[1]王铖,索朗德吉,扎西次仁,等.西藏日喀则藏族456例9项单基因遗传性状分析[J].第三军医大学学报,2018,40(18):1693-1698.
 WANG Cheng,Suolangdeji,Zhaxiciren,et al.Analysis of 9 single gene traits in Tibetan population in Shigatse[J].J Third Mil Med Univ,2018,40(18):1693-1698.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
40卷
期数:
2018年第18期
页码:
1693-1698
栏目:
临床医学
出版日期:
2018-09-30

文章信息/Info

Title:
Analysis of 9 single gene traits in Tibetan population in Shigatse
作者:
王铖索朗德吉扎西次仁旦增曲扎向虹霞巴桑卓玛
西藏大学医学院:15级护理本科班,高原医学研究中心
Author(s):
WANG Cheng Suolangdeji Zhaxiciren Danzengquzha XIANG Hongxia Basangzhuoma

Grade 15 Nursing Class, 2Plateau Medical Research Center, Tibet University Medical College, Lhasa, Tibet Autonomous Region, 850000, China

关键词:
单基因遗传遗传性状藏族遗传相关性
Keywords:
single gene traits genetic characteristics Tibet correlation analysis
分类号:
R195.1;R394.5
文献标志码:
A
摘要:

目的    调查西藏日喀则藏族9项人类单基因遗传性状的分布特征,探讨遗传性状与民族之间的相关性。方法    2017年8月收集在西藏某大学籍贯为日喀则的藏族大学生456例,其中男性220例,女性236例。调查其9项人类学指标(眼睑、耳垂类型、拇指指型、酒窝、惯用手、卷舌、发旋、头发类型、发际),判别标准主要依据吴汝康等(1984)的《人体测量方法》和邵象清(1985)的《人体测量手册》。调查数据采用SPSS17.0统计软件进行处理。结果    在日喀则藏族群体中拇指指型、头发类型、发际类型的隐形基因频率高于显性基因频率,其余6对性状反之;不同性别眼睑、发际及头发类型分布差异有统计学意义(P<0.05);相关性分析结果显示,发旋与耳垂类型、拇指指型、发际存在相关性,头发类型与耳垂、发际与酒窝也存在相关性(P<0.05),而其他性状间无相关性;日喀则藏族与文献报道的西藏林芝藏族和我国其他民族各性状分布特征进行比较,发现存在不同程度的差异。结论    日喀则藏族群体9项单基因遗传性状分布具有其特异性,提示环境因素在性状的形成过程中有一定的影响。

Abstract:

Objective     To investigate the distribution characteristics of 9 single gene traits in Tibetan population in Shigatse (Tibet Autonomous Region, China) and explore the relations between the distribution of the genetic traits and nationalities. Methods     This survey was carried out among 456 Tibetan students (including 220 male and 236 female students) in a university in Tibet to investigate the distributions of 9 single gene traits (eyelids, earlobe type, thump type, dimples, handedness, tongue rolling, hair whorls, hair type, and hairline). The incidence of each pair of traits was calculated and compared between male and female genders; the distributions of these traits in these college students were also compared with those in Tibetan populations in other regions and in other ethnic groups in China. Results    For thump type, hair type and hairline type, the frequencies of the recessive genes were significantly higher than those of the dominant genes, and the distribution of these 3 traits differed significantly between genders; a reverse pattern of the recessive and dominant gene frequencies was noted for the other 6 pairs of traits (P<0.05).   Correlation analysis of 9 genetic traits revealed correlations of hair whorls with the types of earlobe, thumb finger and hairline; hair type was found to correlate with the types of earlobe, hairline and dimples (P<0.05); no significant correlation was found among the other traits. The distribution pattern of these 9 traits in this Tibetan population was different from that reported in other Tibetan groups and other ethics groups in China. Conclusion    Tibetan population in Shigatse have specific distribution pattern of the 9 single gene traits, indicating that environmental factors can contribute to the formation of the genetic characteristics.

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更新日期/Last Update: 2018-09-29