明显高于正常对照组,且重伤组又明显高于轻伤组。非DIC组伤后TM水平迅速降低,DIC组TM水平先升高后降低,DIC组的TM水平显著高于非DIC组。     结论     创伤后急性期TM水平的升高程度不仅与创伤严重程度有关,而且与创伤后DIC的发生显著正相关。因此,测定严重多发伤患者急性期外周血浆TM水平变化对预测创伤后DIC的发生具有一定价值。
Abstract:
Objective     To explore the relation between traumatic disseminated intravascular coagulation (DIC) and the level of plasma thrombomodulin (TM) in severe multiple-injury patients.      Methods     Sixty-six multiple-injury patients were divided into minor-injury group (ISS<16, 21cases) and severe injury group (ISS≥16, 45 cases).Then the severe multiple-injury group was subdivided into DIC group (12 cases) and non-DIC group (33 cases). The other 10 healthy people served as the control group. Venous blood was collected once in the control group and in other groups venous blood was collected on day 1, 3 and 7 after trauma. The TM concentration was determined by ELISA.      Results     The TM levels of the minor-injury and severe injury groups were higher than those of the control group, and the severe injury group was remarkably higher than the minor-injury group. In the non-DIC group, the TM level continuously declined; while in the DIC group, it rose at first and then decreased remarkably, with the level being remarkably higher in DIC group than  non-DIC one.      Conclusion     TM level is not only relevant to the severity of trauma, but also closely relevant to the occurrence of traumatic DIC after trauma. The detection of plasma TM level can predict the occurrence of DIC.

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更新日期/Last Update: 2008-10-28