[1]伍俊,周娟,袁祖贻,等.hsCRP水平正常者血清Hcy浓度与冠状动脉病变的关系[J].第三军医大学学报,2019,41(21):2132-2136.
 WU Jun,ZHOU Juan,et al.Correlation of serum Hcy level with coronary artery disease in patients with normal hsCRP[J].J Third Mil Med Univ,2019,41(21):2132-2136.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
41卷
期数:
2019年第21期
页码:
2132-2136
栏目:
临床医学
出版日期:
2019-11-15

文章信息/Info

Title:
Correlation of serum Hcy level with coronary artery disease in patients with normal hsCRP
作者:
伍俊12周娟13袁祖贻134郜珊珊1王丽君13
710061 西安,西安交通大学第一附属医院心内科1;710075 西安,西安高新医院神经内科2;710061 西安,陕西省分子心脏病学重点实验室3;710061 西安,环境与疾病相关教育部重点实验室4
Author(s):
WU Jun1 2 ZHOU Juan1 3 YUAN Zuyi1 3 4 GAO Shanshan1 WANG Lijun13  

1Department of Cardiology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, 710061; 2Department of Neurology, Xi’an Gaoxin Hospital, Xi’an, Shaanxi Province, 710075; 3Key Laboratory of Molecular Cardiology, Xi’an, Shaanxi Province, 710061; 4Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Xi’an Jiaotong University, Xi’an, Shaanxi Province, 710061, China

关键词:
冠状动脉造影冠状动脉狭窄超敏C反应蛋白同型半胱氨酸
Keywords:
coronary angiography coronary stenosis high-sensitivity C-reactive protein homocysteine
分类号:
R182.32;R446.112;R543.302
文献标志码:
A
摘要:

目的观察和分析超敏C反应蛋白(high sensitive C-reactive protein,hsCRP)水平正常者血清Hcy浓度与冠状动脉病变(coronary artery disease,CAD)的关系。方法 纳入2017年4月至2019年4月期间在西安交通大学第一附属医院心内科接受冠状动脉造影且hsCRP≤2.0 mg/L的患者共4 097例,其中男性2 787例,女性1 310例。按照血清Hcy三分位数水平将所有入选者分为高(>19.40 μmol/L)、中(>13.90~19.40 μmol/L)、低(≤13.90 μmol/L)3组,比较各组入选病例基线和临床生化指标的差异,Logistic回归分析评估Hcy浓度与CAD患病率及严重程度的关系。结果高Hcy组的CAD严重程度较低Hcy组更重(Gensini评分35.39±33.95 vs 26.25±27.04,P<0.001),且血清Hcy浓度与Gensini评分显著正相关(r=0.122,P<0.001);高Hcy组的急性心肌梗死(15.2% vs 9.2%,P<0.001)和三支病变比例(34.8% vs 29.0%,P=0.004)显著高于低Hcy组;Logistic回归分析显示在校正所有基线差异后,血清Hcy浓度仍然与CAD的患病率(P=0.006)、急性心肌梗死(P=0.001)和更严重的CAD(P=0.002)显著正相关。结论在hsCRP水平正常者中,血清Hcy浓度是CAD患病率和严重程度的独立预测因子。

Abstract:

ObjectiveTo observe and analyze the relationship between serum Hcy concentration and coronary artery disease (CAD) in patients with normal high-sensitivity C-reactive protein (hsCRP) level. MethodsA total of 4 097 patients (2 787 males and 1 310 females) who underwent coronary angiography and had hsCRP ≤2.0 mg/L in the Department of Cardiology, First Affiliated Hospital of Xi’an Jiaotong University from April 2017 to April 2019 were enrolled in this study. According to serum Hcy level in the tertile, they were divided into high, middle and low level groups (>19.40, >13.90~19.40, ≤13.90 μmol/L). The differences in baseline data and clinical biochemical parameters were compared among the groups. Logistic regression analysis was used to evaluate the relationship between Hcy concentration with CAD prevalence and severity. ResultsThe severity of CAD was more serious in the high Hcy group than the low Hcy group (Gensini score: 35.39±33.95 vs 26.25±27.04, P<0.001), and the serum Hcy level was significantly positively correlated with the Gensini score (r=0.122, P<0.001). The incidence rates of acute myocardial infarction (15.2% vs 9.2%, P<0.001) and three-vessel disease (34.8% vs 29.0%, P=0.004) were significantly higher in the high Hcy group than low Hcy group. Logistic regression analysis showed that after adjustment for all baseline differences, serum Hcy level was still positively correlated with the prevalence (P=0.006) and severity (P=0.002) of CAD and the incidence of acute myocardial infarction (P=0.001). ConclusionSerum Hcy may be an independent predictor of CAD prevalence and severity in patients with normal hsCRP level.

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更新日期/Last Update: 2019-11-12